Drug treatments and interactions, disease progression and quality of life in ALS patients
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022
Luca Diamanti, Elisa Bianchi, Klodjana Mucaj, Cristina Cereda, Silvio Garattini, Ettore Beghi, Elisabetta Pupillo
According to the European Federation of Neurological Societies (EFNS) (5), there is insufficient evidence to recommend treatment with vitamins, testosterone, antioxidants such as co-enzyme Q-10 and gingko biloba, intravenous immunoglobulin therapy, cyclosporin, interferons, copaxone, KDI tripeptide, neurotrophic factors (including brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1) and mecasermin rinfabate), ceftriaxone, creatine, gabapentin, minocycline, stem cells or lithium. As symptomatic treatment aims to improve health-related quality of life (HRQoL) of patients and caregivers, symptoms should be treated as they become prominent and incapacitating (5).