Sterane

Sterane

Annexes

Published in Claude Leray, Dietary Lipids for Healthy Brain Function, 2017

Cholesterol (Figure 7.9), as phytosterols or sterols, belongs to the large group of steroids. All derive from squalene, after formation of a core with four cycles, the sterane core. Cholesterol may be the source of many other compounds, such as steroid hormones, bile acids, and vitamin D.

Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives

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Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021

Maša Sinreih, Rebeka Jójárt, Zoltán Kele, Tomaž Büdefeld, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik Rižner

In summary here, we can say that there was no formation of new hydrogen or halogen bonds with the flexible loops that might have been responsible for the selectivity, although hydrophobic interactions might have particularly important roles in the selectivities of these compounds. Hence, the variations of atoms at positions 2 and 4 in the sterane skeletons might fine-tune these effects.

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Annexes

Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives