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Ultraviolet and Light Absorption Spectrometry
Published in Adorjan Aszalos, Modern Analysis of Antibiotics, 2020
Zoltan M. Dinya, Ferenc J. Sztaricskai
Hetacillin content is controlled by colorimetric estimation of a condensation product formed between liberated ampicillin and p-dimethylaminocinnamalde-hyde. The phenethicillin content of phenethicillin potassium is determined in the Code of Federal Regulations [16] by an UV absorption measurement. UVVrS has been found valuable in elucidation of the structure of some degradation products of penicillin, and in connection with this several excellent review articles are available [47,48,51],
Drugs repurposing for SARS-CoV-2: new insight of COVID-19 druggability
Published in Expert Review of Anti-infective Therapy, 2022
Sujit Kumar Debnath, Monalisha Debnath, Rohit Srivastava, Abdelwahab Omri
Similarly, another study reported IPB02 (HR2 sequence-based lipopeptide fusion inhibitor) demonstrated an influential inhibitory role against S protein-mediated membrane fusion [57]. Another in-silico screening study with docking and molecular dynamics simulation was carried out [58]. As a result of this study, seven compounds were selected from the drug bank library for molecular dynamics analysis based on their docking score and ligand binding efficiency towards the S-protein-ACE interface. These are mefloquine (DB00358- antimalarial drug), phenolphthalein (DB04824- laxatives) and bisoxatin (DB09219- laxatives), ketoprofen (DB01009- analgesic-antipyretic drug), hetacillin (DB00739), doravirine (DB12301- HIV-1 reverse transcriptase inhibitor), and riociguat (DB08931- a drug that treats pulmonary arterial hypertension). Seven other drugs were selected from the PubChem database based upon their docking score. These are silymarin (hepatoprotective agent), bisindolylmaleimide VIII and X (anti-inflammatory, anti-asthmatic, and protein kinase inhibitors), lensiprazine (an antipsychotic drug), Naphthalenenitrile 9ac (L-708, 780-lipoxygenase inhibitor), CX-659S (anti-inflammatory and anti-oxidative drug), and talazoparib (antineoplastic drug). Among them, bisoxatin is a lead compound that prevents interaction between spike protein and host cell. A fibronectin-derived anticancer peptide, ATN-161, can effectively against COVID-19 [57]. This drug has binding efficiency with both S-protein as well as with ACE. Therefore, it prevents the interaction between S protein and ACE by saturating the binding interface. Several clinical trials revealed arbidol (an anti-influenza drug) could prevent S protein-associated membrane fusion.
Successes, failures, and future prospects of prodrugs and their clinical impact
Published in Expert Opinion on Drug Discovery, 2019
Hetacillin (22 in Figure 3) is an ester prodrug of ampicillin which was withdrawn since it offered no superior advantages when compared to ampicillin. It is, however, prescribed in veterinary medicines [72].