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Nutrition and Nutritional Supplements in the Management of Dyslipidemia and Dyslipidemia-Induced Cardiovascular Disease
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Sesame seeds and oil at 40 g/day reduce LDL-C by 9% through inhibition of intestinal absorption and increased biliary secretion of cholesterol [109,110]. Sesame also decreases HMG-CoA reductase activity and upregulates the LDL receptor gene, 7-alpha hydroxylase gene expression, and sterol regulatory element-binding proteins (SREBP) 2 genes [109,110]. A randomized placebo-controlled crossover study of 26 postmenopausal women who consumed 50 g of sesame powder daily for 5 weeks had a 5% decrease in TC and a 10% decrease in LDL-C (109).
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Sesame seed is the seed of the plant Sesamum indicum, family Pedaliaceae. Similar to flaxseed, sesame seed is rich in oil, omega-3 alpha-linolenic acid, omega-6 fatty acids, vitamin E, fibers, phytic acid, proteins, and minerals. Sesame seeds and oil also contain a lot of lignans (non-flavonoid polyphenols), particularly sesamin and sesamolin, substances that may help lower blood cholesterol levels, and may have antihypertensive, immunoregulatory, anticarcinogenic, and anti-aging activities (156–157). Sesame seeds and oils might prevent some cardiac diseases and inflammation such as atherosclerosis and arthritis (156–157). However, sesame seed and oil can cause allergy, including anaphylaxis. Sesame seed and oil are used as ingredients in various cuisines in the world (Mexico, Eastern Asia, Middle Eastern, etc.).
Osteoarthritis
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Sesame oil has been used in traditional medicine to alleviate pain from inflammatory conditions. The oil is extracted from Sesamum indicum, and animal OA models show an ability for sesame oil to alleviate joint pain by inhibiting oxidative progression and serum inflammatory markers (Dragos et al., 2017). Human studies show that five tablespoons of sesame seeds in conjunction with standard drug therapy for OA led to improvement in pain and mobility after 2 months compared to control (Sadat et al., 2013). And in another study, the same amount of sesame seed was associated with a statistically significant drop in serum levels of IL-6 and C-reactive protein after 2 months of treatment (Haghighian et al., 2015).
Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway
Published in Nutritional Neuroscience, 2021
Waralee Ruankham, Wilasinee Suwanjang, Prapimpun Wongchitrat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Sesame is widely known as a traditional medicine for treatment of various disorders including wound healing17, hyperlipidemia18, hypercholesterolemia19, and infertility20, as well as beauty enhancements.21–23 Both sesame seeds and oil are considered safe as food and ingredients in functional foods and nutraceuticals. The most abundant phenolic compounds found in sesame seeds and oil are sesamin and sesamol. These two compounds are reported to have many pharmacological properties. Several lines of evidence from a variety of in vivo and in vitro studies have revealed that the mechanisms underlying neurodegeneration remain to be fully elucidated.
Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl4-induced oxidative stress-mediated liver damage in rats
Published in Drug and Chemical Toxicology, 2022
Sunil Chikkalakshmipura Gurumallu, Tareq Aqeel, Ashwini Bhaskar, Kannan Chandramohan, Rajesha Javaraiah
Sesame seed (Sesamum indicum L.) (SS) contains 18–25% protein and carbohydrates, 50–60% oil, which is composed of 36.4–42.1% of LA, an ω-6 FA, 16.3% of SFAs and appreciable amounts of lignans viz sesamin, sesamolin and sesaminol (Gharby et al.2017). Linoleic acid is reported to offer protection against cancer, cardiovascular diseases, obesity, osteoporosis, immunomodulatory reactions, and oxidative stress (Basiricò et al.2017).
Design and fabrication of Sesamol-loaded transfersomal gel for wound healing: physicochemical characterization and in-vivo evaluation
Published in Drug Development and Industrial Pharmacy, 2023
Nida Umam, Mohammad Ahmad, Poonam Kushwaha
Wounds result from the destruction of the normal anatomically lining tissue membrane, which includes trauma, tissue resection, and burns [1]. Wounds that become chronic due to co-existing conditions like diabetes or peripheral vascular disease may not heal promptly. In the postoperative period, wound infections may also fail to heal; it is estimated that up to 4% of patients with surgery suffer from such infections. Despite the associated high morbidity associated with chronic non-healing wounds, these wounds add substantially to the costs of medical care [2]. Since the last decade, naturally occurring phenolic compounds have received considerable attention for treating various skin diseases. In addition to their low toxicity, phenolic compounds possess a range of biological activities including antioxidant, anti-inflammatory, and antimicrobial properties. Research suggests that phenolic compounds can accelerate wound healing primarily through their ability to reduce reactive oxygen species (ROS) and inflammation developing in wounds, and as a result promote the induction of skin repair mechanisms [3]. Through clinical and preclinical studies, it has been identified that oxidative damage and inflammation are the main causes of nonhealing chronic wounds [4]. The phenolic compound Sesamol (SL) is a major lignan derived from sesame seeds (Sesamum indicum) and sesame oil. It has many nutritional and health benefits. Traditionally, sesame seed paste and its oil have been used for promoting healing in burns and other wounds. Studies have shown that SL can accelerate wound closure. Wound healing activity is influenced by antioxidants in a positive manner. Sesamol is known to be the main antioxidant contained in processed sesame oil. As a result of its antioxidant activity, it contributes to the repair of injured skin by inhibiting the overproduction of ROS responsible for wound pathogenesis [5]. Additionally, SL promotes cell proliferation by stimulating collagen synthesis and maturation in wound areas [6].