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Infantile Atopic Dermatitis
Published in Donald Rudikoff, Steven R. Cohen, Noah Scheinfeld, Atopic Dermatitis and Eczematous Disorders, 2014
Sadaf H. Hussain, James R. Treat, Albert C. Yan
Eczema vaccinatum is a rare, life-threatening reaction occurring in patients with atopic dermatitis who are exposed to the smallpox vaccine virus. Although the prevalence of this condition has decreased since cessation of mandatory vaccinia immunizations, children of military personnel and others receiving the vaccine are still at risk because immunized individuals can shed live virus and inoculate contacts. As a result of the severity of the reaction, immunization of patients with atopic dermatitis or their close contacts is generally contraindicated unless smallpox represents an immediate risk. In the event of eczema vaccinatum, affected patients should be treated promptly with intramuscular vaccinia immune globulin (Centers for Disease Control and Prevention or CDC 2008).
Mpox: epidemiology, clinical manifestations and recent developments in treatment and prevention
Published in Expert Review of Anti-infective Therapy, 2023
Nikil Selvaraj, Shreya Shyam, Puvin Dhurairaj, Kaviarasan Thiruselvan, Akil Thiruselvan, Yochana Kancherla, Pritika Kandamaran
The FDA authorized Vaccinia immune globulin intravenous in 2005 for the treatment of side effects following immunization with the Vaccinia virus [20]. Prior to this, intramuscular (IM) injections of vaccine immune globulin were used. There have been thorough examinations and reports on how IM Vaccinia immune globulin has been used historically. In some published studies for human OPXV infections, the FDA-approved intravenous version of vaccinia
Monkeypox: another pandemic in the making?
Published in Baylor University Medical Center Proceedings, 2023
Prinay Sohal, Aakanksha Gupta, Shefali Gupta, Vasu Gupta, Ridhimaa Jain, Rohit Jain
Vaccinia immunoglobulin should be given for prophylaxis in individuals with severely impaired T-cell immunity, as the smallpox vaccine is contraindicated in them. Vaccinia immune globulin is the only medication licensed by the US Food and Drug Administration for the management of complications in the United States.39,44