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Induction of Anesthesia
Published in Michele Barletta, Jane Quandt, Rachel Reed, Equine Anesthesia and Pain Management, 2023
Kristen Messenger, Rachel Reed
Inhalants: Induction using only an inhalant is rarely performed. If and/or when it is indicated in adult horses, special equipment such as a tilt table is required to prevent injury to personnel and the patient.It can be performed more safely in a neonate.Sevoflurane is generally recommended because of rapid onset and less airway irritation. It is also easily titrated to effect due to low solubility of the agent. However, it is more expensive compared to isoflurane.
General Anesthetics
Published in Sahab Uddin, Rashid Mamunur, Advances in Neuropharmacology, 2020
Aman Upaganlawar, Abdulla Sherikar, Chandrashekhar Upasani
Being lower blood and other tissue solubility, sevoflurane produces anesthesia at a rapid rate. Sevoflurane (3% of absorbed) undergoes hepatic metabolism by CYP2E1 to hexafluoroisopropanol as a major metabolite as well as produces inorganic fluoride. The compound A, that is, pentafluoroisopropenyl fluoromethyl ether is produced due to an interaction of sevoflurane with soda lime as a decomposition products (Hanaki et al., 1987; Kharasch and Thummel, 1995).
Anaesthesia for ECT
Published in Alan Weiss, The Electroconvulsive Therapy Workbook, 2018
Sevoflurane is a volatile inhaled anaesthetic agent that is restricted to the operating room making it unavailable when ECT is administered in standalone or remote settings. There have been a number of studies that have compared the acute haemo-dynamic response of sevoflurane and thiopentone during ECT. Sevoflurane at high dose (3.4%) or mixed with nitrous oxide (50%) was more effective than thiopentone in blunting the cardiovascular effects during ECT (Tanaka et al., 1997). The impact on seizure quality was not recorded but seizure length and recovery time were similar to thiopentone although set-up time was longer (Tanaka et al., 1997). Volatile anaesthetic agents may have a role in providing ECT safely to women in late-stage pregnancy as it can reduce post-ECT-induced contractions (Ishikawa et al., 2001).
Co-expression prognostic-related genes signature base on propofol and sevoflurane anesthesia predict prognosis and immunotherapy response in glioblastoma
Published in Annals of Medicine, 2023
Zhiqi Hou, Dexing Luo, Huanhuan Luo, Qiang Hui, Yongqing Xu, Xiaofeng Lin, Zhibin Xu
Propofol is a widely used intravenous anesthesia drug with a rapid onset of action and can be used for anesthesia induction and anesthesia maintenance. Some studies have found that propofol used in neurosurgery can play a certain role in brain tissue protection, but excessive use may lead to cardiac or respiratory depression [31]. Propofol not only has obvious sedative effects, but also protects organ function, inhibits platelets and regulates the release of immune factors [32]. Sevoflurane is an inhaled anesthetic drug, mainly metabolized by the respiratory tract and lungs. It has the characteristics of rapid induction of anesthesia, shorten recovery time, and no toxic side effects. It often uses in clinical induction of respiratory anesthesia [33]. Studies have found that sevoflurane can inhibit the proliferation and migration of cancer cells in vitro. Therefore, anesthesia methods or anesthetic drugs may have a certain impact on postoperative recurrence, survival and outcome of tumor patients. The use of anesthetic drugs or anesthesia methods that have a certain inhibitory effect on tumor cell proliferation and invasion may reduce tumor cell metastasis and dissemination during surgery, thereby reducing the probability of tumor recurrence or metastasis [34].
Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1
Published in Toxicology Mechanisms and Methods, 2023
Lingang Wang, Hui Zhang, Chenyao Xie
Sevoflurane, is the most frequently used inhalation anesthetic for fetal and neonatal surgery during pregnancy and has the advantages of good respiratory tolerance, strong anesthetic efficacy, maintenance of hemodynamic stability, and low liver and kidney toxicity (Edwards et al. 2010; Gibert et al. 2012). Therefore, it is widely as the anesthesia of choice in pediatric and obstetric surgery. However, recent studies have confirmed that sevoflurane has important effects on the function and structure of the nervous system in rapidly developing infants and young children, causing cognitive dysfunction (Wilder et al. 2009). Relevant animal studies have also revealed that sevoflurane anesthesia induced neuronal apoptosis, causes a persistent decrease in long-term memory and learning in neonatal rats (Jevtovic-Todorovic et al. 2003). However, the specific regulatory mechanisms responsible for this is unclear.
Study on the ameliorating effect of miR-221-3p on the nerve cells injury induced by sevoflurane
Published in International Journal of Neuroscience, 2021
Qirui Wang, Xin Tian, Qijuan Lu, Kun Liu, Jiekun Gong
In recent years, the continuous improvement of anesthesia technology has enabled more and more surgical operations and invasive examinations to be carried out smoothly [1, 2]. Anesthesia is divided into local anesthesia and general anesthesia, and the general anesthesia includes inhalation anesthesia or intravenous anesthesia [3, 4]. Sevoflurane is the most widely used inhalation anesthetics in clinical practice, which has the advantages of rapid effect, good controllability and low airway irritation [4, 5]. However, recent studies have proved that sevoflurane exposure has toxic effects on the central nervous system, which can lead to abnormal apoptosis of neurons and neurodegeneration [6, 7]. It is mainly manifested in the decline of cognitive functions such as learning and memory [8–10]. Therefore, it is important to study the therapeutic methods to reduce the neurocognitive impairment induced by sevoflurane.