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Cardiovascular Drugs during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Lisinopril is another ACE inhibitor. Among 29 infants with neonatal renal failure, two were born to women who used lisinopril during pregnancy (Rosa and Bosco, 1991). This drug is contraindicated in the second and third trimesters. Exposure to Lisinopril during the first trimester was reported among 20 infants, but no birth defects are recorded in the Swedish Birth Defects Registry (Kallen, 2019).
Medication Dosing and Adherence in Secondary Prevention
Published in James M. Rippe, Lifestyle Medicine, 2019
Ozlem Bilen, Nanette K. Wenger
Several clinical trials have shown that certain pharmacotherapies are efficacious in reducing the risk of MI, death, stroke, or recurrent coronary ischemia in patients surviving initial therapy for MI. Trials comparing low vs. high doses of these medications have demonstrated that optimal dosing is necessary to achieve the full clinical benefit of these therapies.1–3 For statins, two large clinical trials have shown that higher statin doses are superior in reducing the risk of rehospitalization and death after an AMI.4,5 A trial comparing low vs. high doses of lisinopril and a second comparative effectiveness study of different doses of both losartan and candesartan demonstrated that higher doses of these classes of medications reduced the risk of heart failure hospitalizations and death.2,3 Finally, for beta-blockers, two trials of heart failure patients showed that target doses of bucindilol and carvedilol were associated with greater improvement in ejection fraction, fewer hospitalizations, and lower mortality compared with low or moderate doses.1,6
Practice circuit 1
Published in T. Justin Clark, Arri Coomarasamy, Justin Chu, Paul Smith, Get Through MRCOG Part 3, 2019
T. Justin Clark, Arri Coomarasamy, Justin Chu, Paul Smith
You were diagnosed with Type 2 diabetes mellitus last year and this is being controlled with diet and oral medication (Metformin 500 mg TDS). Your last HBA1c result was 68. At the same time, as being diagnosed with Type 2 diabetes mellitus, you were diagnosed with high blood pressure and were started on Lisinopril 20 mg once daily. You have no other medical or surgical history.
Angiotensin converting enzyme and angiotensin converting enzyme inhibitors in dermatology: a narrative review
Published in Expert Review of Clinical Pharmacology, 2022
Due to the COVID-19 pandemic, using the drugs that may affect ACE should be cautious. No evidence supports that prior use of ACEI would increase the risk of longer duration of hospitalization nor mortality, thus discontinuation of ACEI for cardiovascular diseases is not necessary [126–128]. Interestingly, the use of ACEI can treat COVID-19 vaccine-induced DIR to dermal hyaluronic acid fillers. As more people receive vaccination for COVID-19, it can be imagined that the prevalence of DIR to dermal hyaluronic acid may be higher. ACEI can play central for treatment of DIR and lisinopril is most commonly used which can control the symptoms within days [21]. There was one case reported with administration of lisinopril as prevention before the second dose of vaccination [21]. However, due to the limited cases, further studies are needed for the optimal administration time and dosage.
Delayed-onset granulomatous reaction presenting as chronic facial edema: a review of the diagnostic and therapeutic challenges
Published in Journal of Cosmetic and Laser Therapy, 2021
Dianne Carrasquillo-Bonilla, Karina J. Cancel-Artau, Aileen Santos-Arroyo
A 61 y/o male patient was referred to the dermatology clinic for recurrent facial swelling for the past 3 years. As the condition started, the patient referred inflammation involving the forehead for 2 months, followed by the periorbital region for 4 days, both of which resolved spontaneously. Six months after and up until now he noticed recurrent inflammation and induration on his forehead, glabella, and periocular area. He was evaluated by various specialists and responded partially to previous treatment with antibiotics and systemic steroids. Medical history was pertinent for hypertension treated with lisinopril with no known drug allergies. He denied any previous history of trauma or surgical intervention. He only recalled administration of “Botox” near the affected area about twenty years ago.
Adverse cutaneous effects of neratinib
Published in Journal of Dermatological Treatment, 2019
Ramiz N. Hamid, Christine S. Ahn, William W. Huang
A 52-year-old woman with HER-2 positive infiltrating ductal carcinoma of the right breast presented to the dermatology clinic with changes to her fingernails, adult-onset acne, and a rash on the lower legs. Her cancer regimen consisted of trastuzumab followed by extended adjuvant therapy with neratinib. She started neratinib five months prior to presentation for a planned one-year course. She began to notice dryness, swelling, and throbbing pain around the fingernails four months after initiation. The symptoms would disappear spontaneously and return affecting other digits. She also reported dry skin, acne-like lesions surrounding the mouth, and an asymptomatic rash on the lower legs that was present since chemotherapy and became more prominent after she started neratinib. Other home medications included atorvastatin, carvedilol, losartan, metformin, calcium carbonate, and aspirin, in addition to neratinib 240 mg daily. The patient reported no history of drug reactions other than a rash following exposure to lisinopril.