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Transfer of facilities to the Infirmary of the Royal Hospital, Greenwich in 1870
Published in Gordon C Cook, Disease in the Merchant Navy, 2019
In September, the Lancet however carried the following notice: The ‘Dreadnought’ Committee of the MAB] have arranged to close the vessel finally for the reception of small-pox convalescents on the 14th prox.’ During the five month period, ‘1021 cases had been] taken on board and] three deaths only had] occurred’. It is the … intention of the Board the writer continued] to keep the Dreadnought for any epidemic emergency that may arise’. A later issue of the Lancet considered that an advertisement for the ‘sale by the Hackney Vestry] of the temporary hospital for small-pox was very ill-timed’; the writer had in mind the possibility of another cholera epidemic – for which isolation facilities would be urgently required. He was also conscious of difficulties involved in disinfection of the ship from small-pox.104
Visualization of Benefit–Risk Assessment in Medical Products with Real Examples
Published in Qi Jiang, Weili He, Benefit-Risk Assessment Methods in Medical Product Development, 2017
Shihua Wen, Weili He, Scott Evans, Haijun Ma, Christy Chuang-Stein, Qi Jiang, Xuefeng Li, George Quartey, Arani B. Ramin
For the example of low-dose unfractionated heparin versus enoxaparin for the prophylaxis of venous thromboembolism after major trauma (Lynd and O’Brien 2004), if it can be assumed that the incremental risk and the incremental benefit of enoxaparin versus unfractionated heparin are known with certainty, then the true incremental probability of precipitating a major bleed is Pbleed = 0.031. The incremental benefit of preventing proximal and all deep vein thrombosis (DVT) is Pprox = 0.085 and Pall = 0.110, respectively; these points are plotted on the R–B plane in Figure 10.17. Considering that the line with the slope μ = 1 represents a willingness to accept up to one major bleed to avert one DVT, then enoxaparin is the appropriate treatment strategy since the slope of the lines through both (ΔB, ΔR) coordinates is less than μ = 1.
Wi-Fi-Based Proximity Social Distancing Alert to Fight Against COVID-19
Published in Ram Shringar Raw, Vishal Jain, Sanjoy Das, Meenakshi Sharma, Pandemic Detection and Analysis Through Smart Computing Technologies, 2022
Mayuri Diwakar Kulkarni, Khalid Alfatmi
Proximity measuring technologies: Wi-Fi infrastructure will track the location of the devices so that based on this, the proximity can be calculated.Bluetooth tracking infrastructure is also helpful to measure prox-from the location of connected devices.Wearable devices or smartphone apps can estimate the distance between proximity devices.AI-based proximity estimation from video streaming by analyzing the videos.GPS for the proximity estimation.No-touch access controls such as RFID, Wireless badges can be used. These will be identifying the people entering and leaving zones along with the count of the people in proximity.Bluetooth, GPS, Wi-Fi-based proximity measure techniques can easily be implemented because of the availability of smartphones. And these all the sensors are present in it. By considering this, different countries used different technology platforms after the lockdown phase. This lockdown phase can be said preparation time for all the countries to come up with technical solutions.
A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice
Published in Archives of Physiology and Biochemistry, 2019
To assess the localisation and expression changes of PROX-1, an immunohistochemical stain was performed. As shown in Figure 6(A-a), PROX-1 was rarely expressed in the sham group. After I/R, PROX-1 was induced in the proximal tubular, glomerular capsule epithelial, and endothelial cells. (Figure 6(A-b–h)) Quantification result shown that PROX-1 was induced from 12 h, dramatically elicited on Day 1, and then mitigated and consecutively expressed to Day 8 (Figure 6(B)). Immunofluorescence double stain with confocal analysis showed that LYVE-1-positive cells were distributed in the endothelium cells of the glomerular (green) region. PROX-1-positive cells were distributed in the nuclei of tubular, endothelial, and glomerular cells (red) in Figure 7. These results suggest that PROX-1 and LYVE-1 are colocalised in the endothelial cells of the glomerulus.
Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma
Published in OncoImmunology, 2018
Natacha Bordry, Maria A. S. Broggi, Kaat de Jonge, Karin Schaeuble, Philippe O. Gannon, Periklis G. Foukas, Esther Danenberg, Emanuela Romano, Petra Baumgaertner, Manuel Fankhauser, Noémie Wald, Laurène Cagnon, Samia Abed-Maillard, Hélène Maby-El Hajjami, Timothy Murray, Kalliopi Ioannidou, Igor Letovanec, Pu Yan, Olivier Michielin, Maurice Matter, Melody A. Swartz, Daniel E. Speiser
To define the localization of LECs in different human tissue sections we performed IHC using Prox-1 and podoplanin antibodies. Histological analysis confirmed that podoplanin was specifically expressed on lymphatic vessels in different zones of the primary tumor (Fig. 1A), the tumor region of metastatic LNs (Fig. 1B) and the normal skin (Fig. S1A). In contrast, Prox-1 antibody was not well suited as LEC marker within these tissues, as certain tumor cells as well as skin epithelial cells may also be positive (Fig. 1A and B and Fig. S1A and B).