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Cellular Components of Blood
Published in Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal, Principles of Physiology for the Anaesthetist, 2020
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal
Hb contains 65%–70% of the total body iron, with myoglobin containing 4%–5%. Iron is also associated with cellular respiration through the action of iron-containing enzymes such as cytochromes, catalase and peroxidase. Iron is transported in plasma by transferrin, a β1-globulin that binds two atoms of ferric iron per molecule. The main source of iron carried by transferrin is from the reticuloendothelial cells that destroy ageing red cells. Some iron is also stored in the reticuloendothelial cells as haemosiderin and ferritin. Ferritin is a water-soluble protein–iron complex consisting of an outer protein shell, called apoferritin, and an inner core of iron–phosphate–hydroxide complex.
Medicines for Weakness: 1900 to c. 1950
Published in John K. Crellin, A Social History of Medicines in the Twentieth Century, 2020
The just mentioned Iron Phosphate Compound, often prescribed alone by Newfoundland physicians, albeit "disguised" for the patient by the pharmaceutical Latin of the prescriptions, was, in fact, available over the counter as the well-known Parrish's Chemical Food. An example of common ground between many conventional and overthe-counter medicines, it became especially popular for children until the 1950s. Countless versions of the Chemical Food (modifications of Parrish's original formula) were marketed by companies as well as by individual pharmacies. At least three local Newfoundland brands were marketed, the labeling of which raises interesting questions about the quality of professional services.113
Physiology of blood
Published in Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal, Principles of Physiology for the Anaesthetist, 2015
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal
Hb contains 65% –70% of the total body iron, with myoglobin containing 4% –5%. Iron is also associated with cellular respiration through the action of iron-containing enzymes such as cytochromes, catalase and peroxidase. Iron is transported in plasma by transferrin, a β1-globulin that binds two atoms of ferric iron per molecule. The main source of iron carried by transferrin is from the reticuloendothelial cells that destroy ageing red cells. Some iron is also stored in the reticuloendothelial cells as haemosiderin and ferritin. Ferritin is a water-soluble protein–iron complex consisting of an outer protein shell, called apoferritin, and an inner core of iron–phosphate–hydroxide complex.
Current and potential treatment options for hyperphosphatemia
Published in Expert Opinion on Drug Safety, 2018
Fabio Carfagna, Lucia Del Vecchio, Giuseppe Pontoriero, Francesco Locatelli
The presence of iron confers to these drugs the ability to bind phosphorus in the GI lumen. Iron(III)-oxyhydroxide is the pharmacologically active part of a compound named sucroferric oxyhydroxide (Velphoro®, PA21) and consists of a mixture of polynuclear iron(III)-oxyhydroxide, sucrose, and starches. Iron(III)-oxyhydroxide is nearly insoluble and this, although not completely, prevents iron from being absorbed by the iron transporters of the duodenum [51]. Sucroferric oxyhydroxide adsorb phosphate in the iron complex and form iron phosphate compound through a chemical reaction that is favored by low pH values, such as those present within the stomach [50]. Sucroferric oxyhydroxide showed minimal iron absorption, albeit some changes in iron-related parameters are observed following treatment [52,53].