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Regulation of the α2-Macroglobulin Gene
Published in Andrzej Mackiewicz, Irving Kushner, Heinz Baumann, Acute Phase Proteins, 2020
Friedemann Horn, Ursula M. Wegenka, Peter C. Heinrich
Bacterial lipopolysaccharides (LPSs) are very potent agents for evoking an acute phase response in man and in animal models. We isolated nuclear extracts from rats after i.p. injection of LPS and analyzed the DNA-binding proteins by gel retardation assays. As a probe we used a 32P-labeled oligonucleotide comprising the tandem of two α2-M APRE core motifs which conferred strong IL-6 inducibility to a control promoter (see Figure 6). After incubation of nuclear extracts with this probe, the protein-DNA complexes formed were separated by native gel electrophoresis. With liver nuclear extracts from control rats and from rats 30 min after LPS administration, only a very weak, retarded band was observed (Figure 7). One hour after LPS injection, however, the signal increased dramatically, then decreased gradually between 2 and 6 h, and returned to basal levels 10 h after treatment. To reflect the LPS responsiveness and the specific binding to the APRE, we propose to call the factor forming this complex the acute phase response factor (APRF).
Techniques Of Hydrophone Calibration
Published in Marvin C. Ziskin, Peter A. Lewin, Ultrasonic Exposimetry, 2020
where ρ is the density of water in kilograms per cubed meter and c is the sound speed in water in meters per second. Use of the plane-wave intensity response factor is obviously restricted to regions of the ultrasonic field where the plane-wave assumption, that is, where I = p2/ρc, may be considered valid. It is generally accepted that the plane-wave assumption holds in the regions near the focus or in the far field of a source transducer.
Optimal Experimental Designs — New Plans For Drug Combination Studies
Published in Marshall N. Brunden, Thomas J. Vidmar, Joseph W. McKean, Drug Interaction and Lethality Analysis, 2019
Marshall N. Brunden, Thomas J. Vidmar, Joseph W. McKean
The multiplicative theory of interaction in contingency tables was introduced by Roy and Kastenbaum4 when they generalized Barlett’s definition for the 2 × 2 × 2 table. Discussions in the literature of r × s × t contingency tables have each dimension correspond to responses or response factors. Bhapkar and Koch5 discuss the differences between response models and response-factor models.
Prediction of spontaneous coal combustion tendency using multinomial logistic regression
Published in International Journal of Occupational Safety and Ergonomics, 2022
Nilufer Kursunoglu, Maruf Gogebakan
MLR is used to forecast categorical settlement in or the likelihood of category association on a dependent factor according to multiple independent factors. The independent factors can be either binary or continuous (ratio in scale or interval). The MLR model is a quite simple generalization of the binomial logistic regression model and both models are primarily dependent on logit analysis or logistic regression [47,48]. Equation (1) can be used for a response factor (Y) with two categories and an explanatory factor (X): P = probability of models; X = explanatory factors; Y = response factors; x = desired characteristic value; y = whether the desired characteristic is present; p = number of free parameters (explanatory factors);
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer
Published in Expert Opinion on Therapeutic Targets, 2022
Haleema Azam, Lisa Pierro, Martina Reina, William M Gallagher, Maria Prencipe
Serum Response Factor (SRF) is a ubiquitous transcription factor (TF) involved in several cellular processes, including cytoskeletal organization [1,2], cellular proliferation, cell differentiation and cell motility [3]. SRF’s relationship with its many cofactors and regulators makes it tissue specific with its function varying from cell-to-cell type. Several studies show that SRF expression is associated with an aggressive cancer phenotype, leading to worse outcome. This review focuses on SRF’s emerging role as a key contributor to three major hallmarks of cancer: promoting cell proliferation, resistance to cell death, and inducing invasion and metastases. A growing number of studies suggests that targeting the SRF pathway may overcome these hallmarks, representing a promising novel target for cancer therapy.
Evaluation of trace elements concentration in surface sediments of Parishan International Wetland (Fars Province, SW Iran) by using geochemical and sedimentological analysis
Published in Toxin Reviews, 2021
Amir Karimian Torghabeh, Sayed Fakhreddin Afzali, Ashkan Jahandari, Mohamad Hosein Mahmudy Gharaie, Omar Ali Al-Khashman
The potential ecological RI method (Hakanson 1980) is a broadly sedimentological perspective to assess ecological risks due to heavy metals’ pollution in freshwater ecosystems. This sedimentological approach evaluates the sensitivity of biological communities to pollutants in sediments, based on the toxicity of some trace elements, and it also indicates the potential ecological risk caused by heavy metals (El Zrelli et al.2015). It may be calculated using the following equation: i is the toxicity response factor for each of a given trace element (As = 10, Cr = 2, Cd = 30, Zn = 1, Cu = 5, Ni = 1, and Pb = 5); Eir is the potential ecological risk factor for a given trace element; Cfi is the contamination factor, Ci is the concentration of trace elements in the analyzed samples; and Cr is the level of a reference trace elements.