China 
Africa 
Explore chapters and articles related to this topic
Fusidate Sodium
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Fusidic acid was reported to cause symptoms of levomethadone withdrawal in 4 of 44 HIV-infected drug addicts (Brockmeyer et al., 1991). This may have occurred as a result of either competition for metabolism in the liver or displacement because of the high serum protein-binding of fusidic acid. Three case reports of rhabdomyolysis secondary to concomitant treatment with simvastatin and fusidic acid suggested that fusidic acid somehow competes for metabolism with the cytochrome P3A4 enzyme system, which is known to take part in the metabolism of simvastatin (Yuen and McGarity, 2003).
Health-related quality of life in people receiving opioid agonist treatment and treatment for hepatitis C virus infection
Published in Journal of Addictive Diseases, 2023
Olav Dalgard, Alain H. Litwin, Oren Shibolet, Jason Grebely, Ronald Nahass, Frederick L. Altice, Brian Conway, Edward J. Gane, Anne F. Luetkemeyer, Cheng-Yuan Peng, David Iser, Isaias Noel Gendrano, Michelle M. Kelly, Barbara A. Haber, Heather Platt, Amy Puenpatom
Adults aged ≥18 years with HCV genotype 1, 4, or 6 infection and serum HCV RNA ≥10,000 IU/mL were enrolled. Participants were required to have received opioid agonist therapy for ≥3 months prior to screening and have kept ≥80% of scheduled appointments while on medication. Opioid agonist therapy included methadone, levomethadone, buprenorphine (alone or in combination with naloxone), or naltrexone. Participants were naive to previous treatment for HCV infection and had no cirrhosis (i.e., liver biopsy showing absence of cirrhosis with a FibroScan [Echosens, Paris, France] score ≤12.5 kPa or a FibroSure [LabCorp, Burlington, NC, USA] score ≤0.48 and an aspartate aminotransferase-to-platelet ratio index [APRI] of ≤1) or had compensated cirrhosis (liver biopsy showing cirrhosis with a FibroScan score of >12.5 kPa or a FibroSure score of >0.75 and an APRI of >2). Planned enrollment allowed for up to 20% of patients with compensated cirrhosis.11
Outcome of patients who taper off opioid maintenance during in-patient rehabilitation treatment for opiate use disorder. A controlled multicenter study
Published in Journal of Substance Use, 2018
Michael Specka, Thomas Kuhlmann, Karin Feugmann, Wilma Funke, Martina Pietras, Yvonne Post, Andreas Rhode, Norbert Scherbaum
Tapering off the maintenance drug was started 1–2 days after admission in two clinics, and about 2 weeks after admission in the other two clinics. In individual cases, taper started later than usual. Buprenorphine was the maintenance drug for 21.1%, racemic methadone for 48%, and levomethadone for 30.8%. Using a 1:5 ratio for calculating equivalence doses between buprenorphine and racemic methadone (Schottenfeld, Pakes, Oliveto, Ziedonis, & Kosten, 1997), and a 1:2 ratio for levomethadone versus racemic methadone, the median initial dose was 40 mg racemic methadone (-equivalent) for the total group and also in each clinic. Methadone (-equivalent) was reduced by 1.3 mg/d, on average (SD 1.6). This rate varied from 1.0 to 1.7 between clinics.