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Nanocarriers Systems and Their Application for the Delivery of Different Phytoconstituents
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Ebru Altuntaş, Gülgün Yener, Burcu Özkan
The pharmacokinetic profiles belonging to isorhamnetin, quercetin, and kaempferol existing within the extract of Ginkgo biloba (GbE) have been shown by Chen et al. following an oral administration in rats by preparing a formulation of its phospholipid complex (Chen et al., 2010). According to the results, the Cmax of isorhamnetin demonstrated an increase from 195.96 to 672.29 ng/mL, from 179.21 to 724.89 ng/mL in case of quercetin and from 180.23 to 323.56 ng/mL in case of kaempferol. The AUC (0 ~ T) of isorhamnetin, quercetin, and kaempferol of the Ginkgo biloba phospholipid complex in relation to GbE have been determined to increase by 2.35, 2.42, and 1.95 times, respectively. The Tmax of these three components was determined to be shorter with the phospholipid complex than that of the crude extract. Additionally, the results revealed that the biological availability of the extract in phospholipid complex showed a large increase in individual increases in quercetin, kaempferol, and isorhamnetin. The increase in bioavailability exhibited by the phospholipid complex was higher than that of the solid dispersion.
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
There are no specific references in the literature to antidiabetic effects of Hemerocallis citrina. However, several of the plant’s primary phytochemical components, including quercetin,9 kaempferol,10 and isorhamnetin11 have been to exhibit significant antidiabetic and anti-Metabolic Syndrome activities.
Nelumbo nucifera
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Pulok K. Mukherjee, Debayan Goswami, Bhaskar Das, Subhadip Banerjee
The IC50 values for hydroxyl radical scavenging activity and superoxide radical scavenging activities of procyanidins, isolated from the non-edible parts of lotus seed pod were determined to be 10.5 and 17.6 mg/L, respectively (Ling et al. 2005). Butanol extract of leaves inhibited free radicals and suppressed intracellular ROS generation in hydrogen peroxide-treated cells and increased cell viability (Je and Lee 2015). Isorhamnetin glycosides from the stamens showed antioxidant activities (Hyun et al. 2006). N. nucifera showed significant hypocholesterolaemic and antioxidant properties by modulating erythrocyte function and structural abnormalities (Sasikumar et al. 2012). Also four different chemical analyses resulted in high antioxidant activity from the rhizome knot (Hu and Skibsted 2002).
Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model
Published in Pharmaceutical Biology, 2021
Lu Dou, Xue Gong, Qing Wu, Fangzheng Mou
In recent years, with the popularization of systems biology, network pharmacology has become an important tool for analyzing the performance of TCM (Zhang et al. 2019; Cui et al. 2020; Sinan et al. 2020). According to the absorption, distribution, and metabolism, excretion analysis (ADME) principle, we predicted and found the main active components of SXF to be flavonoids (e.g., isorhamnetin and luteolin), kaempferol, and amino acids (arginine, histidine, and lysine) (Table S1). The cytotoxic effects of CTX include induction of free radical production and increased oxidative stress. CTX disrupts antioxidant systems, decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) activity, and increases malondialdehyde (MDA) activity (Tripathi and Jena 2009; Athira et al. 2020; Niu et al. 2020). When the oxidative-antioxidant system is imbalanced, it results in common diseases and various ageing diseases. Isorhamnetin has been shown to have anti-inflammatory, anticancer, and antioxidant activities (Shi et al. 2018; Kim et al. 2019). Luteolin has antiallergic, anti-inflammatory, and anticancer functions (Deng et al. 2017), and kaempferol can affect cell survival and apoptosis and has antioxidant effects (Seydi et al. 2018). The GO results of SXF action target showed that the redox activity process was also enriched. In conclusion, our results suggested that SXF may restore haematopoiesis by reducing the oxidative damage caused by CTX to the organism's haematopoietic system, thereby improving the body's ability to resist chemotherapy drug-induced aplastic anaemia.
Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis
Published in Immunopharmacology and Immunotoxicology, 2019
Sen-Wei Tsai, Chi-Chien Lin, Shih-Chao Lin, Shun-Ping Wang, Deng-Ho Yang
Natural compounds obtained from plants have been widely and safely consumed for centuries. Many studies indicate that plant derived natural products have a wide range of diverse biological activities with mild adverse reactions. Therefore, natural products have been widely studied as adjuvant therapeutic agents in treatment of OA [5–7]. Isorhamnetin is a plant flavonoid abundant in herbal medicinal plants such as Hippophae rhamnoides L. and Ginkgo biloba L., has been used to treat various diseases in traditional medicine. The diverse pharmacological functions of Isorhamnetin include anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and anticancer activities [8–11]. It is worth noting that recent study reported that isorhamnetin exhibited anti-inflammatory and chondroprotective effects in IL-1β-stimulated chondrocytes [12]. However, the efficacy and molecular mechanism of this compound in the treatment of OA have not been investigated. Therefore, the aim of this study was to investigate the anti-osteoarthritis activities and underlying mechanism of isorhamnetin in a monosodium iodoacetate (MIA)-induced OA model rats.
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
Published in Drug and Chemical Toxicology, 2023
Huseyin Gungor, Mehmet Ekici, Mehmet Burak Ates
Flavonoids are natural substances found in vegetables, fruits, stems, roots, tea, wine, and flowers and are traditionally used to treat various liver diseases. They have a wide range of biological activities such as antioxidant, anticarcinogenic, anti-inflammatory, and antimutagenic effects, as well as the ability to alter CYP enzymatic activity (Panche et al.2016). Isorhamnetin is a hepatoprotective flavonoid molecule that is a metabolite of quercetin (Kim et al.2013), derived from the leaves and fruit of Hippophae rhamnoides. It has been previously shown that isorhamnetin has various biological effects, including antioxidant, anti-inflammatory, anti-apoptotic, and anti-cancer properties (Li et al.2016, Lu et al.2018).