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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A 61-year-old woman had a several-year history of episodic red eyes and periorbital rash. A month before presentation, she discontinued use of contact lenses, antihistamine eye drops, sunscreen, and cosmetics but continued to use shea butter on the face. Patch testing was positive to eye drops containing ketotifen and negative to its ingredient benzalkonium chloride. Ketotifen itself was not tested and neither was the other ingredient, glycerin (9).
Common Cosmetic Ingredients: Chemistry, Actions, Safety and Products
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Shea butter is produced from the fatty component of the seed of the shea tree (Vitellaria paradoxa Gaertner). Shea butter contains a number of different components depending on the origin of the tree it is extracted from, including TriglyceridesSaturated and unsaturated fatty acids, for example, stearic acid and oleic acidPolycyclic triterpenesAlpha, beta, gamma and delta forms of tocopherol (vitamin E); shea butter produced from shea trees in hotter climates produce the greatest amount of vitamin E (Maranz and Wiesman, 2004)Polyphenols such as gallic acid, cathchin and quercetin (Maranz et al., 2003)
African Medicinal Plants and Traditional Medical Knowledge
Published in Charles Wambebe, African Indigenous Medical Knowledge and Human Health, 2018
Gerard Bodeker, Emma Weisbord, Drissa Diallo, Robert Byamukama, Yahaya Sekagya, Charlotte I.E.A. van't Klooster
These sacred groves are home to varied species, including the shea tree (Vitellaria paradoxa C.F. Gaertn, Sapotaceae), a species that is indigenous to Africa and is a traditional African food plant. The shea fruit contains nutritious pulp and an oil-rich seed from which shea butter is extracted. Some of the constituents of shea butter are reported to have anti-inflammatory, emollient, and humectant properties (Pobeda and Sousselier, 1999). In Ghana, shea butter is used as lotion to protect the skin during the dry season (Goreja, 2004), while in Nigeria shea butter is used for the management of sinusitis and relief of nasal congestion (Tella, 1979).
Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients
Published in Journal of Dermatological Treatment, 2023
Carlo Gelmetti, Corinna Rigoni, Alessandra Maria Cantù, Antonina Agolzer, Alice Agrusa, Michela Brena, Federica Dall’Oglio, Patrizia Demichelis, Sandra Farina, Lucretia Adina Frasin, Sandra Lorenzi, Giuseppina Mazzola, Marisa Praticò, Stefania Robotti, Aurora Tedeschi, Lucia Villa, Prodromos Ananiadis, Eirini Arkoumani, Iulia Astashonok, Eulalia Baselga Torres, Sidita Borici, Elna Cano, Rozana Cela, Amarda Cengo, Francisca Corella, Xavier Cubiro Raventos, Miriam America De Jesus Silva, Ermira Demiraj, Entela Dhima, Xhiljola Doci, Anna Domarad, Marina Didyk, Albana Dyli, Ourania Efthimiou, Georgia Filippi, Víctor-Adrian Flores Climente, Maria Pilar Garcia Muret, Javier Garcia Navarro, Migena Gega, Aristea Noura Giakoub, Vasileios Giakoubis, Amarda Gica, Marjeta Gjomema, Blerina Guri, Elmijola Janushaj, Antonios Kanelleas, Georgia Kanelopoulou, Entela Kapaj, Dorothea Kapoukranidou, Konstantina Karadima, Athina Katsavou, Lena Kotrulja, Aikaterini Kyriakou, Georgios Larios, Anna Lopez, Cristina Lopez, Sofia Magdalini Manoli, Tatiana Matvienko, Liljana Mervic, Konstantinos Mileounis, Diana Muja, Milkota Nadezhda, Despoina Panagioti, Markos Papakonstantis, Maria Papanikou, Despoina Papathemeli, Kyriaki Papigkioti, Violetta Pivak, Driada Preza, Esther Roé, Mirjam Rogl Butina, Esther Serra Baldrich, Dimitrios Sgouros, Aleksandra Shilova, Eljona Shllaku, Nikolaos Sideris, Ermal Sina, Ardiana Sinani, Fani Sourli-Chasioti, Mirsa Stankaj, Dimitra Tasioula, Athanasios Tsalmadoupis, Fragkiski Tsatsou, Eftichia Tsenebi, Anastasia Tsitlakidou, Politimos Vassis, Eva Vilarrassa, Olga Vorobey, Nikolaos Voutsakis, Svetlana Yakovleva, Svetlana Yakubovskaya, Ekaterina Yerygina, Alexios Zarras, Valbona Zenelaj, Olga Zenko
While the attack on the immunological side of Atopic Dermatitis had a first major success with the advent of dupilumab, the attack on the dermatological side was lagging behind. On the one hand, topical crisaborole has proved relatively inefficient and not well tolerated by a not inconsiderable percentage of patients (and in any case it is a drug available in very few countries, as well as having a very high price). On the other hand, the use of probiotics on the skin is currently fraught with legal and conceptual problems (16,17). This obstacle has been overcome by the topical use of prebiotics and postbiotics (18–20), which do not have the limitations of probiotics. In addition to classic moisturizing substances such as sodium lactate, glycerin and shea butter and anti-itch substances such as niacinamide, vitamin E and dipotassium glycyrrhizinate, the product under investigation contains a prebiotic (alpha-glucan oligosaccharide) and a postbiotic (lactobacillus ferment).
An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?
Published in Expert Opinion on Drug Discovery, 2020
Kam Lun Hon, Steven Loo, Alexander K. C. Leung, Joyce T. S. Li, Vivian W. Y. Lee
Hon et al. investigated a number of commercial products, including a proprietary cream (Ezerra®, HoePharma, Malaysia) for AD [38,61]. Patients who accept a proprietary cream generally are less itchy and have improved quality of life than non-accepting patients. The cream with shea butter extract was similar in efficacy to a product with ceramide-precursor. Hence, patient acceptability is always important to ensure treatment success. There are few clinical trials to document the clinical efficacy in most of the commercial moisturizers [53,56]. A recent Cochrane review on moisturizer trials demonstrated that most moisturizers had some beneficial effects but there is generally no evidence that one product is superior to another [62].
Real-life efficiency and safety comparison study of emollient ointment based on glycerophosphoinositol (GPI) salt of choline and other emollient products in patients with atopic dermatitis
Published in Journal of Dermatological Treatment, 2022
Plant-derived products are very often components of emollients. The most common are: colloidal oatmeal, aloe vera, shea butter, horse oil and coconut oil or virgin coconut oil (25). Verallo-Rowell et al. (26) and Evangelista et al. (27) showed that virgin coconut oil significantly reduced AD severity and was used for antibacterial properties. Moreover, in their study, Lisante et al. (28) described properties of colloidal oatmeal in the management of mild to moderate AD in children. Compared to the previously described components of emollients of plant origin, GPI salts have been poorly described so far, which makes them a relatively new component that requires further research.