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Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Sarwar Beg
Sinomenine is an alkaloid isolated from the Sinomenium acutum plant, which is traditionally used in herbal medicine in Japan and China for RA. Other compounds isolated from the plant include madecassoside, asiaticoside, Asiatic acid, and centelloside. Sinomenine I.P administration of sinomenine suppressing MMP-2, MMP-9, and IL-6 in the animal model of arthritis. A recent study reported that asiaticoside successfully exhibits anti-inflammatory potential by CIA mice. After oral administration of madecas-soside at 10, 20, and 40 mg/kg body weight (BW) dose in CIA mice, the histopathology revealed that inflammatory cells infiltration and synovial hyperplasia helps in providing protection against joint destruction (Tong et al., 2015).
Hyaluronidase and Gelatinase (MMP-2, MMP-9) Inhibitor Plants
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
C. Donmez, G. D. Durbilmez, H. El-Seedi, U. Koca-Caliskan
Several studies about phytochemical MMPs inhibitors have been published. “A prenylated chalcone derived (xanthohumol) from Humulus lupulus L.”, “Flavonoid glycosides (isorhamnetin 3-O {cyrillic}-β-d-glucoside and quercetin 3-O-β-d-glucoside) from Salicornia herbacea”, “Rhizoma Paridis saponins/Resveratrol/saponin derived from Platycodon grandiflorum” have important inhibitory role in metastasis of cancer by restricting the expressions of MMP-2 and -9.24,26,38,48 It is reported that catechin, gallic and protocatechuic acid, epicatechin (EC), epi-gallocatechin gallate (EGCG), caffeic acid, and rutin have chemoprotective effects due to the inhibition of MMP-2 and -9 protein expressions.10,68 “4-Nerolidylcatechol isolated from Pothomorphe umbellata (L.) Miq.” reduces expression of MMPs that increases with ultra-violet radiation.6,47 “Sinomenine isolated from Sinomenium acutum” shows inhibitory effects in inflammatory autoimmune diseases.54
Nanocarriers Systems and Their Application for the Delivery of Different Phytoconstituents
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Ebru Altuntaş, Gülgün Yener, Burcu Özkan
Sinomenine (7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one) is an alkaloid derived from the Sinomenium acutum Rehd. and Wils which has been applied for curing rheumatic arthritis in Chinese medicine since ancient times (Song et al., 2013). Current pharmacology studies have shown that a hydrochloride chemical form of sinomenin (SH) (Xu et al., 2008) has various pharmacological activities, specifically in anti-angiogenic, anti-immune, and anti-inflammatory effects (Liu et al., 1994, 1996, Mark et al., 2003, Zhang et al., 2015, Zuo et al., 2015). Thus, SH is a valuable type of phytochemical which has promising development possibilities. On the other hand, administration of SH via oral route is limited by its gastrointestinal side effects and poor bioavailability (3%–4%) (Takeda et al., 1995). In a study carried out by Yan et al. (2016), SH loaded ethosomes (SE) were formulated by the injection method for transdermal administration of SH. Uniform design and single factor testing were applied to optimize the SE formulation. In vitro skin permeation and SE deposition were measured, and skin irritation was assessed in the Draize test. Consequently, the in vivo anti-inflammatory capacity of SE was investigated by the xylene-induced ear edema test. Finally, the optimized SE has an average particle size of 157.08 ± 11.72 nm with a polydispersity index of 0.23 ± 0.04 and a negative charge of −14.9 ± 1.9. The dermal penetration and SH deposition of SE were 663.8 and 18.5 mg/cm2, respectively. Cutaneous irritation research proved that SE has a desirable cutaneous tolerability. In addition, an important inhibitory impact on ear edema (30.01%) was obtained by SE. In conclusion, SE has been demonstrated to be a beneficial dosage form for dermal drug delivery of SH and has a high potential in treatment of local inflammation.
Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis
Published in Journal of Chemotherapy, 2023
Lung carcinoma is a prevalent malignancy with high mortality throughout the world. NSCLC is the most common lung cancer subtype with a poor prognosis and low 5-year survival [1–4]. Chemotherapy is an effective strategy to improve the clinical outcomes of advanced lung cancer patients [5]. However, a large fraction of patients developed drug resistance, which greatly limited the clinical applications of chemotherapeutic drugs. Sinomenine is an active alkaloid which isolated from the Chinese medicinal plant Sinomenium acutum [15]. Recently, studies revealed that sinomenine displayed an effective antitumor activity against diverse cancers [15]. Moreover, studies have demonstrated that sinomenine facilitate cisplatin sensitivity of gastric cancer cells through negative regulating the PI3K/AKT/Wnt signalling pathway [20]. In this study, the biological roles of sinomenine in cisplatin resistant NSCLC cells were investigated. We observed the combination of sinomenine and cisplatin synergistically inhibited lung cancer viability.
Hexagonal liquid crystalline system containing cinnamaldehyde for enhancement of skin permeation of sinomenine hydrochloride
Published in Pharmaceutical Development and Technology, 2022
Jingbao Chen, Wu Long, Baoqi Dong, Wenxuan Cao, Xu Yuhang, Yun Meng, Chu Xiaoqin
Sinomenine (SIN) is a natural alkaloid extracted from the rhizome of the plant Sinomenium acutum, which has been used for medicinal purposes in China for over 2000 years. Sinomenine hydrochloride (SH) is a hydrochloride salt of SIN, due to its excellent anti-inflammatory and immunosuppressive properties, the commercially available products of SH such as oral tablets and pills have been approved by the Chinese government for RA treatment (Xu et al. 2008). However, SH has exceedingly low oral bioavailability and a relatively short biological half-life period. Previous publications have shown that long-term oral administration of SH can cause severe gastric mucosal damage, liver and kidney damage, and certain toxicity to the heart (Wang et al. 2021). Hence, it is necessary to explore new strategies to deliver SH, one of which is the Transdermal drug delivery system (TDDS).
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats
Published in Xenobiotica, 2022
Liyuan Zhu, Jiahua Mei, Chaorui Peng, Yuancui Zhao, Yunkuan Liu, Lili Cui, Kun Zhang, Yunshu Ma
Sinoacutine (Figure 1(A)) is an active isoquinoline morphine alkaloid, which is obtained by extraction and separation from Stephania yunnanensis H. S. Lo. As an herbal medicine, S. yunnanensis is used for antipyretic, analgesic, anti-inflammatory, and haemostasis by Dai, Yi, and other ethnic minorities and folks in Yunnan, China. The structure of sinoacutine is very similar to that of Sinomenine (Figure 1(B)), which is extracted from the roots and stems of Sinomenium Acutum. Drugs marketed in China consisting of sinomenine, Zhengqing Fengtongning Injections, and tablets, can be used to treat rheumatic arthritis and rheumatoid arthritis, and relieve muscle pain and joint swelling pain (Huang et al. 2019; Xuan et al. 2020). Studies have found that sinomenine has a wide range of pharmacological effects, including analgesic (Gao et al. 2021), anti-inflammatory (Zeng and Tong 2020; Liao et al. 2021; Yi et al. 2021), anticonvulsant (Ramazi et al. 2020), anticancer (Bai et al. 2021; Qu et al. 2021; Zhao et al. 2021), antiarrhythmic (Dh et al. 1985), antidepressant (Liu et al. 2018), and alleviating the symptoms of liver injury and lung injury (Chen et al. 2020; Wang et al. 2020).