Glucal

Glucal

Halogen Labeled Compounds (F, Br, At, Cl) ^*

Published in Garimella V. S. Rayudu, Lelio G. Colombetti, Radiotracers for Medical Applications, 2019

The synthesis by direct fluorination with F2 in the electrophilic reactions is usually rapid. F2 is not extensively employed because of its high reactivity and low selectivity. However, diluted F2 can lead to a more controllable situation. 18F-5-Fluorouracil was prepared from uracil and 18F2 in glacial acetic acid.13, 101, 10218F-5-Fluorocytosine was similarily prepared.92 Reaction of 18F2 with 3,4,6-tri-O-acetyl-D-glucal followed by subsequent acid hydrolysis leads to the formation of 18F-2-deoxy-2-fluoro-D-glucose.49, 97 Theoretically only 50% of the fluorine activity can be incorporated into the product by direct fluorination methods.

Synthesis, antiasthmatic, and insecticidal/antifungal activities of allosamidins

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Journal Information

Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2019

Gangliang Huang, Hualiang Huang

Rhodium-catalyzed oxidative cyclization of glucal 3-carbamates to oxazolidinone-protected mannosamine derivatives (Scheme 2)49 could be used to synthesize various allosamidin analogues. The stereoselectivity of anomeric centers relied on the properties of protective groups and solvents. It was proved that benzyl protection mainly produced a product of α-configuration. Solvents with lower polarity, such as hexane and benzene, also increased the anomeric proportion. Its formation was with a primary amide containing carbamate as a raw material.

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Halogen Labeled Compounds (F, Br, At, Cl) *

Synthesis, antiasthmatic, and insecticidal/antifungal activities of allosamidins

Halogen Labeled Compounds (F, Br, At, Cl) ^*