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Herbs in Cancer Therapy
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Annum Malik, Shahzadi Sidra Saleem, Kifayat Ullah Shah, Learn-Han Lee, Bey Hing Goh, Tahir Mehmood Khan
Viscum album L. has been used as an anti-cancerous agent, in adjuvant treatment since a very long time. It boosts up the immune system, that is, it increases both the quantity and the efficiency of neutrophils and natural killer cells. According to an investigation, the antineoplastic effects of lectin were observed by acquiring an extract from Viscum album C., which caused apoptosis-induced cellular death in tumor cell lines (Taraphdar et al. 2001).
Ethnobotanical Survey for Managing Selected Non-Communicable Diseases
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Godwin Ojochogu Adejo, Sunday Ene-Ojo Atawodi, Kingsley Okoyomoh
Viscum album alleviates the side effects of cancer therapy. It has been used to treat hypertension, epilepsy, exhaustion, anxiety, arthritis, vertigo, and degenerative inflammation of the joints.110 The herb is known to relieve headaches due to high blood pressure. It also reduces heart rate and strengthens the capillary walls at the same time. The cardiotonic action is attributable to the presence of lignans while the hypotensive action is linked with its choline derivative related to acetylcholine, which exerts parasympathetic stimulation and vasodilation.173
Plant Lectins in Cancer Treatment: The Case of Viscum album L.
Published in Spyridon E. Kintzios, Maria G. Barberaki, Evangelia A. Flampouri, Plants That Fight Cancer, 2019
Plant lectins are bioactive molecules able to identify and recognize animal cell carbohydrates. Lectins exhibit significant properties for cancer diagnosis and treatment owing to their unique characteristic of distinguishing subtle alterations in cellular glycosylation. Several cellular responses are generated due to specific protein–cell bounding, resulting in a panel of activities ranging from immune system activation to cancer cell death. Lectin chemotherapy presented cytotoxic, apoptotic, autophagic, and antitumor effects, as well as significant immunostimulant and mitogenic properties. In addition to pharmaceutical practicing, plant lectins are also employed in histochemical techniques, towards malignant cells and tissues, aiming at the detection of glycoconjugates identified as cancer markers. The diagnostic potential of plant lectins has been particularly expanded by immobilizing them in microarrays, contributing to rapid and sensitive analysis of glycans. Viscum album L., the European mistletoe, is one of the most important plant species with anticancer properties, containing a number of anticancer compounds, in particular three cytotoxic and immunomodulatory lectins. In vitro and in vivo experiments provide significant indications that mistletoe-derived lectins exhibit anticancer activities, in a selective manner, against several cancer types. Nowadays, lectin-rich mistletoe preparations are at the top of anthroposophic cancer treatment and complementary therapy.
Radioprotective effect of mistletoe extract on intestinal toxicity: in vivo study using adult zebrafish
Published in International Journal of Radiation Biology, 2023
Sunmin Park, Suhyun Kim, Soonil Koun, Hae-Chul Park, Won Sup Yoon, Chai Hong Rim
Abnoba Viscum Q, a commercialized medicine composed of Viscum album (common mistletoe) extract, a parasite on the Quercus tree manufactured by Abnoba GmbH (Pforzheim, Germany), was donated by Abnoba Korea, a local sales agent company. Viscum album extract may contain different components, such as lectin or viscotoxin, depending on the host plant (‘Abnoba GmbH. Recommendations for use: Abnoba Viscum. Assessed July 1, 2018. Available at: http://www.anthromed.org/UploadedDocuments/Abnoba%20Viscum.pdf’). We used four types of extracts from different host plants (Abietis, Fraxini, Mali, and Quercus trees) in a previous study on zebrafish embryos and found the extracts from plant parasites on the Quercus tree to be the most effective (Rim, Koun, et al. 2019). Therefore, this experiment used Abnoba Viscum Q as a radioprotector candidate.
Radioprotective effects of mistletoe extract in zebrafish embryos in vivo
Published in International Journal of Radiation Biology, 2019
Chai Hong Rim, Soonil Koun, Hae-Chul Park, Suk Lee, Chul Yong Kim
Therefore, we aimed to study the radioprotective effect of Viscum album extract; V. album extract has known anti-cancer components including viscotoxin and lectin, and they exhibit anti-tumor effects by inducing apoptosis, inhibiting tumor growth (Urech et al. 2005), increasing immune activity (Yoon et al. 2003), and causing cell-cycle arrest (Siegle et al. 2001). Although a definitive conclusion that V. album extract may increase cancer curability is yet to be drawn (Lordick 2014), its beneficial effects on quality of life and evidence from studies that it can induce tumor remissions are promising (Kienle and Kiene 2007).