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Herbal Treatment for Irritable Bowel Syndrome
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Hasya Nazh Ekin, Didem Deliorman Orhan
In general, Plantago species are used due to their anesthetic, antiviral, anti-inflammatory, antihelminthic analgesic, analeptic, antirheumatic, antitumor, antiulcer, diuretic, expectorant effects. In traditional medicine, P. major has been utilized for the treatment of viral diseases (cold, influenza, etc.) and to protect against snake bites. The leaves of the plant contain flavonoids, organic acids, terpenoids, fatty acids, carotenes, and phenolic acids.
Plantago ovata (Isabgol) and Rauvolfia serpentina (Indian Snakeroot)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Ankur Anavkar, Nimisha Patel, Ahmad Ali, Hina Alim
The phytochemicals present in this plant are biologically active which can be used for drug development. Gardoside, 5, 6, 8-Epiloganic acid, and plantamajosides are some of the phytochemicals extracted (Figure 13.3). Plantamajoside is known for its anti-inflammatory activity and antioxidant effect by radical scavenging (Reddy et al., 2018).Phytochemicals and carbohydrates of Plantago ovata: A) Aucubin(CID-91458); B) D-xylose (CID-135191); C) L-arabinose (CID-439195); D)Rhamnose (CID 25310); E) D-galacturonic acid (CID 439215); G) Gardoside(CID-46173850); H) 5,6,8-Epiloganic Acid (CID-158144); I) Plantamajoside (CID-5281788) (ICAR-Directorate of Medicinal & Aromatic Plants Research, Anand, Gujarat, n.d.; PubChem. n.d.).
Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
Plantago ovata is very beneficial for the patients suffering from hemorrhoids by reducing the bleeding, improving the symptoms, and reducing the hemorrhoidal cushions. This bulking laxative is a stool softener that has therapeutic use for posthemorrhoidectomy complications. P. ovata contains a large amount of short-chain fatty acids as well as soluble nonstarch polysaccharides. These polysaccharides, under anaerobic fermentation, produce propionate, butyrate, and acetate components in the intestines which play a critical role in reducing the inflammation of the anorectal region.
Stress memory in two generations of Plantago major from radioactive and chemical contaminated areas after the cessation of exposure
Published in International Journal of Radiation Biology, 2023
Nadezhda S. Shimalina, Vera N. Pozolotina, Natalya A. Orekhova
Greater plantain (Plantago major L.) is a perennial herbaceous polycarpic plant of the family Plantaginaceae Juss. The generation time for this plant species is July–August. The species is diploid (2n = 12), wind pollinated, and characterized by a high level of self-pollination and high seed productivity (van Dijk and van Delden 1981). These features make P. major a convenient species for transgenerational research. It reproduces mainly by seeds, the spread of which is involuntarily promoted by humans (anthropochoria) (Zhukova 1997). The seeds can be transported over considerable distances on shoes, clothes, and on the wheels of cars. P. major is well studied for its genetic and biochemical characteristics since it is used as a medicinal plant (van Dijk and van Delden 1981; Samuelsen 2000; Squirrell and Wolff 2001).
Plantamajoside inhibits hypoxia-induced migration and invasion of human cervical cancer cells through the NF-κB and PI3K/akt pathways
Published in Journal of Receptors and Signal Transduction, 2021
Plantamajoside (PMS) is a major compound of Plantago asiatica and possesses various activities, such as anti-inflammatory, cardioprotective, and anti-fibrotic effects. PMS attenuates LPS-stimulated inflammatory response in human gingival fibroblasts by inhibiting PI3K/Akt signaling pathway [7]. PMS attenuates isoproterenol (ISO)-induced cardiac hypertrophy by inhibition of the HDAC2 and Akt/GSK-3β signaling pathway [8]. Wang et al. [9] reported that PMS exerts anti-fibrotic effect in the liver by inhibiting hepatic stellate cell activation and survival. Recently, it has been observed that PMS exerts anti-tumor activity in several types of cancers, including hepatocellular carcinoma (HCC) [10], breast cancer [11] and esophageal squamous cell carcinoma (ESCC) [12]. However, the effect of PMS on cervical cancer has not been investigated before.
Plantamajoside inhibits high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in rat glomerular mesangial cells through the inactivation of Akt/NF-κB pathway
Published in Journal of Receptors and Signal Transduction, 2021
Dongmei Xiao, Rui Yang, Li Gong, Yawei Zhang, Yongli Xie, Shenjue Ni
Plantamajoside (PMS), a phenylpropanoid glycoside isolated from Plantago asiatica, has been found to possess anti-diabetic, anti-inflammatory, and anti-oxidative activities. PMS inhibits LPS-induced MUC5AC expression and inflammation in human airway epithelial cells [18]. PMS decreases the production of inflammatory mediators and cytokines such as PGE2, NO, IL-6, and IL-8 in LPS-stimulated human gingival fibroblasts [19]. PMS significantly decreases the cadmium (Cd)-induced ROS generation and lipid peroxidation and enhances antioxidant enzyme activities in the NRK-52E cells, and improves histochemical appearances in rats, indicating that PMS has protective activity against Cd-induced renal injury [20]. Treatment of the HaCaT cells with ultraviolet B (UVB) and glycer-AGEs increase ROS level and proinflammatory cytokines expression, which are attenuated by PMS [21]. Choi et al. [22] reported that PMS exhibits antiglycation activity and antioxidant activity in vitro. However, the effect of PMS on DN remains unknown.