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Lifestyle Factors in Cancer Survivorship
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Curcumin, which gives turmeric its yellow color, slows cancer cell growth by blocking the cell cycle, increasing the rate of apoptosis, and selectively inhibits cyclooxygenase 1 and platelet activating factor, preventing the invasion and migration of cells. Animal studies have shown that curcumin counteracted the effect of the carcinogen triclocarban (TCC), an antimicrobial agent occasionally used in household and personal care products. Research conducted at the University of Michigan also found that turmeric helped halt the growth of stem cells that give rise to breast cancer without harming normal breast cells.18
Percutaneous Absorption
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
Ronald C. Wester, Howard I. Maibach
The second assumption is that the dermis does not affect penetration. The problem of compatibility with hydrophobic compounds was discussed earlier with triclocarban. Additionally, Reifenrath16 has compared the penetrability of different thicknesses of skin and has shown the dermis to be the rate-limiting step in the penetration of DDT.
Lifestyle Factors in Cancer Survivorship
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2014
Curcumin, which gives turmeric its yellow colour, slows cancer cell growth by blocking the cell cycle, increasing the rate of apoptosis, selectively inhibits cyclooxygenase 1, platelet activating factor, and preventing the invasion and migration of cells.109–114 Animal studies have shown that curcumin counteracted the effect of the carcinogen triclocarban (TCC), an anti-microbial agent occasionally used in household and personal care, products.115 Research conducted at the University of Michigan also found that turmeric helped halt the growth of stem cells that give rise to breast cancer without harming normal breast cells.116
Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison
Published in Xenobiotica, 2020
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Scott L. Watson, Rodney W. Snyder, Vicki Sutherland, Jason Stanko, Timothy R. Fennell
Triclocarban (3,4,4′-trichlorocarbanilide) is a residue-producing antibacterial agent that was found in soaps, detergents, health and skincare products, and household cleaners typically up to 1.5%. As it was being used as a replacement for triclosan, production of triclocarban increased from 10,000 pounds in 1986 to as much as 10 million pounds in 2002, making it a high production volume chemical (https://comptox.epa.gov/dashboard/chemical_lists/EPAHPV). However, following the issuance of a proposed rule by the U.S. Federal Drug Administration (FDA) in 2013 regulating its usage due to potential health risks such as bacterial resistance, the production declined to <25,000 pounds in 2014 (EPA, 2019). Under the FDA’s proposed rule, the manufacturers were required to provide to the FDA additional data on the safety and effectiveness of the antibacterial agents used in consumer products. Due to failure of the manufacturers to submit this data to the FDA, in September 2016, the FDA finalized the rule banning 19 antimicrobial agents, including triclocarban, in over-the-counter (OTC) consumer antiseptic wash products (hand wash, body wash, and bar soap) which went into effect in September 2017 (21 C.F.R. § 330.545) (FDA, 2020). Though banned in consumer wash products in the U.S., triclocarban is still used in other countries (Yun et al., 2020).
Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved
Published in Gut Microbes, 2020
Haixia Yang, Katherine Z. Sanidad, Weicang Wang, Minhao Xie, Min Gu, Xiaoqiong Cao, Hang Xiao, Guodong Zhang
Triclocarban (3,4,4ʹ-trichlorocarbanilide, TCC) has been used as an antimicrobial ingredient for more than 60 years, and is incorporated into many consumer products such as bar soaps, deodorants, and detergents.10 Each year, U.S. consumers are exposed to approximate 500,000 pounds of TCC from personal care products.10 The 2013–2014 National Health and Nutrition Examination Survey showed that 36.9% of the urine samples in the U.S. contained TCC.11 The majority of used TCC is ultimately released into the environment leading to widespread pollution. As a result, TCC was listed as a top-10 contaminant in U.S. rivers.10 More alarmingly, recent studies showed that environmental TCC could be efficiently taken up by food crops, leading to the bioaccumulation of TCC and potential human exposure through food consumption. Notably, Mathews et al. showed that some common food crops, such as broccoli, potato, beat, cabbage, and pepper, can accumulate >100 ppm TCC in the root tissues, and onions can accumulate >800 ppm TCC in the bulbs.12 The results from this study are supported by many other investigations.13-20 Together, the ubiquitous presence of TCC has raised concern about its impact on the environment and human health.