ACY1

ACY1

Chemical Structure of the Core Region of Lipopolysaccharides

Published in Helmut Brade, Steven M. Opal, Stefanie N. Vogel, David C. Morrison, Endotoxin in Health and Disease, 2020

Otto Holst

Sialylated LPS was also identified in H. ducreyi (109,161), and, in strain ITM 5535 (161), Neu5Ac was identified as the terminal residue α-(2→3)-linked to the trisaccharide (β-Gal-(1→4)-β-GlcNAc-(1→3)-Gal. This trisaccharide is also present in the cores of strains ITM 2665, ITM3147, and ACY1, and in all cases connected via a d,d-Hep residue to O-6 of β-Glc.

Serum concentrations of aminoacylase 1 in schizophrenia as a potential biomarker: a case-sibling-control study

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Journal Information

Published in Nordic Journal of Psychiatry, 2022

Diğdem Göverti, Rabia Nazik Yüksel, Hasan Kaya, Nihan Büyüklüoğlu, Çiğdem Yücel, Erol Göka

Aminoacylase 1 (ACY1; EC 3.5.1.14) is a homodimeric, cytosolic, zinc-metalloprotein, and endogenous mammalian enzyme that has a role in the catabolism of N-terminally acetylated proteins and amino acids by proteolytic degradation [5]. It hydrolyses N-acetylated derivates of methionine, glutamine, serine, alanine, glycine, leucine, and valine apart from N-acetyl-L-aspartate catalyzed by Aminoacylase 2 (EC 3.5.1.15) [6,7]. ACY1, also identified as a risk locus at schizophrenia and bipolar disorder, is encoded by chromosome 3p.21 and expressed by various tissue, particularly the brain and kidney [8,9]. Moreover, it regulates the function of the sphingosine kinase 1 enzyme defined with mitogenic and cytoprotective effects on cells [10].

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Chemical Structure of the Core Region of Lipopolysaccharides

Serum concentrations of aminoacylase 1 in schizophrenia as a potential biomarker: a case-sibling-control study