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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Magnolia officinalis is a species of magnolia tree native to the mountains and valleys of China. It has long been used in Traditional Chinese Medicine and is an essential component of at least two classical herbal combinations, banxia houpu and zhi‐zi‐hou‐po, that are used to treat symptoms of MDD.1 Modern studies have shown aqueous and methanolic extracts of Magnolia to exhibit antioxidative, anti-inflammatory, anti-tumorigenic, antidiabetic, anti-microbial, anti-nociceptive, anti-neurodegenerative, and antidepressant properties.2
Herbal Drug Discovery Against Inflammation: From Traditional Wisdom to Modern Therapeutics
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Shalini Dixit, Karuna Shanker, Madhumita Srivastava, Priyanka Maurya, Nupur Srivastava, Jyotshna, Dnyaneshwar U. Bawankule
The evidence to support the use of the natural product in medication came into existence in 1805 with the discovery of morphine. There are some plants described in Ayurveda as well as in Ayurvedic Pharmacopeia of India having inflammatory properties such as Curcuma officinalis (Family: Zingibera-ceae), Aralia nudicaulis (Family: Araliaceae) (Lee et al., 2011; Oh et al., 2009; Seo et al., 2007; Wang, Li, Ivanochko, and Huang, 2006; Chung et al., 2005; Park et al., 2005; Ryu et al., 1996). These are the plants extensively studied and addressed for their profound pharmacological activities and also been used as traditional medicine (TM) for the treatment of rheumatoid arthritis, ulcerative colitis, pancreatitis, cancer, and osteoarthritis, etc. Plants such as Bauhinia variegate (aerial part) found to have promising anti-inflammatory activity against the lipopolysaccharides, interferon λ induce nitric oxide (NO) and cytokines (Singh, Singh, and Singh, 2016). Glycyrrhiza glabra and Acacia arabica (Babul) used for respiratory tract infections are mentioned in Ayurveda (Aggarwal et al., 2011). The glycosidal fraction of ethanolic extract of unripe pods of Acacia farnesiana, Aegle marmelos (L.), Correa ex Roxb. (Bael) yields coumarin and marmin from the roots, The plant extract of Ageratum conyzoides of family Asteraceae, mentioned as Dochunty, Berberis aristata of family Berberidaceae commonly known as ‘Daruharidra’ is an evergreen shrub (Khare, 2008). The mucosal inflammation in the oral tract can be treated with Agrimonia eupatoria. The salicylate components of Aloe barbadensis Ghritkumaarika (Mill) or Aloe gel reported to inhibit bradykinin, a pain-producing agent. Blumea lacera called as Kukundara showed marked anti-inflammatory activity in bradykinin and carrageenin-induced inflammation in rats. Boerhavia diffusa Linn, a weed Rakta-punarnavaa found throughout India possess anti-inflammatory property for renal diseases and also possess antiarthritic activity. Ethanolic extract of M. flagellipes decreased the edema at the rate of 11.7% and 54.2% in acute inflammation and 7.00% and 42.40% for chronic inflammation at the dose of 10 and 50 mg/kg induced by carrageenan and formalin (Uchegbu et al., 2015). Magnolia kobas stem bark inhibits the pro-inflammatory mediators (IL-ß, TNFα). The M. kobas treatment suppresses TPA induced ear swelling (in-vitro/in-vivo) (Kang et al., 2008). 4-O-methylhonokiol novel compound isolated from Magnolia officinalis shows anti-inflammatory properties by inhibiting the NF-κB (Oh et al., 2009). The chloroform extract of dried fruits of Babassu mesocarp showed significant anti-inflammatory and analgesic properties (Azevedo et al., 2007). Some other plants have also been reported for having anti-inflammatory activities are given in Table 3.1.
Gold nano particles synthesized from Magnolia officinalis and anticancer activity in A549 lung cancer cells
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Yuanyuan Zheng, Jianwu Zhang, Rui Zhang, Zhuang Luo, Chu Wang, Shaoqing Shi
Numerous other factors are also connected with lung cancer development such as exposure to carcinogens such as asbestos, silica, radon, arsenic and air pollution [14,15]. Habitual utilization of conventional phytochemicals is capable of lessening the risk and enlargement of definite cancers [16]. Magnolia officinalis belongs to Magnoliaceae family and is used for many disorders like cough, body pain, nervousness, gastrointestinal disorders and sensitive allergic diseases. Root and stem of Magnolia officinalis was shown to have anti-inflammation and antioxidant properties, muscle relaxation property and effective against cardiovascular diseases [17–20]. Previous studies prove that Magnolol displays anti-cancer activity by reducing differentiation, proliferation, and restrains angiogenesis, counteracting metastasis [21–24].
Evaluation of Natural Product Compositions for Appetite Suppression
Published in Journal of Dietary Supplements, 2019
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Tae-Woo Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
Detailed procedures of composition matter preparations have been described on U.S. patent application entitled, “Compositions and Methods for Managing Weight”, with publication number 20140004215. Dried bark of Magnolia officinalis and dried root bark of Morus alba were collected from Chongqing, China, and identified by professor Shou-Yuen Zhao from Si-Chuan Chinese Traditional Medicine Research Institutes. A voucher of specimens of Magnolia officinalis (P00491) and Morus alba (P00329) was deposited at the plant library of Unigen, Seattle, WA, USA. When recollected, Magnolia officinalis barks and Morus alba root barks were always characterized and confirmed in comparison with the original voucher specimens. Dried Ilex paraguayensis leaves extracts were obtained from Naturex (NJ, USA).
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188
Published in Drug Delivery, 2020
Guoyuan Li, Yuting Lu, Yongchun Fan, Qing Ning, Weiguang Li
Magnolol, the major bioactive ingredient of Magnolia officinalis, is known to have various activities both in vitro and in vivo, including antioxidant, anti-inflammatory, anticancer, and antidepressant activities. It affects intramolecular hydrogen by hindering hydrogen abstraction from the hydroxyl group, which normally reduces ONOO− and O2 and has antioxidant effects (Chen et al., 2011; Zhao & Liu, 2011). Magnolol exerts anti-inflammatory properties by downregulating the expression of Toll-like receptor 4 (TLR4), which is upregulated by lipopolysaccharide (LPS). This effect attenuates the TLR4-mediated activation of nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling as well as the release of pro-inflammatory cytokines (Fu et al., 2013). Further, magnolol treatment has been shown to induce apoptosis, to suppress cell proliferation through cell cycle arrest and to facilitate pro-apoptotic molecules in human glioma cells (Chen et al., 2009; Liang et al., 2014; Tsai et al., 2020). Recent studies (Zhang et al., 2017a) have shown that magnolol also induces autophagy and inhibits the migration and invasion of human PC3 cells. Furthermore, magnolol enhances both phasic and tonic GABAergic neurotransmission in hippocampal dentate granule neurons, which suggests that it may be an effective anxiolytic, sedative, and anticonvulsant drug (Alexeev et al., 2012). Unfortunately, poor aqueous solubility and absorption are two major limiting factors in the clinical use of magnolol (Tsai et al., 2016; Lee et al., 2017). Therefore, developing a novel magnolol formulation with improved oral bioavailability may enhance its therapeutic effects.