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The Human Nail: Structure, Properties, Therapy and Grooming
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Kenneth A. Walters, Majella E. Lane
The same group (Hui et al., 2007b) compared the ungual penetration of panthenol in a non-lacquer film forming nail formulation (ethanol, acrylates co-polymer, phytantriol) with an aqueous solution formulation. The nail treatment formulation showed better effectiveness on enhancement of transungual panthenol delivery into/through the deeper layers of the human nail plate than the aqueous solution of panthenol.
Liquid Crystals as Drug Delivery Systems for Skin Applications
Published in Andreia Ascenso, Sandra Simões, Helena Ribeiro, Carrier-Mediated Dermal Delivery, 2017
Lyotropic liquid crystalline systems can be formed by several amphiphilic lipids, such as monoglycerides, phospholipids, and glycolipids, which can spontaneously self-assemble in water to form liquid crystals. Some examples of materials commonly used to form liquid crystals are glyceryl monooleate (GMO), glyceryl monolinoleate (GML), glyceryl monooleyil ether (GME), phytantriol (PT), oleyl glycerate (OG), phytanyl glycerate (PG), monolinolein, monoelaidin, phosphatidylethanolamine, oleoylethanolamide, phospholipids, vitamin E TPGS, PEGylated phospholipids, alkyl glycerates and glycolipids. GMO, OG, and PT are the most widely studied lipids that form liquid crystals for drug delivery purposes [2,7,8,12,15,18,19].
Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies
Published in Drug Delivery, 2022
Rofida Albash, Rania Moataz El-Dahmy, Mohammed I. A. Hamed, Khaled M. Darwish, Abdulrahman M. Alahdal, Amira B. Kassem, Abdurrahman M. Fahmy
Hyaluronic acid-enriched cerosomes (HAECs) are regarded as a new type of vesicle that has shown great success in topical drug delivery. A previous study confirmed the potency of topical delivery of spironolactone using HAECs (Albash et al., 2021a). Both hyaluronic acid (HA) and ceramide are added to nanovesicles to augment the skin deposition of drugs (Albash et al., 2021a; 2021b). In a view of this, we represent the preparation, and characterization of cationic ceramide/phospholipid composite (CCPCs) for the management of alopecia. In addition, phytantriol is utilized in this investigation to augment skin penetration of LVC. Phytantriol is a lipid commonly employed in cosmetic manufacturing for hair and skin maintenance and is thought to improve skin penetration (Bender et al., 2005). Moreover, Dimethyldidodecylammonium bromide (DDAB) being a cationic surfactant was utilized to fabricate CCPCs that might be able to enhance skin deposition and retention of the prepared vesicles as previously reported in the literature (Oh et al., 2011). The electrostatic interaction through the negative epidermis layer and the cationic vesicles, which is thought to promote transdermal absorption, was possibly responsible for the retention in deep epidermal regions (Lin et al., 2018).
Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment
Published in Drug Delivery, 2021
Khaled M. Hosny, Waleed Y. Rizg, Hala M. Alkhalidi, Walaa A. Abualsunun, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Adel F. Alghaith, Sultan Alshehri, Amani M. El Sisi
In summary, an I-optimal design was employed to optimize NT-Cub formulation for in situ gel for ophthalmic delivery. The quantities of phytantriol, PolyMulse, and NT were taken as the independent factors, while particle size, EE%, and inhibition zone were evaluated as responses. All the independent factors were found to significantly influence these responses. The optimized NT-Cub formulation was found to contain 800 mg phytantriol, 510 mg PolyMulse, and 460 mg NT. Subsequently, the optimized NT-Cub formulation was converted into an in situ gel system using 1.5% Carbopol 934 dispersion in pH 5.5 buffer (F1) then further evaluated. The viscosity of the formulation was significantly increased when pH was increased to 7.4. The in vitro NT release from the F1 and F2 formulations was similar after 4 h and significantly higher than that from F3 and NT suspension. The ex vivo permeation studies confirmed higher drug permeation from cubosomes, and the flux of corneal permeation of NT followed the order F1 > F2 > NT suspension > commercial NT (2%) suspension. Further, the in vivo ocular irritation test indicates that the cubosome formulations produce less ocular irritation than a commercial formulation. Overall, the findings of the study confirm that the F1 formulation can reduce ocular irritancy, enhance corneal permeation, and prolong the residence time of NT.
Preparation and evaluation of phytantriol liquid crystal as a liquid embolic agent
Published in Pharmaceutical Development and Technology, 2020
Phytantriol (PYT) (Akbar et al. 2017) is an amphiphilic molecule with hydrophilic hydroxyl groups and a hydrophobic carbon chain. When PYT is dispersed in a small volume of water, a magnetic isotropic solution with extremely low viscosity is formed. The advantages of this ‘precursor solution’ are its fluidity and easy injectability. However, when PYT is dispersed in a large volume of water or other organic solvents, an extremely high viscosity liquid crystal gel can be formed, which is nontoxic and biocompatible. Compared with traditional embolic agents such as Ethiodol, Gelfoam® powder, and polyvinyl alcohol (PVA), PYT can avoid problems of poor fluidity, difficulty in embolizing the ends of blood vessels, and poor drug loading. Based on these advantages, PYT appears to be an excellent embolic agent and it has been reported that PYT can be used as an embolic material for anticancer drugs such as 10-hydroxycamptothecin (HCPT) and paclitaxel (Han et al. 2010; Qin et al. 2014).