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Membrane Transport
Published in Lelio G. Colombetti, Biological Transport of Radiotracers, 2020
Figure 8 applies to an asymmetrical system. For a symmetrical carrier the primed rate constants are equal to the unprimed ones. In any event, the principle of detailed balance or microscopic reversibility28 must hold for this system:
Kinetic Theory
Published in Clive R. Bagshaw, Biomolecular Kinetics, 2017
Equation 2.52 also demonstrates the principle of microscopic reversibility. At equilibrium, there is no net flux between the species, but individual molecules will convert between the states in accord with their intrinsic rate constants. If P + L forms P*L predominantly via PL as an intermediate, then it follows that P*L will predominantly dissociate to P + L via PL. If this were not true, there would be a net unidirectional flux around the cycle, which would violate the laws of thermodynamics.
Formation of Peptide Bonds — Proteases as “Activating Systems”
Published in Willi Kullmann, Enzymatic Peptide Synthesis, 1987
The enzymes catalyzing the processes in which peptide synthetic chemists are most interested are the proteases. Although commonly known for their proteolytic action, they obey, in common with all other biocatalysts, the principle of microscopic reversibility. As a consequence, proteases accelerate both the forward and the reverse reaction of the protease-specific chemical processes to the same degree. Since an enzyme changes rate but not equilibrium, the position of the latter exclusively determines whether a particular peptide bond is preferentially generated or destroyed in a given protease-catalyzed reaction.
Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Francesco Balestri, Mario Cappiello, Roberta Moschini, Umberto Mura, Antonella Del-Corso
As mentioned in the introduction, serious problems may be encountered in attempting to correlate the apparent inhibitory constants, with a physical interactive model. In fact, a different legitimate model of action, absolutely equivalent to the classic approach, is the one reported in Figure 6, in which the equilibrium generating ESI is omitted, based on the microscopic reversibility principle.