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Order Tymovirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
The PVX particles are promising as a building block for hybrid organic–inorganic materials, as reviewed by Röder et al. (2019). Thus, the PVX particles were used to induce the deposition of silica, which could allow the development of new biomaterials with combined surface properties. The silica deposition on templates often involved the use of alkoxysilane precursors such as tetraethyl orthosilane, tetramethyl orthosilane, or (3-aminopropyl)triethoxysilane. The genetically modified PVX particles presenting the aa sequence YSDQPTQSSQRP fused to the N-terminus of the coat were able to promote mineralization with tetraethyl orthosilane at room temperature, allowing the development of hybrid materials with two or even three components designed using immunogold labeling (Van Rijn et al. 2015).
Nanomaterials for Theranostics: Recent Advances and Future Challenges *
Published in Valerio Voliani, Nanomaterials and Neoplasms, 2021
Eun-Kyung Lim, Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh, Kwangyeol Lee
Wong et al. synthesized silica nanotubes by an alumina membrane-templated sol–gel method and encapsulated both CdSe QDs and Fe3O4 nanoparticles for both magnetic guidance and optical tracking. Moreover, the resulting hydrophilic nanocomposites as potential drug delivery vehicles [859] were found to easily enter the interior of HeLa cells without cell damage. Lee et al. also adopted a similar strategy to form a hollow silica nanotube with a layer of Fe3O4 nanoparticles on the inner surface [860]. 5-FU, 4-nitrophenol, and ibuprofen were loaded as model drug molecules into the pores of magnetic nanotubes, functionalized with amino propyl triethoxysilane, to study the effect of the hydrogen-bonding interaction between the drug and the inner pore surfaces on drug release. It was observed that less than 10% of ibuprofen was released in 1 h, and 80% was released after 24 h. In the cases of 5-FU and 4-nitrophenol, however, more than 90% was released in 1 h.
Molecular Targets and Optical Probes
Published in George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos, Handbook of Small Animal Imaging, 2018
Eleni K. Efthimiadou, George Kordas
Surface coatings of IONPs not only provide colloidal suspendability and subsequent protection against the formation of aggregates either into a magnetic field or into the blood stream but also contribute to the binding of various ligands (fluorescent dyes for optical imaging, chelators for MRI/nuclear imaging, targeting moieties, or even drugs) to the NP surface (Titirici et al. 2006; Wang et al. 2007). The applied surface functionalization strategies include either inorganic or organic materials (Wu et al. 2008). In the case of inorganic coating, IONPs are modified at their outer shell by a layer such as silica, gold, gadolinium(III), or carbon. For instance, a surface enriched in silica enhances the presence of silanol groups, which can easily react with various coupling agents to covalently attach specific ligands to these magnetic particles. More specifically, the agents 3-aminopropyl-triethoxysilane (APTES), p-aminophenyl trimethoxysilane (APTS), and mercaptopropyltriethoxysilane (MPTES) are mainly employed for introducing the amino and sulfhydryl groups (Shen et al. 2004). The mechanism of silane coating is depicted in Figure 17.4.
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
Published in Pharmaceutical Development and Technology, 2021
Muhammad Kawish, Tooba Jabri, Abdelbary Elhissi, Hina Zahid, Kanwal Muhammad Iqbal, Komal Rao, Jasra Gul, Muhammad Abdullah, Muhammad Raza Shah
Surface functionalized MNPs with LBA was synthesized in two steps. First, narrow size MNPs were synthesized by precipitating Fe(II) (0.278 g) and Fe(III) (0.540 g) solutions in an alkaline medium adjusted with NH4OH (1 M, 30 ml) by a standard co-precipitation technique (Saad et al. 2017). MNPs (0.1 g) were subjected to silane coating with 3-aminopropyl triethoxysilane (APT) (0.3 g, 317 μL)through silanization reaction (Abdelkader and Lockwood 2011). LBA attachment to amino coated MNP was achieved with slight modifications by adapting a previously published protocol (Agnaniet et al. 2003; Selim et al. 2007; Pan et al. 2016). Briefly, LBA (0.45 g) is added to DMF containing a mixture of DCC (0.250 g) and DMAP (0.005 g) followed by stirring for 10 min under argon (Ar) atmosphere. Then, amino-functionalized MNPs (0.153 g) was added to the mixture and further stirred for 24 h. The resultant surface-functionalized MNPs were washed with DMF and dried at −20 °C on freeze dryer (Vritis 25 SRC, USA) overnight. CFT loading was performed in accordance with previously reported protocol (Nosrati et al. 2018; Katuwavila et al. 2020). Briefly, different amounts of CFT (1–5 mg) were dissolved in deionized water containing LBA-MNPs (1 mg/mL). The drug-loaded MNP-LBA NPs were removed via centrifugation at 12,000 rpm, and supernatant containing unloaded drug was measured by UV-Visible spectrophotometer at (241 nm). The ratio containing higher loading capacity and narrow size was selected for further analysis.
A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer
Published in Expert Opinion on Drug Delivery, 2020
Tingting Li, Yue Geng, Hanxi Zhang, Jing Wang, Yi Feng, Zhongyuan Chen, Xiaoxue Xie, Xiang Qin, Shun Li, Chunhui Wu, Yiyao Liu, Hong Yang
Tetraethylorthosilicate (TEOS), N-hydroxysuccinimide (NHS), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC), hyaluronic acid (HA), and indocyanine green were purchased from Sigma-Aldrich (St. Louis, MO, USA). (3-Aminopropyl) triethoxysilane (APTES) was purchased from TCI Shanghai (Shanghai, China). Hyaluronidase was obtained from Sangon Biotech Co., Ltd. (Shanghai, China). The iron oxide nanoparticles (10 nm) were obtained from Nanjing Emperor Nano Material Co., Ltd. (Nanjing, China), and doxorubicin (DOX) was obtained from Hisun Pharmaceutical (Zhejiang, China). The L-15 cell culture medium, fetal bovine serum (FBS), 4ʹ,6-diamidino-2-phenylindole dihydrochloride (DAPI) and trypsin were purchased from Gibco (Thermo Fisher Scientific, Waltham, MA, USA). Calcein-AM/PI was purchased from Thermo Fisher Scientific (Waltham, Massachusetts, US). Cetyltrimethylammonium bromide (CTAB), ammonium nitrate, and hexyl alcohol were purchased from Kelong Chemicals (Chengdu, China). All chemicals were used as received without further purification.
4-Formylphenyl boronic acid grafted amino MCM-41 for efficient adsorption of Cu(II) ions in aqueous medium: isotherm, kinetic and optimization studies
Published in Toxin Reviews, 2022
Inderpreet Kaur, Navjot Kaur, Bhupinder Pal Singh, Rajeev Kumar, Jyoti Chawla
Cetyl trimethylammonium bromide (CTAB) and Tetraethoxysilane [TEOS, (CH3CH2O)4Si] were received from Merck Chemicals and employed as template agent and silica precursor, respectively. The organoalkoxysilane, (3-aminopropyl)triethoxysilane [(NH2(CH2)3Si(OC2H5)3)] of 99% purity was obtained from Sigma-Aldrich, India. 4-formylphenylboronic acid was procured from Spectrochem, India. Copper nitrate trihydrate (Cu(NO3)2.3H2O) (SD Fine Chemicals), sodium hydroxide (NaOH), Ethylenediaminetetraacetic acid (EDTA) (CDH Fine Chemicals), and ethanol (Hi Tech Chemicals) were used as received. All reagents and solvents were used without further purification.