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The Roman Empire
Published in Scott M. Jackson, Skin Disease and the History of Dermatology, 2023
Finally, Galen deserves recognition for several other contributions to the history of dermatology. He was the first to use the term psora to name an itchy, scaly skin condition that affected the eyelids and scrotum, which was more likely a description of seborrheic dermatitis than psoriasis.97 He was the first to describe a pustular disease of the mouth called febris pemphigodes, which some have suggested was pemphigus vulgaris. The word “Galenical” refers to his pharmacological prowess for concocting medications with plant or animal ingredients, and Galenic formulation is a term still used today that means the process by which a topical medication is formulated to optimize absorption. Galen is also credited with inventing the cold cream used for skin beautification.
Immunosuppression strategies in lung transplantation
Published in Wickii T. Vigneswaran, Edward R. Garrity, John A. Odell, LUNG Transplantation, 2016
Miranda A. Paraskeva, Glen P. Westall, Greg I. Snell
Tacrolimus in a twice-daily formulation has been used in SOT for a number of decades. More recently, a once-daily or extended-release formulation has become available. Although it has been used with other SOT groups,51–53 the new formulation has only recently been incorporated into routine lung transplant regimens. Tacrolimus XL is a modified galenic formulation that allows once-daily administration. It was designed to provide an area under the concentration-time curve from 0 to 24 hours (AUC0-24) similar to that of the twice-daily formulation and with equivalent efficacy and safety.53
Cannabidiol use in patients with Dravet syndrome and Lennox-Gastaut syndrome: experts’ opinions using a nominal group technique (NGT) approach
Published in Expert Opinion on Pharmacotherapy, 2023
Paolo Bonanni, Francesca Ragona, Carlo Fusco, Antonio Gambardella, Francesca Felicia Operto, Lucio Parmeggiani, Stefano Sartori, Nicola Specchio
The NGT results highlighted some key points regarding CBD use in patients with DS and LGS. The complete results are reported in Table 3. The pharmaceutical formulation of purified CBD could be used for the treatment of DEEs, other than DS and LGS, in agreement with recent studies in the literature which showed CBD efficacy in children and adults with epileptic syndromes and seizures [31,32].The use of a purified pharmaceutical CBD, approved by a regulatory body, is preferable to a galenic formulation, as the concentration and purity of CBD have a minimal variability than a galenic where the content is instead highly variable. Furthermore, the amount of CBD administered to the patient through the use of an approved pharmaceutical CBD is more reliable than a galenic formulation, due to greater control of the administered dose and consequently a lower risk of adverse events.
Therapy for pruritus in the elderly: a review of treatment developments
Published in Expert Opinion on Pharmacotherapy, 2018
Manuel P. Pereira, Sonja Ständer
The application of less irritating cleansing products, moisturizers containing humectants, and products with occlusives seems to be the most effective strategy for maintaining the integrity of the skin barrier [15] and thus to avoid itch. If itch is present with dry skin, several emollients with antipruritic active substances such as urea, polidocanol, menthol, or palmitoylethanolamide are beneficial and should be frequently applied [9]. Importantly, the galenic formulation of the emollient needs to be adapted in accordance with the skin status of the patient. For very dry skin, ointments with a high fat content are preferable while creams or lotions may be applied to less xerotic skin.
The emerging role of skin microbiome in atopic dermatitis and its clinical implication
Published in Journal of Dermatological Treatment, 2019
Jean-François Stalder, Joachim W. Fluhr, Tim Foster, Martin Glatz, Ehrhardt Proksch
As well as adopting a multifaceted treatment approach, assuring patient treatment adherence is a key priority for AD management, but remains an issue. Optimal galenic formulation should be considered when developing AD care products and different solutions should be available to suit different patient needs. Ingredients used in AD products must be selected carefully to ensure that they are effective, without irritating sensitive skin. Finally, effective communication between healthcare professional and patient is essential for supporting individuals living with AD to feel confident and clear in how they can optimally manage their AD.