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Therapeutic Efficacy of Black Pepper in Gastrointestinal Disorders
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Piperine is a piperidine alkaloid with a pungent flavor and it has been studied in rats or mice in association with stomach mucosal harm induced by pressure, indomethacin, ethanol or pylorus ligature. This material shielded the stomach from ulceration by reducing the quantity of intravenous and oral gastric juice, acidity and pepsin-A function with respective dosage of 1.5 and 25 mg/kg, respectively.18
Phytoextracts and Their Derivatives Affecting Neurotransmission Relevant to Alzheimer’s Disease
Published in Akula Ramakrishna, Victoria V. Roshchina, Neurotransmitters in Plants, 2018
Piperidine alkaloids: Juliflorine:Juliflorine [Figure 21.3 (xv)] has been isolated from the leaves of Prosopis juliflora (Family: Papilionaceae) and it noncompetitively inhibits both AChE (IC50 = 0.42 μM) and BChE (IC50 = 0.12 μM) (Choudhary et al., 2005).
Phytotherapeutic Agents in Epilepsy
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Piperine is a piperidine alkaloid responsible for the pungency of black pepper (P. nigrum; Fam. Piperaceae) used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy in traditional system of medicine. In traditional Chinese medicine, a mixture of radish and pepper is used to treat epilepsy. Earlier studies have documented anticonvulsant effects of piperine against kainate-induced seizures.143 Piperine significantly delays the onset of PTZ-and PIC-induced seizures,144 seizures induced by PIL145 and STR.146 The studies indicate that piperine exhibits analgesic and anticonvulsant effects via opioid and GABA-ergic pathways, respectively.144,145 A recent study on anticonvulsant mechanisms of piperine has suggested that Na+ channel antagonist activity could also be a contributor to the complex anticonvulsant mechanisms of piperine.146
Research progress of natural products and their derivatives against Alzheimer’s disease
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Jin-Ying Liu, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Hong Cui, Xiaoting Li
Piperine is a piperidine alkaloid with a relatively simple structure and one of the main physiologically active components of piperine and longan. Piperine is currently used clinically as a spectral anticonvulsant. In addition, Masoomeh et al. showed that long-term treatment with piperine reduced oxidative damage of rats intracerebroventricularly (ICV) injected with STZ82. Furthermore, it reduced the synaptic toxicity of STZ in the hippocampus, thereby exerting a neuroprotective effect. Suresh et al. showed that intraperitoneal injection of piperine in diabetic rats not only improved memory in diabetic rats, but also reduce AD-related BACE1, PSEN1, APAF1, CASPASE3, and CATALASE gene expression83. Hsieh et al. also found that piperine protects hippocampal neurons by upregulating protein kinase B (Akt) and glycogen synthase kinase 3β (GSK-3β) signalling pathways in the hippocampus and reducing kainate (KA)- induced excitotoxicity84. Studies have also shown that piperine can inhibit the pathological changes in AD in multiple ways and can be used as a potential anti-AD drug (Figure 13).
Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid
Published in Drug Development and Industrial Pharmacy, 2023
Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang
Natural products have potential pharmaceutical/therapeutic applications owing to their various pharmacological activities. Piperine (PIP) is a natural piperidine alkaloid (Figure 1(a)) that is mainly isolated from the Piper nigrum L. and Piper longum L. plants. It is reported that PIP has multiple pharmacological activities including antioxidant [1], anti-inflammatory [2,3], antimicrobial, antibacterial, hepatoprotective [4], and cardioprotective effects. The therapeutic effects of PIP have been confirmed in highly prevalent diseases worldwide, including cancer [1,5], diabetes [6], and obesity [7]. Recent studies have also shown that PIP is widely effective in treating cancers, such as breast cancer [8], colorectal [9], and ovarian tumors [10], through a variety of ways to exert anti-tumor effects [5,11,12]. Moreover, PIP can increase the efficacy of other drugs by inhibiting metabolic enzyme activities including those associated with cytochrome P450 3A [13]. PIP improves cognitive ability as well, which has good prospects for the treatment of Alzheimer’s disease [14]. Owing to its natural properties and various pharmacological effects, PIP has huge potential applications in disease treatment; however, its poor solubility in aqueous media (slightly soluble in water: 0.04 g/L at 18 °C [15]) and the low oral bioavailability hinder its use.
Antimicrobial activity of flavonoids glycosides and pyrrolizidine alkaloids from propolis of Scaptotrigona aff. postica
Published in Toxin Reviews, 2023
T. M. Cantero, P. I. Silva Junior, G. Negri, R. M. Nascimento, R. Z. Mendonça
Piperidine alkaloids together flavones-C-glycosides were detected in geopropolis from Scaptotrigona bipunctata, while terpenoids and flavonoids were detected in geopropolis from Melipona quadrifasciata, both collected in the same locality, Florianópolis, Santa Catarina, Brazil (Cisilotto et al. 2018). In stingless bee propolis or geopropolis were found phenolic acids, hydrolyzable (Dutra et al. 2014, Torres et al. 2018, de Sousa-Fontoura et al. 2020), pentacyclic tannins triterpenes and cycloartane-type triterpenes (Pujirahayu et al. 2019, Yam-Puc et al. 2019), diterpenic acids (Sawaya et al. 2009, Carneiro et al. 2016), alkylphenols (Negri et al. 2019), fatty acids, galloyl hexoses, ellagic acid, acyl‐galloyl hexosides (de Souza et al. 2018, de Sousa-Fontoura et al. 2020), flavonoids (Cisilotto et al. 2018, Torres et al. 2018, de Sousa-Fontoura et al. 2020), steroids and saponins (Ibrahim et al. 2016), catechins and epicatechin (Hochhein et al. 2019), glycosylated phenolic acids and terpenoids (Dos Santos et al. 2017a, 2017b).