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THERAPEUTIC BIOLOGY OF Gmelina asiatica Linn
Published in V. R. Mohan, A. Doss, P. S. Tresina, Ethnomedicinal Plants with Therapeutic Properties, 2019
S. Jeeva, A. R. Florence, R. Mary Sujin
Gas chromatography–mass spectroscopy (GC–MS) analysis, nine bioactive phytochemical compounds were identified in the methanolic leaf extract of G. asiatica by Azhagumurugan and Rajan (2014). Methanol extract of heart wood powder fraction contains crystalline components such as methyl p-methoxy-cinnamate, sitosterol, paulownin, gmelinol, methyl-p-hydroxy-cinnamate, and cycloolivil lignans (Anjaneyulu et al., 1975). The phytoconstituents isolated from the G. asiatica roots contain (+) sesamin, (-) pinoresinol, (-) piperitol, sakuranetin, ovalifolin (Satyanarayana et al., 2007; Balijepalli et al., 2010), and nitidine (Gakunju et al., 1995). Triglycerides (10.1%) and 2-monoglycerides (1.6%) were recovered by thin-layer chromatographic method from G. asiatica seeds (Gunstone and Quresh, 1965).
Standardized aqueous stem bark extract of Gmelina arborea roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats
Published in Drug and Chemical Toxicology, 2022
Sachinthi S. Amarasiri, Anoja P. Attanayake, Liyanagae D. A. M. Arawwawala, Kamani A. P. W. Jayatilaka, Lakmini K. B. Mudduwa
Extensive research has been conducted on the stem bark of the plant for the investigation of bioactivities including anti-inflammatory, antioxidant, antimicrobial, antipyretic, gastroprotective, anti-diabetic, diuretic etc. (Attanayake et al. 2015, Lawrence et al. 2016, Kaur et al. 2018). No signs of toxicity have been reported for the methanol and aqueous extracts of GA stem bark in animal models (Kaur et al. 2018). Further, tyrosol, balanophonin, gmelinol, phenylethanoid glycoside, 2,6-dimethoxy-p-benzoquinone and 3,4,5-trimethoxyphenol were identified as bioactive compounds in the stem bark of GA (Lawrence et al. 2016). However, nephroprotective effect of GA stem bark has not been scientifically investigated to date. Herein, an attempt was taken to evaluate the nephroprotective activity of the aqueous extract of standardized GA stem bark against ADR induced nephrotoxicity in Wistar rats.