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Postmenopause
Published in Carolyn Torkelson, Catherine Marienau, Beyond Menopause, 2023
Carolyn Torkelson, Catherine Marienau
Premarin became commonly prescribed because it was seen as a way to manage menopausal symptoms and significantly improve women’s lives. Staying “forever feminine and youthful” was touted by some male physicians with sexist attitudes, who prescribed Premarin not only for symptom control but also to keep women youthful. By the 1970s, estrogen replacement therapy was firmly entrenched as the medical treatment for menopause; by 1975, Premarin was the most frequently prescribed drug in the United States.1
DRCOG MCQs for Circuit A Questions
Published in Una F. Coales, DRCOG: Practice MCQs and OSCEs: How to Pass First Time three Complete MCQ Practice Exams (180 MCQs) Three Complete OSCE Practice Papers (60 Questions) Detailed Answers and Tips, 2020
Endometrial cancer is associated with: Combined oral contraceptive pills.Premarin use in the postmenopausal woman with a uterus.Early menopause.Obesity.Multiple pregnancy.
Obstetrics and Gynaecology
Published in Seema Khan, Get Through, 2020
Risk factors for endometrial cancer include nulliparity, late menopause, diabetes, history of unopposed oestrogen administration, oestrogen-secreting tumours of the ovaries and obesity. Premarin is a form of unopposed oestrogen HRT and should be administered to women only post-hysterectomy.
A multicenter, randomized, open, controlled trial to evaluate the efficacy of Honglilai Vaginal Cream and Premarin Vaginal Cream for Genitourinary Syndrome of Menopause in different subgroups of Chinese postmenopausal women
Published in Gynecological Endocrinology, 2022
Mukun Yang, Shouqing Lin, Shurong Zheng, Aijun Sun, Meilu Bian, Shilan Li, Jianli Liu, Lina Hu, Ning Hui, Jing Zhong, Hongchun Hou, Tianfu Yue, Xiaoli Gao, Wenpei Bai
The general health of postmenopausal women is a public issue of worldwide concern [1,2]. Genitourinary Syndrome of Menopause (GSM) is a common affliction involving changes in not only the genital area but also the urinary tract that affects up to 50% of postmenopausal women [3–5]. Its symptoms include vaginal itching, burning, dryness, irritation, and dyspareunia, which affect interpersonal relationships, even urinary and sexual function [5–7]. Studies have shown that GSM is associated with reduced vaginal secretions, vulvovaginal atrophy, and decreased glycogen production by vaginal epithelial cells after menopause, which possibly renders the vagina more susceptible to infections [8]. So far, the first-line treatment of GSM is low-dose, minimally absorbed local estrogen therapy [9–11], which was recommended by the North American Menopause Society (NAMS) and the International Menopause Society (IMS) [12–14]. Premarin vaginal cream is a commonly used estrogenic cream for the treatment of GSM. Honglilai Vaginal Cream is a type of Conjugated estrogens vaginal cream, which has been extracted from pregnant mares’ urine. Honglilai Vaginal Cream has been widely used in China as a local product and its effect has been conformed in several domestic studies. The present study aimed to evaluate the efficacy of Honglilai Vaginal Cream on GSM and screen the targeting patients in different age and menopausal year subgroups in comparison to Premarin vaginal cream.
Prior endogenous and exogenous estrogen and incident dementia in the 10th decade of life: The 90+ Study
Published in Climacteric, 2020
A. Paganini-Hill, M. M. Corrada, C. H. Kawas
In the early 1980s, a health survey was mailed to residents of Leisure World. This survey asked of the women: age at first menstrual period, ever pregnant, age at first child, number of children, age at last menstrual period, hysterectomy, age at hysterectomy, number of ovaries removed, age at first ovary removal, and age at second ovary removal. Questions about estrogen replacement therapy (age started, current use, age stopped) were asked separately for oral, injectable, and cream or suppository estrogens. For Premarin® (the most commonly used oral estrogen), questions asked for all doses taken and that taken for longest amount of time. Total number of years taken were asked for separately for Premarin®, other oral estrogens, injectable estrogens, and cream or suppository estrogens.
Successful pregnancy and childbirth in a patient with acute lymphoblastic leukaemia after busulfan-based myeloablative conditioning allogeneic haematopoietic stem cell transplantation: a case report
Published in Journal of Obstetrics and Gynaecology, 2020
Chen Zhang, Honglan Zhu, Heng Cui, Xiaohong Chang, Zhaohua Wang
In April 2010, she presented to the gynaecological outpatient department of our institution, consulting for menstrual recovery and fertility possibility. She was diagnosed with POF (Table 1). Without any contraindications, she was started on HRT with 0.625 mg Premarin daily and 100 mg micronised progesterone for 10 days per month, presenting with occasional withdrawal bleeding. One year later, due to their withdrawal from Chinese markets, Premarin was replaced by 1 mg Progynova per day. Without withdrawal bleeding, the dose of Progynova was increased to 3 mg per day and the patient achieved 30 day regular menstrual cycles for the next 5 years and 4 months. During this period, the clinical follow-up surveys were conducted by gynaecologists and haematologists. No rejection reactions were observed in the process of HRT.