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Moringa oleifera (Drumstick)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
The genus of Moringa consists of several species: Moringa concanensis, Moringa arborea, Moringa longituba, Moringa stenopetala, Moringa pygmaea, Moringa oleifera, Moringa borziana, Moringa ruspoliana, Moringa hildebrandtii, Moringa rivae, Moringa drouhardii, Moringa ovalifolia and Moringa peregrina (Abd Rani et al., 2018). Among all of the species, Moringa oleifera is one of the most researched and consumed for its pharmacological, nutritional and phytochemical properties. In accordance with Ayurveda, it has featured properties for the management of a number of ailments, such as dermatological disorders, fevers, epilepsy, haemorrhoids, ophthalmic disorders and asthma. As a matter of fact, it is a therapeutic plant traditionally identified in regard to malnutrition and other ailments (Milla et al., 2021).
Potential Significance of Proteases
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Marwa Waheed, Muhammad Bilal Hussain, Sadia Hassan, Mohammad Ali Shariati, Oluwafemi Adeleke Ojo
Globally, Moringa oleifera can be used for food and has some advantageous properties. It is a rich source of nutrients, amino acids, antioxidants, and also has anticancer and antiinflammatory properties.77 Moringa could be an enormously important source of food, as it is an extremely good source of sulfur containing amino acids like cystine and methionine, minerals (particularly iron), and vitamins A, B, and C. It can be used in instant noodles, spices, bread, fortifying sauces, juices, and milk.54
Protecting Pancreatic β-cells from Metabolic Insults
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Methanol extract of leaves of Moringa oleifera Lam. given orally to alloxan-induced diabetic rats (blood glucose ≥ 250 mg/dL) at a dose of 600 mg/kg for 6 weeks (metformin: 100 mg/kg) had no effect on food intake, and prevented weight loss.90 This supplementation improved glucose tolerance in diabetic rodents as efficiently as metformin given orally at a daily dose of 100 mg/kg/day.90 The extract lowered glycemia from about 275 to 125 mg/dL (normal about 100 mg/dL; metformin at 100 mg/kg/day: about 125 mg/dL) and increased insulinemia close to normal.90 The extract normal cholesterol and low-density lipoprotein, lowered triglycerides, and brought high-density lipoprotein above normal values.90 In liver and skeletal muscles of treated rodents, the extract increased glycogen synthetase activity and glycogen contents close to normal.90 Gastrocnemius muscle preparations from rats treated this the extract had increased glucose uptake capacity compared with muscle preparations from untreated diabetic group.90 All of these plants with activity on sterptozotocin or alloxan may be simply anti-inflammatory to suspect antioxidant. One could draw the inference that principles and/or metabolites of this tree protect β-cells against oxidative insults in human but the appreciation of pancreatic recovery in streptozotocin or alloxan induced diabetic in rodents requires careful consideration. Wild-type rats or mice do not develop type 2 diabetes and have a β-cells replication rate of about 2.5%, whereas in human it is only around 0.2%.91 Thus, regeneration of damaged β-cell and islets neoformation seems to take place via mitosis of endocrine islet cells and cell proliferation from tubular structures.92,93Moringa oleifera Lam. is consumed almost daily in the Island of Cebu where type 2 diabetes incidence seems comparatively low to other Southeast Asian countries. Clinical trials to assess the beneficial effect of Moringa oleifera Lam. consumption in metabolic syndrome is warranted.
Targeting Bone Metastases Signaling Pathway Using Moringa oleifera Seed Nutri-miRs: A Cross Kingdom Approach
Published in Nutrition and Cancer, 2022
Kinjal Bhadresha, Maulikkumar Patel, Jpan Brahmbhatt, Nayan Jain, Rakesh Rawal
Plants have provided a notable base of nutraceuticals, which are used by nearly two-thirds of the world’s population for health advantages and avoidance of diseases. Furthermore, recently a large number of herbs have been developed for their anticancer properties (1, 2). Moringa oleifera belonging to the family of Moringaceae is an effective most useful nutritional and medicinal plant. Moreover, M. oleifera is rich in nutritional value remaining in the presence of a variety of essential phytochemicals present in several organs, such as leaves, pods, and seeds which are edible and are used in numerous countries (including the various regions of Africa) for their high relating nutritional value (3). Almost all tissue from the Moringa plant can be used as a traditional medicine for the treatment of a variety of diseases, such as respiratory distress, skin diseases, ear and dental infections, diabetes, hypertension, anemia, and cancer (4, 5). Additionally, the pharmacological and nutritional values of the seed and leaves extract containing bioactive compounds like antioxidants, vitamins A, B, and C, minerals, proteins, and essential amino acids are well described by Leone et al (2015) (6). A recent study described the effect of In Vitro simulation digestion on the biological activity of M. oleifera against bone metastases from prostate cancer (7).
Aqueous Extract of Moringa oleifera Exhibit Potential Anticancer Activity and can be Used as a Possible Cancer Therapeutic Agent: A Study Involving In Vitro and In Vivo Approach
Published in Journal of the American College of Nutrition, 2021
Dharmeswar Barhoi, Puja Upadhaya, Sweety Nath Barbhuiya, Anirudha Giri, Sarbani Giri
The efficacy of plants toward cancer treatment is attributed to the bioactive compounds present in plants. Scientific reports indicate that bioactive compounds have immense potential to block or suppress cancer (7). Moringa oleifera (MO) is one of the most cultivated angiospermic plants belonging to the family Moringaceae. The plant has nutritional values as it contains high amount of proteins, vitamins and minerals. Different parts of Moringa oleifera have been traditionally used by Indians and Africans in the treatment of more than 300 ailments including cancer (8). The plant possess various bioactive compounds like flavonoids, phenolics, vitamin C (ascorbic acid), α-tocopherol, β-carotenoids, etc. (9–13). The antioxidant, antidiabetic or anti-inflammatory potential of Moringa oleifera can be attributed to the bioactive compounds present in it (14–17).
Moringa oleifera leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats
Published in Clinical and Experimental Hypertension, 2020
Direk Aekthammarat, Patchareewan Pannangpetch, Panot Tangsucharit
Epidemiologic studies support the potential of several medicinal plants to prevent and treat cardiovascular diseases with minimal side effects (6), providing an alternative source of drugs. Moringa oleifera Lam (Moringaceae) is a plant traditionally used as a nutritious food and in herbal medicine. Many kinds of medicinal products from M. oleifera leaves are available in the market nowadays and it has been claimed that some of them have antihypertensive action (7). Moringa oleifera leaves contain flavonoids, phenolic acids, glucosinolates, tannins, and triterpenes, some of which exhibit pharmacological actions in cancer, diabetes, hypercholesterolemia, insulin resistance, nonalcoholic liver disease, and overall inflammation (7). An acute-toxicity study demonstrated that the oral LD50 of M. oleifera leaf aqueous extract exceeds 6,000 mg/kg (8). Preclinical studies have shown that the mustard oil glycosides (thiocarbamates and isothiocyanates) isolated from M. oleifera leaf extract are responsible for the hypotensive activity in anesthetized normotensive rats (9,10).