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Medicinal Plants Against COVID-19
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Binish Khaliq, Naila Ali, Ahmed Akrem, M. Yasin Ashraf, Arif Malik, Arifa Tahir, M. Zia-Ul-Haq
Crocin compound was isolated from C. sativus and have the remarkably antiviral activity. Crocin inhibit the replication of human coronavirus and reduced the symptoms of the disease in the infected people. C. sativus is medicinal herbs and is being used to treat the HIV and human coronavirus [99]. Nerium oleander is also herbal medicinal plants that have 11.25% digitoxigenin compound and its derivatives. These compounds and their derivatives have the anticancer and antiviral activity [100]. Lauris nobilis herbal plants contain the ß Eudesmol compounds in low quantity, i.e., 2.39%, but this compound has a very good potential to interact with the target and showed the antibacterial antiviral activity against the different bacterial and viral diseases [101]. Docking results of these three compounds with the Coronavirus main proteases inhibited the binding site of Coronavirus main protease and controlled the replication of Coronavirus main protease [102].
Anti-Inflammatory Properties of Bioactive Compounds from Medicinal Plants
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Muhammad Imran, Abdur Rauf, Anees Ahmed Khalil, Saud Bawazeer, Seema Patel, Zafar Ali Shah
Natural extracts of Aloe barbadensis (@0.5%, 1%, and 2%) administrated in diet for a period of fifteen days resulted in noteworthy elevation of macrophages contents that are accountable for phagocytic action in tissues [10]. Aloe vera-based Nerium oleander extracts increased antioxidative protection, protected cell viability, and intracellular reduced glutathione and significantly decreased the formation of ROS [80]. Similarly in propagation of RAW 264.7 cells, Aloe-emodin markedly inhibited IL-6, NO, and IL-1β formation, without any cytotoxicity. Expression levels of mRNA for IL-6, iNOS, and IL-1β genes were retarded by administration of Aloe-emodin. Analysis of Western blotting revealed suppressing behavior of aloe-emodin against LPS-activated expression of iNOS protein, degradation of IκBα and JNK, p38, ERK, and Akt phosphorylation [29].
A comprehensive review of cardiotoxic effects of selected plants
Published in Toxin Reviews, 2021
Akbar Anaeigoudari, Nahid Azdaki, Mohammad Reza Khazdair
Nerium oleander is an ornamental shrub that is frequently grown as an attractive plant in gardens and public city areas. The flowers of N. oleander are fragrant, funnel-shaped, with white to pink to deep red colors (Figure 3). This plant has been distributed in the subtropical Asia, and Mediterranean region. Recently it is grown in USA, Australia, China, and Middle East countries (Derwich et al.2010). The potential toxic effects of all parts of the plant on animal and human body were reported (Farkhondeh et al.2020). The main constituents isolated from leave extract of N. oleander are, Octadecane, 3-ethyl-5–(2-ethylbutyl), Monolinoleoylglycerol trimethylsilyl ether, Eicosene and Cyclohexen-1-one (Hameed et al.2015). In addition, the seeds of plant contain glucosides including; oleandrine, odorosides, adigoside), and the bark of N. oleander also contains glucosides including; rosaginoside, nerioside, corteneroside (Zibbu and Batra 2010).
Toxic thrombocytopenia during Nerium oleander poisoning
Published in Clinical Toxicology, 2018
Camille Bataille, Lise Capaldo, Arnaud Courtois, Benjamin Seguy, Clémence Lotiron, Magali Labadie
Nerium oleander (apocynaceae) is an evergreen shrub that contains cardiac glycosides, mainly oleandrin, that exhibits cardiac toxicity similar to the one induced by digitalis glycosides [1]. We reported the case of a 33 years old woman, who ingested an infusion of 20 Nerium oleander leaves (approximately 25 g in 350 mL boiling water, for 20 minutes). Seven hours after drinking the infusion, she developed a headache and several episodes of vomiting. Blood pressure was normal (110/60 mmHg), but there was a profound sinus bradycardia (25 beats per minutes) without other cardiac abnormality. Her laboratory evaluation, 16 hours post ingestion, demonstrated hyperkalemia (6.2 mmol/L) with a normal serum creatinine (82 µmol/L). Upon arrival, she was treated by a transvenous pacer and was administered fondaparinux, 0.5 mg, atropine, 10 mg, metoclopramide, 10 mg, and digoxin immune Fab, 160 mg. Four hours after the dose of digoxin immune Fab, she was treated by temporary transcutaneous right ventricular pacing and a second administration of digoxin immune Fab in addition to a dose of activated charcoal, 50 g. Five days post ingestion she was clinically asymptomatic, but still experiencing bradycardic episodes. Serum oleandrin concentrations were of 19.6 and 7.5 μg/L, 15.5 and 44 hours after ingestion respectively. Approximately 72 hours after the Nerium oleander ingestion and 34 hours after fondaparinux administration, she developed an episode of thrombocytopenia (76 109/L). The platelet count returned to normal 5 days later, without clinical bleeding. Finally, she became asymptomatic and totally recovered within 8 days.
Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
Published in International Journal of Neuroscience, 2020
İsmail Ünal, Esin Çalışkan-Ak, Ünsal V. Üstündağ, Perihan S. Ateş, Ahmet A. Alturfan, Meric A. Altinoz, Ilhan Elmaci, Ebru Emekli-Alturfan
In order to prevent mitochondrial damage, antioxidants targeting mitochondria have come to the fore in recent years. Mitoquinone, the most interesting antioxidant for mitochondria, is located in the mitochondria and has been reported to be highly effective in protecting against mitochondrial oxidative damage [8]. In recent years, it has been suggested that oleandrin which is the active ingredient of Nerium oleander has neuroprotective activity [9,10].