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Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
A feature of type 2 diabetes and visceral adiposity is a chronic inflammatory state during which inflammatory cytokines such as tumor necrosis factor-α, interleukin-6 and interleukin-1β generate nephropathy and retinopathy.231,232 Ethanol extract of flowering parts of Lonicera japonica Thunb. (containing 65.3 µg/g of cholorogenic acid) given orally to streptozotocin-induced diabetic rats (plasma glucose ≥350 mg/dL) orally at a dose of 200 mg/kg/day for 8 weeks attenuated body weight loss, lowered glycemia from 421.5 to 303.8 mg/dL (normal: 93.6 mg/dL; rosiglitazone: 256.3 mg/dL) and HbA1c from 14.1% to 10.8% (normal: 4.8%; rosiglitazone: 4.8%).233 This regimen lowered urine volume, proteinuria, serum creatinine from 95.3 to 68.6 µmol/L (normal: 38.1 µmol/L; rosiglitazone: 59.2 µmol/L).233 This extract lowered renal contents of interleukin-6, tumor necrosis factor-α and transforming growth factor-β1 and increased interleukin-10 towards normal.233 Interleukin-10 induces insulin receptor substrate-1 tyrosine phosphosphorylation acting as an insulin-sensitizing adipokine in adipose tissues.232 This extract prevented glomerular hypertrophy and expansion of the mesangial in diabetic rodents, decreased by about 30% CD4+ and CD8+ T cell expressions in kidneys and reduced the phosphorylation of p38 mitogen-activated protein kinase in renal tissues.233 Clinical trials are warranted.
Simiao Qingwen Baidu decoction inhibits Epstein–Barr virus-induced B lymphoproliferative disease and lytic viral replication
Published in Pharmaceutical Biology, 2021
Xianhui Yang, Lingling Liu, Huijuan Zhang, Xiaoxu Sun, Yongbin Yan, Ruiying Ran
Simiao Qingwen Baidu decoction (SQBD) is a Chinese traditional medicine that has as the major components: gypsum fibrosum, Anemarrhena asphodeloides Bunge (Agavoideae), cornu bubali, Acutellaria baicalensis Georgi (Lamiaceae), Rehmannia glutinosa (Gaertn.) DC. (Orobanchaceae), Paeonia obovata Maxim. (Paeoniaceae), Scrophularia ningpoensis Hemsl (Scrophulariaceae), Forsythia suspense (Thunb.) Vahl (Oleaceae), Paeonia suffruticosa Andr., Platycodon grandiflorus (Jacq.) A. DC. (Campanulaceae), Lonicera japonica Thunb. (Caprifoliaceae), Angelica sinensis (Oliv.) Diels (Apiaceae), Prunella vulgaris Linn. (Lamiaceae), Bupleurum chinense DC. (Apiaceae) and Glycyrrhiza uralensis Fisch. ex DC (Fabaceae). SQBD is reported to have an anti-inflammatory effect on various acute and chronic inflammatory diseases (Yu et al. 2014). Previous research shows that SQBD has the pharmacological functions of anti-inflammatory, anticoagulant, protecting blood vessels, improving the blood circulation, inhibiting thrombosis and promoting fibrinolysis (Yan et al. 2016). However, the effect of SQBD on B lymphoproliferative disease and lytic viral replication is still unknown. Thus, we aimed to determine the mechanism of action of SQBD in EBV-induced B lymphoproliferative disease and lytic viral replication in vitro.
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
Published in Pharmaceutical Biology, 2023
Zhouman He, Jia Yuan, Yuanwen Zhang, Runfeng Li, Meilan Mo, Yutao Wang, Huihui Ti
Shuanghuanglian (SHL) preparation is simplified from the ‘Yinqiao San’ prescription recorded in the ‘Wenbing Tiaobian’ in the Qing Dynasty. It is composed of Lonicera japonica, Forsythia suspensa, and Scutellaria baicalensis. Modern medical research suggests that SHL oral liquid has broad-spectrum antiviral and immune-enhancing properties, thus it could be used as an effective broad-spectrum antiviral drug (Han et al. 2018). Baicalin and baicalein in SHL might be the 3CLpro inhibitors by affecting the replication of SARS-CoV-2 (Su et al. 2020).
TiO2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of lonicera japonica thunb
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Jinhua Zhu, Danyang Zhou, Dandan Wu, Wei Liu, Xiuhua Liu
The leaves of Lonicera japonica Thunb. were disposed as in Section 2.3 to obtain the crude extract. After that the crude extract was completely ultrasonically dissolved with deionised water, then it was subjected to fractional extraction with about three times the volume of petroleum ether, ethyl acetate and n-butanol, respectively. Each phase was concentrated under reduced pressure to obtain extracts of different polarities for following use.