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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Naftifine is a synthetic allylamine derivate with broad-spectrum antifungal activity. It can be fungicidal or fungistatic depending on the concentration and the organisms involved. Naftifine is indicated for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum. Naftifine is also effective against gram-negative and gram-products, positive bacteria and has anti-inflammatory activity by targeting the prostaglandin pathway. In pharmaceutical naftifine is employed as naftifine hydrochloride (CAS number 65473-14-5, EC number not available, molecular formula C21H22ClN) (1).
Antifungals
Published in Rajendra Prasad, Mahmoud A. Ghannoum, Lipids of Pathogenic Fungi, 2017
A. S. Ibrahim, R. Prasad, M. A. Ghannoum
Allylamines represent an entirely new class of antifungal agents. Naftifine is one of those allylamines that have been developed to the point of clinical usage with other related compounds reaching various preclinical stages of development. Allylamines were shown to be highly effective against dermatophytes but less effective against C. albicans.5,59
Naftifine
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
In addition to its antifungal activity, naftifine exhibits anti-inflammatory properties (Evans et al., 1993). In one study, topical application of naftifine was equivalent to clotrimazole with 1% hydrocortisone with respect to clinical resolution of symptoms and to mycologic efficacy in patients with confirmed dermatomycosis (Evans et al., 1993). Characterization of naftifine anti-inflammatory activity showed that it inhibits chemotaxis and respiratory burst activity in polymorphonuclear leukocytes and decreases adherence of these cells to endothelial monolayers (Solomon et al., 1993; Choi et al., 1996). Naftifine can also attenuate the expected erythema response when applied after UV irradiation (Rosen et al., 1997). More recently, naftifine has been shown to significantly reduce cell viability in lymphoma and multiple myeloma cell lines in vitro. This toxicity is due to the chemical similarity to known Wnt (Wingless-related integration site) inhibitors, which show promise as targeted therapies for cancers caused by aberrant activation of Wnt/beta-catenin signaling (Schmeel et al., 2015).
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea
Published in Drug Delivery, 2021
Adel F. Alghaith, Sultan Alshehri, Nabil A. Alhakamy, Khaled M. Hosny
Naftifine, a primary topical antimycotic drug with allylamine structure, is active against a broad spectrum of dermatophytes belonging to Trichophyton and Microsporum spp. and has shown good activity against Candida and Aspergillus spp. (Cuenca-Estrella et al., 2006). It is believed to exert a fungicidal effect through squalene epoxidase inhibition in fungi, thus diminishing ergosterol biosynthesis (Monk & Brogden, 1991). In contrast to other antifungal drugs like azoles, naftifine is highly selective to ergosterol biosynthesis and does not affect drug metabolism in the liver even if a significant portion reaches the systemic circulation (Lee et al., 2007). Although naftifine is well tolerated, it was reported to cause some mild inflammations and stinging sensation, which might affect patient compliance (Altmeyer et al., 1990).
Majocchi granuloma presenting as a verrucous nodule of the lip
Published in Baylor University Medical Center Proceedings, 2018
Ritu Swali, Elmira Ramos-Rojas, Stephen Tyring
An otherwise healthy 41-year-old white man presented with a 1-year history of a nodular lesion on the right corner of his mouth without pruritus, pain, or history of trauma to the area. The patient reported a 10-pack-year smoking history and frequent sun exposure without the use of sunscreen, but denied any history of skin cancer. The patient self-treated the lesion using over-the-counter topical antibiotics, without improvement. Topical or systemic corticosteroids were not attempted. On clinical examination, a 9 × 6 mm verrucous, erythematous nodule was observed on the right labial commissure (Figure 1). The lesion was crusted and without ulceration. A shave biopsy was performed to rule out squamous cell carcinoma. On hematoxylin and eosin staining, there was pseudoepitheliomatous hyperplasia with acute neutrophilic inflammation within the invaginated stratum corneum (Figure 2a). Periodic acid-Schiff staining revealed lesional cells positive for hyphae in cornified elements of follicles (Figure 2b). The clinical and histopathologic findings confirmed the diagnosis of Majocchi granuloma. Accordingly, the patient was managed with naftifine gel, 1% topically applied twice a day to the lip, and terbinafine, 250 mg taken orally once a day for 30 days. Two months later, complete resolution was documented.
Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective
Published in Expert Opinion on Drug Delivery, 2019
Riya Bangia, Gajanand Sharma, Sunil Dogra, Om Prakash Katare
Naftifine has shown activity against dermatophytes and is used as a fungicidal topically. Moreover, it targets prostaglandin pathway and shows anti-inflammatory activity [33]. Its efficacy is similar to that of terbinafine and azoles [31]. Two percent naftifine gel has been found to be effective against moccasin-type tinea pedis [34–36]. For the therapy of interdigital tinea pedis, tinea corporis and tinea cruris caused by the organism T. rubrum in individuals aged more than 18 years, FDA has approved naftifine 2% cream and gel for once daily application for 14 days and use of both the formulations has shown acceptable cure rates after application for 2–8 weeks [33].