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Roller Compaction Technology
Published in Dilip M. Parikh, Handbook of Pharmaceutical Granulation Technology, 2021
Ronald W. Miller, Vishwas Nesarikar
Table 8.2 shows that hydroxypropyl methylcellulose is the preferred polymer for use in extended-release roller compaction formulations. Hydroxypropyl cellulose and ethylcellulose polymers are also significantly preferred, followed by methylcellulose and various methacrylate polymers. The polymer preferences for extended-release formulations, using roller compaction technology, appeared to reflect polymer usage that is associated with matrix extended-release systems.
Thickening Agents
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Ricardo D’Agostino Garcia, Antony O’Lenick, Vânia Rodrigues Leite-Silva
Hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties that contribute to its utility in formulation. It combines organic solvent solubility, thermoplasticity, and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers. The hydroxypropyl substitution confers increased lipophilicity on HPC than other water-soluble cellulose derivatives, a key difference when formulating with alcohol-based formulations. Accordingly, it is compatible with a wide range of anionic, nonionic, cationic and amphoteric surfactants. The viscosity of water-based solutions of HPC is not affected by changes in pH over the range of 2 to 11. Applications using HPC as a thickener include hairstyling aids, alcohol-based preparations, perfumes and colognes, shampoos, emulsion creams, and lotions.
Non-Gelatin-Based Capsules
Published in Larry L. Augsburger, Stephen W. Hoag, Pharmaceutical Dosage Forms, 2017
Another recent development reported the use of hydroxypropyl cellulose (HPC) for two-piece capsule manufacturing using an injection molding process. These capsules take advantage of the HPC swelling and erosion properties in order to achieve a capsule with pulsatile release characteristics. The release characteristics can be modified using different grades of HPC, and the shell wall thickness can be modified as well in a range between 300 and 900 μm. The capsules by itself, when filled with acetaminophen and sealed by application of an HPC solution on the cap and body junction, showed a thickness-dependent lag time in dissolution ranging from about 15 to 70 min for the 300- and 900-μm shell thickness, respectively (Gazzaniga et al. 2011). In a successive trial, the same group applied different levels of Eudragit L30 D 55 through spray coating to sealed and unsealed capsules, demonstrating further delay in the in vitro dissolution, suggesting its suitability for colonic drug delivery (Macchi et al. 2015). Further studies will be required to prove its clinical performance and technical feasibility on a commercial scale.
Optimization of a solidified micelle formulation for enhanced oral bioavailability of atorvastatin calcium using statistical experimental design
Published in Pharmaceutical Development and Technology, 2023
Yoon Tae Goo, Yong-Hoon Won, Sun Ho Hong, Ji Yeh Choi, Gi Hyeong Sin, Chang Hyun Kim, Hyun Min Jung, Young Wook Choi
ATV powder (purity >99%) was contributed by Chong Kun Dang (Seoul, Korea). Lipitor® tablets containing 40 mg ATV were provided by Viatris Korea. Aerosil 200 (CAS 7631-86-9) was supplied by Evonik Degussa GmbH (Frankfurt am Main, Germany). Avicel PH 101 (CAS 9004-34-6), Brij L4 (BL4; CAS 9002-92-0) and Tween 20 (T20; CAS 9005-64-5) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Florite PS-10 (FLO; calcium silicate; CAS 1344-95-2) was obtained from Tomita Pharmaceutical Co., Ltd. (Tokushima, Japan). G48 was kindly gifted by Gattefosse (Saint Priest, France). Kolliphor EL (CAS 61791-12-6), Kolliphor RH40 (CAS 61788-85-0), and Kolliphor RH60 were obtained from BASF (Ludwigshafen, Germany). Low-substituted hydroxypropyl cellulose B1 (L-HPC; CAS 9004-64-2) was furnished by Shin-Etsu Chemical Co., Ltd. (Tokyo, Japan). Neusilin US2 (magnesium aluminometasilicate; CAS 12511-31-8) was supplied by Fuji Chemical Industry Company (Toyama, Japan). Vivapur 105 (VP105; CAS 9004-34-6) was provided by JRS Pharma (Rosenberg, Germany). High-performance liquid chromatography (HPLC)-grade methanol was purchased from JT Baker (Phillipsburg, NJ, USA). All other chemicals used were of analytical grade.
Stability screening of pharmaceutical cocrystals
Published in Pharmaceutical Development and Technology, 2021
Kenneth C. Waterman, Alisa K. Waterman, Teslin M. Botoy, Jane Li, Fenghe Qiu, Michael Hawley
All cocrystals and un-complexed drugs were provided by Boehringer Ingelheim Pharmaceuticals, Inc. microcrystalline cellulose, MCC (Avicel® PH 102 NF) was received from Mutchler (Harrington Park, NJ). Sodium hydroxide, D- lactose and ammonium phosphate dibasic were purchased from Fisher Scientific (Fair Lawn, NJ). Sodium starch glycolate (SSG), magnesium stearate (MgSt), and croscarmellose sodium (CCS) were purchased from Spectrum (Gardena, CA). Hydroxypropyl cellulose, HPC (Klucel™ EF Pharm), was supplied by Ashland (Wilmington, DE).Mannitol, ammonium dihydrogen phosphate, ammonium acetate, acetonitrile (ACN), phosphoric acid, and povidone, PVP (K30), were purchased from Millipore Sigma (St. Louis, MO). YMC Pack Pro C8 100 × 3 mm 3.0 µm column was purchased from YMC (Japan). Waters X-Bridge C18, 100 × 3.0 mm, 3.5 µm, and X-Bridge Shield RP18 100 × 3.0 mm 3.5 µm columns were purchased from Waters (USA). Nylon syringe filters (0.45 µm) were purchased from Omicron Scientific (Alpharetta, GA). A Waters 2695 separation module with a 2996 PDA detector was used (Milford, MA) with the HPLC data analyzed using Empower 3 software.
Evaluation about wettability, water absorption or swelling of excipients through various methods and the correlation between these parameters and tablet disintegration
Published in Drug Development and Industrial Pharmacy, 2018
Baixue Yang, Chen Wei, Yang Yang, Qifang Wang, Sanming Li
MCC as the filler was supplied by Tianjin Guangfu Fine Chemical Research Institute (Tianjin, China). Mannitol obtained from Beijing Fengli Jingqiu Commerce Co., Ltd. (Beijing, China) was used as excipient and flavoring agent. Crospolyvinylpyrrolidone (PVPP, Kollidon CL) was purchased from BASF AG (Ludwigshafen, Germany). Low-substituted hydroxypropyl cellulose (L-HPC) was provided by Sunshere Pharmaceutical Excipient Co., Ltd. (Anhui, China). Carboxymethyl starch sodium (CMS-Na) was a gift from Huzhou Zhanwang Pharmacy Co., Ltd. (Zhejiang, China). Croscarmellose sodium (CCMC-Na) was obtained from Eli Lilly and Company (Shanghai, China). PVPP, L-HPC, CMS-Na and CCMC-Na were all used as superdisintegrants. Magnesium stearate (MgSt) was purchased from Tianjin Chemical Reagent Co., Ltd. (Tianjin, China) and used as lubricant and glidant. Rhodamine B was supplied by Tianjin Bodi Chemical Co., Ltd. (Tianjin, China). Loratadine provided by Nanjing Zhuo Pu Biotechnology Co., Ltd. (Nanjing, China) was selected as model drug. In the capillary rise test, 97% pure n-hexane was used as the completely wetting liquid. Redistilled water was produced by our laboratory.