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Transformation of Natural Products by Marine-Derived Microorganisms
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Thayane Melo de Queiroz, André Luiz Meleiro Porto
The biotransformation of geraniol by the fungus Thielavia hyalocarpa, isolated from sediments of Suncheon Bay (Korea), resulted in the formation of 1-O-(α-D-mannopyranosyl)geraniol (Figure 5.5). These biotransformation experiments were carried out in culture medium containing soytone (0.1%), soluble starch (1.0%), mannose (0.1%), and sea water, and they were incubated in an orbital shaker (130 rpm, 29°C) for 14 days. The yield of the product 1-O-(α-D-mannopyranosyl)geraniol has not been reported. The biotransformation product was characterised by NMR (Yun et al., 2015).
Microbial and metabolic features associated with outcome of infliximab therapy in pediatric Crohn’s disease
Published in Gut Microbes, 2021
Yizhong Wang, Xuefeng Gao, Xinyue Zhang, Fangfei Xiao, Hui Hu, Xiaolu Li, Fang Dong, Mingming Sun, Yongmei Xiao, Ting Ge, Dan Li, Guangjun Yu, Zhanju Liu, Ting Zhang
As to the ITS data, the average counts per sample are 278,523, ranging from 6,955 to 117,618. We obtained a total of 828,553 ITS2 gene sequences spanning a total of 1,250 fungal OTUs. No statistically significant difference in the alpha diversity of fungal community was detected between samples from pediatric CD patients and HS (Figure S1d). In addition, no clear separation was observed between fungal community structure of CD and HS (Figure 1c). The fungal microbiome was dominated by phyla As comycota and Basidiomycota in both the pediatric CD patients and HS (Figure S1e), and the most commonly observed genera were Saccharomyces, Candida, Aspergillus, and Gibberella (Figure S1f). Compared to that of HS, fecal samples from the pediatric CD patients exhibited higher relative abundances of Alternaria and Thielavia, and lower relative abundances of Botryotinia, Coprinellus, Eupenicillium, Exophiala, Geosmithia, Hyphopichia, Myrmecridium, Phellinidium, Trichosporon, and Wicherhamomyces (Figure 1d).
Marine natural products as antifouling molecules – a mini-review (2014–2020)
Published in Biofouling, 2020
Ling-Li Liu, Chuan-Hai Wu, Pei-Yuan Qian
(+)-Sclerotiorin (53) was first isolated from the fungal strain Penicillium sclerotiorum (CHNSCLM-0013) by Maccurin and Reilly (1940). The chemical structure of 53 was characterized as a γ-lactone, a conjugated ketone, a chlorine atom at C-5 and a branched C-7 side chain. This compound inhibited settlement of cyprids of the barnacle A. amphitrite, with an EC50 value of 5.6 μg ml−1 (Wei et al. 2017). Eleven new and four known thielavins were isolated from an ethyl acetate (EtOAc) extract of the marine-derived fungal strain Thielavia sp. UST030930-004. Thielavins A (54), H (55), W–Y (56–58) and Z2–Z7 (59–64) were active against cyprid settlement of A. amphitrite, with EC50 values ranging from 1.2 to 36.3 μg ml−1 (Table 1). The inhibitory effect of compounds 56–58 and 60 was notably reversible (Han et al. 2017).