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Vinca rosea (Madagascar Periwinkle) and Adhatoda vesica (Malabar Nut)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Rajib Hossain, Md Shahazul Islam, Dipta Dey, Muhammad Torequl Islam
The medication is categorized as a mucolytic and expectorant drug by Charaka Samhita. The plant's active components, roots, leaves, and flowers, have a variety of pharmacological characteristics and are used to treat cough, chronic bronchitis, rheumatism, asthma, and bronchial asthma. The majority of medicinal plant species are high in biomolecules that can combat health risks, and many species of plants have lately been shown to have antibacterial activity. The leaves and roots contain several alkaloids (the most important of which is quinazoline alkaloid but also vasicine, vasicinone, vasicinolone, and vasicol), which may have bronchodilator properties. These alkaloids are believed to occur in conjunction with adhatoda acid. It has sedative, expectorant, antispasmodic, antihelmintic, bronchial antiseptic, and bronchodilator properties. For many years, leaf extract has been used to treat bronchitis and asthma. It helps with coughing and shortness of breath. It's also used to treat idiopathic thrombocytopenic purpura, local bleeding caused by peptic ulcer, piles, and menorrhagia. Its local use provides relief from pyorrhea and bleeding gums. Because the alkaloid content of the plant varies by genotype, vegetative propagation of the A. vasica plant is advised.
What We Learn from the History of Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
N.K.M. Ikbal, D. Induchoodan, D. Suresh Kumar
Thus, folk medicine, Western medicine and Ayurveda are three different approaches toward health and disease. For example, the tribal communities of India use the plant Adhatoda vasica in several ways to treat respiratory diseases. Flowers, root powder, decoctions of leaves or juice of leaves mixed with goat milk are administered for conditions like cough, cold, fever, bronchitis, malarial fever, asthma, tuberculosis and pneumonia (Arjariya and Chaurasia 2009; Desale et al. 2013). Adhatoda vasica is an important plant in Ayurveda, used in the treatment of coughs and other respiratory disorders. Formulations like Vāśāriṣṭam (Vaidyan and Pillai 1986), Vāśā ghṛtam, Vāśā khaṇḍa kūśmāṇḍakam, Vāśā khaṇḍam and Khaṇḍakādyō lauham are indicated in these conditions (Mishra 1983). Based on the information from Ayurveda, Amin and Mehta (1959) isolated for the first time vasicinone, a compound with bronchodilatory activity, in crystalline form from the leaves of Adhatoda vasica. One of the derivatives of vasicinone is bromhexine or bromhexine hydrochloride (N-cyclohexyl-N-methyl-(2-amino-3,5-dibromo-benzyl) amine hydrochloride). It was first introduced into the market in 1963 and has been used in the treatment of a variety of respiratory diseases (Zanasi et al. 2017). When used on the basis of different principles, the same medicinal plant is identified with different medical systems.
Identification of proper herbs
Published in C. P. Khare, Evidence-based Ayurveda, 2019
Vaasaa is equated with Adhatoda vasica Nees (Syns. A. zeylanica Medic., Justicia adhatoda Linn.). A. beddomei C. B. Clarke, used in Kerala, also contains vasicine and vasicinone. It is considered to be more active than A. zeylanica.
Reappraisal and perspectives of clinical drug–drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus
Published in Xenobiotica, 2018
Ranjeet Prasad Dash, R. Jayachandra Babu, Nuggehally R. Srinivas
Yet another aspect is the herb–drug interaction that has to be addressed for the AGIs. A recently published report enlists some chemical constituents such as vasicine, vasicinone, chebulanin, chebulagic acid, chebulinic acid, (−)-3-O-galloylepicatechin, (−)-3-O-galloylcatechin, 2,4,6-tribromophenol, 2,4-dibromophenol, cyanidin-3-galactoside, curcumin, demethoxycurcumin and bisdemethoxycurcumin, which are derived from plant sources and exhibiting AGI activity (Kumar et al., 2011). Thus, intake of these plants having these aforementioned compounds either as health supplements and/or complimentary therapy along with existing AGIs therapy may lead to potentiation of hypoglycaemic effect as well as may result in some adverse reactions.
In silico prediction of anticarcinogenic bioactivities of traditional anti-inflammatory plants used by tribal healers in Sathyamangalam wildlife Sanctuary, India
Published in Egyptian Journal of Basic and Applied Sciences, 2018
Pavithra Chinnasamy, Rajendran Arumugam
The maximum number of different cell line prediction were collected and tabulated with respective cancer type, probability, and type of cell. The compounds oleanolic acid and ursolic acid from Leucas aspera (Willd.) Link showed significant cytotoxity against stomach adenocarcinoma (0.820/MKN-74), thyroid carcinoma (0.592/8505C), upper aero digestive tract carcinoma (0.505/FaDu), pancreas adenocarcinoma (0.504/ASPC-1), and stomach carcinoma (0.502/MKN-7) with significant Pa values (Table 5). Likewise, sesamin of Sesamum indicum L. renders strong activity against lung carcinoma (0.760/A549), central nervous system oligodendroglioma (0.687/Hs683), central nervous system glioblastoma (0.522/SF-295), colon adenocarcinoma (0.506/HCC2998) and stomach adenocarcinoma (0.505/MKN-74) besides vasicinone from Sida acuta Burm.f. showed cytotoxicity against central nervous system oligodendroglioma (0.562/Hs683), Pleura mesothelioma (0.588/NCI-H2052) and lung carcinoma (0.530/PC-6). The other remaining compounds from the reported plants, Madhuca indica J.F.Gmel. (betulinic acid) (4), Lawsonia inermis L. (lawsaritol, Lawsone) (4), Abutilon indicum (L.) Sweet (Abruslactone A) (3), Lycopersicon esculentum Mill. (lycopene) (3), Polyalthia longifolia (Sonn.) Thwaites (liriodenine) (3), Chloroxylon swietenia DC (skimmianine, Swietenidin B) (2), Diospyros montana Roxb. (Diospyrin) (2), Gmelina arborea Roxb. (epieudesmin) (2) and Mallotus philippensis (Lam.) Müll.Arg. (friedelin) (2) showed cytotoxicity against various cell lines respective of their affecting tissue. Nyctanthes arbor-tristis L. (nyctanthic acid) inversely Butea monosperma (butin), Nelumbo nucifera Gaertn (Nuciferine) Tribulus terrestris L. (harmine) predicted with single cell lines cytotoxicity activity (Table 5).