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Drug-induced erythroderma
Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019
Causality assessment determines the causal relation between the drug administered and the occurrence of an adverse event. Various algorithms used in decisions on causality of ADRs are Jones algorithm, Naranjo algorithm, Yale algorithm, Karch algorithm, Begaud algorithm, Australian Adverse Drug Reactions Advisory Committee and the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria [51]. These algorithms reduce the variation in the evaluation of ADRs. However, none of these algorithms are gold standard [51–53].
COVID-19 Vaccination and Uveitis: Epidemiology, Clinical Features and Visual Prognosis
Published in Ocular Immunology and Inflammation, 2022
Nawfel Ferrand, Massimo Accorinti, Mamta Agarwal, Christoph Spartalis, Priscilla Manni, Nicole Stuebiger, Manfred Zierhut
To associate a particular adverse event to the administration of a drug or vaccine, it is important to consider a temporal relationship between the intake/inoculation and the onset of the adverse reaction. This time is variable, but generally fewer than 30 days is considered credible. In our patients, the mean time from vaccination to uveitis onset was 10.7 days (median: 12 days), without any significant difference between patients who presented a relapse of their uveitis and those who were diagnosed with new-onset uveitis (9.9 versus 13.2 days, p = .35). To better define the relationship between the vaccination and uveitis onset, we applied the Naranjo algorithm to all our patients.27 This has been suggested as “possible” or “probable” the association of the COVID-19 vaccination with uveitis in our patient population. All our patients who presented new uveitis after vaccination showed a probable association with the COVID vaccination (p < .01), thus suggesting a closer relationship between the vaccination and the new onset of uveitis.
Atypical antipsychotics in the treatment of patients with a dual diagnosis of schizophrenia spectrum disorders and substance use disorders: the results of a randomized comparative study
Published in Journal of Addictive Diseases, 2021
V. Yu. Skryabin, M. A. Vinnikova, E. V. Ezhkova, M. S. Titkov, R. A. Bulatova
Drug safety was assessed by the development of adverse events (AEs), serious adverse events (SAEs), or adverse drug reactions (ADRs) in patients, taking their symptoms, frequency, and severity into account. The Naranjo algorithm (The Naranjo algorithm is one of the most widely utilized causality assessment tools. This assessment is comprised of 10 questions concerning the implicated medication and reaction phenotype. Each answered question has an individual score, which is then totaled to provide a final score that is associated with one of four categories of likelihood that the drug was associated with the reaction (unlikely, possibly, probably, or definitely)) was used for determining the likelihood of whether an adverse reaction was actually due to the drug rather than the result of other factors.
An inter-professional student-run medication review programme. Reducing adverse drug reactions in a memory outpatient clinic: a controlled clinical trial
Published in Expert Opinion on Drug Safety, 2022
Michael O. Reumerman, Milan C. Richir, Rowan Sultan, Hester E.M. Daelmans, Hans Springer, Els Grijmans, Majon Muller, Michiel A. van Agtmael, Jelle Tichelaar
During the ADR interview, the previously detected ADRs, current medication list and medication changes since the patient visit were available for the clinical pharmacologist. Patients were first asked to report any new health problem or change in their condition since their outpatient visit. If they reported a health problem, they were asked to describe the severity of each new problem and indicate when it started in relation to the initiation of drug treatment, in order to classify the symptoms according to the WHO causality assessment scale and Naranjo algorithm. The nature, severity [29], avoidability (by Hallas et al. [27]) and preventability (on the Schumock and Thornton scale [28]) of the ADRs reported at first consultation were also reevaluated.