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Total Hip in a Day: Setup and Early Experiences in Outpatient Hip Surgery
Published in K. Mohan Iyer, Hip Joint in Adults: Advances and Developments, 2018
For bleeding prevention intravenous (IV) administration of 1 g tranexamic acid is administered. Additionally for pain, the patient receives 2 g of metamizole, 50 mg of dexketoprofen and 3 or 4 mg piritramide all intravenously. We also routinely administer a single shot of antibiotics (cefuroxime 1.5 g) intravenously (Table 18.1).
Acute pain and medical disorders
Published in Pamela E Macintyre, Suellen M Walker, David J Rowbotham, Clinical Pain Management, 2008
Metamizole is an effective analgesic in renal colic, particularly via the intravenous route. Limited data indicates that a single dose metamizole is of similar efficacy to other analgesics used in renal colic, although intramuscular metamizole was less effective than 75 mg of diclofenac.105[I]
Intravenous and subcutaneous patient-controlled analgesia
Published in Harald Breivik, William I Campbell, Michael K Nicholas, Clinical Pain Management, 2008
Locher Stephan, Michele Curatolo
This medication is not available in many countries, due to the risk of the side effect of agranulocytosis, although this seems to be rare.33 Data on metamizole as an adjuvant is unclear in terms of efficacy for the reduction of pain and opioid consumption.24,34,35
Post-tonsillectomy hemorrhage: cost-benefit analysis of prolonged hospitalization
Published in Acta Oto-Laryngologica, 2020
Erich Vyskocil, Wolf-Dieter Baumgartner, Matthaeus Ch. Grasl, Stephan Grasl, Christoph Arnoldner, Johannes Steyrer, Boban M. Erovic
Preoperative examinations included full blood count, clotting screen (prothrombin time, partial thromoboplastin time). Treatment was adapted to minimize bleeding risk if patients received medication which had an effect on blood coagulation due to their comorbidities. All interventions were performed under general anesthesia, using cold-steel dissection with bipolar diathermy. Adenoidectomy was performed with adenotoms. Patients were hospitalized for three nights. One week after surgery a routine follow-up appointment in the outpatient clinic. Some patients required prolonged postoperative observation (e.g. pain, poor general condition, long travel time to the next emergency department, postoperative bleeding, severe nausea or pain). Pain control was accomplished by paracetamol, mefenamic acid and diclofenac in the standard dosages. Patients with severe pain, which could not be sufficiently treated with above-mentioned drugs, also received Metamizole given intravenously. In some cases of persisting pain, adults received synthetic opioid analgesic (Piritramide). Fever, vomiting and dehydration were treated symptomatically. Postoperative care also included monitoring during two surgeon rounds per day and permanent observation by the nursing staff.
Tramadol prescription patterns in patients followed by general practitioners and orthopedists in Germany in the year 2015
Published in Postgraduate Medicine, 2018
Karel Kostev, Christian Von Vultée, Diethard M. Usinger, Jens-Peter Reese
Another important result of our study was that, when tramadol was prescribed in combination with other analgesics, it was prescribed in conjunction with metamizole or paracetamol. This finding is in line with the previous literature, as these two molecules are among the most frequently prescribed pain drugs in Germany [20]. In 2015, Stammschulte et al. analyzed spontaneous reports of metamizole-associated agranulocytosis between 1990 and 2012 [28]. In this study of 161 cases, they discovered that off-label use occurred in 25% of the population and that approximately 24% of patients died. The authors further found that agranulocytosis occurred within seven days in nearly one of every three subjects and within six weeks of permanent or intermittent treatment in two of every three subjects. Based on these data, the prescription of metamizole should be carefully monitored, particularly in older patients and those with multiple chronic morbidities.
Impact of Non-Steroidal Anti-Inflammatory Drugs on Recurrence and Survival after Melanoma Surgery: A Cohort Study
Published in Cancer Investigation, 2020
Bruno Luís de Castro Araujo, Jadivan Leite de Oliveira, José Francisco Neto Rezende, Washington Silva Noguera, Andréia Cristina de Melo, Luiz Claudio Santos Thuler
Metamizole is an analgesic used in many European and South American countries. The main postulated mechanisms of action of this analgesic are COX-3 inhibition and activation of endogenous cannabinoid and opioidergic systems (35). It has a slight anti-inflammatory effect on experimental models, probably because of its weak COX-1 and -2 inhibitory effect (36). Dexamethasone is used frequently because of its antiemetic proprieties, but it has been associated with worse 5-year OS after colorectal cancer surgery (37). Cox proportional hazards model showed no association between metamizole or dexamethasone and all selected outcomes (Tables S2–S5). Furthermore, Cox regression model showed no interaction between metamizole or dexamethasone and NSAIDs (Tables S6 and S7).