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Plant Alkaloids and Their Derivatives Relevant to Alzheimer’s Disease
Published in Atanu Bhattacharjee, Akula Ramakrishna, Magisetty Obulesu, Phytomedicine and Alzheimer’s Disease, 2020
Atanu Bhattacharjee, Akula Ramakrishna
Bioactivity-guided fractionation of a tuber extract of Stephania venosa (Family: Menispermaceae) isolated stepharanine, cyclanoline, and N-methyl stepholidine [Figure 17.2 (xxi, xxii) & (xxiii)], which exhibited inhibitory activity toward AChE, with IC50 values of 14.10 ± 0.81, 9.23 ± 3.47 and 31.30 ± 3.67 μM, respectively (Cousin et al., 1996).
Phytoextracts and Their Derivatives Affecting Neurotransmission Relevant to Alzheimer’s Disease
Published in Akula Ramakrishna, Victoria V. Roshchina, Neurotransmitters in Plants, 2018
Protoberberine alkaloids: Stepharanine, cyclanoline and N-methyl stepholidine:Bioactive-guided fraction of tuber extract of Stephania venosa (Family: Menispermaceae) produced stepharanine, cyclanoline, and N-methyl stepholidine [Figure 21.3 (xxi, xxii, and xxiii)], which exhibited inhibitory activity on AChE with IC50 values of 14.10 ± 0.81, 9.23 ± 3.47 and 31.30 ± 3.67 μM, respectively (Cousin et al., 1996).Tubocurarine:Tubocurarine [Figure 21.3 (xiv)] obtained from Chondodendron tomentosum (Family: Menispermaceae) showed AChE inhibitory activity in vivo (Thandla, 2002).
Herbal Medicines in Neuropsychiatric Illness: The Case of L-Stepholidine
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Nitin Sati, Kedar S. Prabhavalkr, Sridhar Natesan, Lokesh K. Bhatt
The chapter discusses the case of an herbal compound (L-stepholidine) extracted from the Stephania genus, a flowering plant in the family Menispermaceae, native to eastern and southern Asia and Australasia.45 They are perennial vines and the name Stephania refers to the anthers being arranged in a crown-like manner from the Greek language. L-stepholidine interacts with the dopaminergic system and hence in the next section, the role of dopamine and other neurotransmitters involved in neuropsychiatric illness has been described.
Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy
Published in OncoImmunology, 2021
Jing Sun, Run Shi, Xiaowen Zhang, Da Fang, Josefine Rauch, Shun Lu, Xuanbin Wang, Lukas Käsmann, Jing Ma, Claus Belka, Chuan Su, Minglun Li
Recent polypharmacology studies suggest the need to design compounds that target multiple genes or molecular pathways. A list of top 150 upregulated genes in IRS-high samples were submitted to CMap to identify potential drugs applicable for IRS-high patients. CMap mode-of-action (MoA) analysis revealed 39 mechanisms of action shared by 50 compounds with the highest prediction scores (Figure 7i). In particular, four compounds, namely GR-103691, trifluoperazine, l-stepholidine and fluphenazine, shared the MoA of dopamine receptor antagonist. Their chemical structural formulas were shown in supplementary Figure 7a-D, and a common target named HRH1 was shared by the four compounds (supplementary Figure 7e).
Resistance is not futile: treatment-refractory schizophrenia – overview, evaluation and treatment
Published in Expert Opinion on Pharmacotherapy, 2019
D-amino acid oxidase inhibitors (DAAOI-1 and DAAOI-2) are NMDA enhancing agents that are being investigated in phase II clinical trials as adjunctive treatment for TRS. Other medications are being studied on the residual negative and cognitive symptoms of schizophrenia. Some of these medications have included: roluperidone (MIN-101), encenicline (EVP-6124), erteberel (LY500307), TAK-831, AVN-211, sodium benzoate, ADX-71149, eltoprazine, stepholidine, and GTS-21 [159–161].
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats
Published in Xenobiotica, 2022
Liyuan Zhu, Jiahua Mei, Chaorui Peng, Yuancui Zhao, Yunkuan Liu, Lili Cui, Kun Zhang, Yunshu Ma
The internal standard method was selected as the analysis method of biological samples. Chromatography conditions, peak shape, and extraction recovery were selected as indexes, crebanine, nuciferine, stepholidine, and sinomenine were compared as the internal standards. The results showed that sinomenine was the best choice, with stable and relatively high extraction recovery, satisfactory peak shape, and the peak time was similar to that of sinoacutine.