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Analgesics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
NSAIDs used infrequently during pregnancy (<5 percent) include fenoprofen, tolmentin, rofecoxib, celecoxib, and etodolac. Importantly, each of these drugs are prostaglandin synthetase inhibitors, and may theoretically cause premature closure of the ductus arteriosus and/or oligohydramnios based upon experience with better studied NSAIDs that have highly similar modes of action.
Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
One patient sensitized to ibuprofen may have cross-reacted to flurbiprofen and fenoprofen (3). An individual who had photoallergic contact dermatitis from ketoprofen showed cross-photosensitivity to flurbiprofen and ibuproxam (4). A patient with photocontact allergy to tiaprofenic acid photocross-reacted to flurbiprofen (5).
An Overview of Drug-Induced Nephropathies *
Published in Robin S. Goldstein, Mechanisms of Injury in Renal Disease and Toxicity, 2020
Jean Paul Fillastre, Michel Godin
A distinct clinical syndrome associated with NSAID exposure and completely different from the renal failure described previously due to enhanced renal vasoconstriction has become apparent in the last several years. This disorder is characterized by an interstitial nephritis on renal biopsy, but often presents clinically as the nephrotic syndrome. The first 2 cases of acute renal failure with nephrotic syndrome were reported in 1979 (Brezin et al., 1979) and more than 100 cases have been described since. The incidence of this unusual disorder is unknown, but is believed to be rare. It seems to be more frequent when propionic acid derivatives are prescribed. Fenoprofen was implicated in a large number of cases.
Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion
Published in Pharmaceutical Development and Technology, 2021
Marwa Hassan Shukr, Omar A. Ahmed Farid
To the glass tubes containing 0.5 mL of the separated plasma or the homogenized brain samples 50 µL of internal standard solution (20 µg/mL fenoprofen) was added and vortexed for 1 min. Then, tertiary butylmethyl ether (4 mL) was added as extraction solvent and mixed for 10 min. Samples were centrifuged for 10 min at 4 °C and 4000 rpm, using eppendorf centrifuges and upper organic layer was separated and evaporated to dryness under vacuum. Dry residues were dissolved in 0.25 mL of the mobile phase, and were vortexed for 1 min, AGO in plasma and homogenized brain samples were measured using a validated HPLC method (Abuseada 2012). Analysis was conducted using Cyano C18 column (250 × 4.6 mm, 5 μm). The mobile phase composed of trifluoroacetic acid buffer and methanol (50:50) and using Agilent 1260 HPLC system, Agilent, USA. The wave length of the detection is 230 nm at a flow rate 1 mL/min. Fenoprofen was used as internal standard (20 µg/mL).
Microemulsion for topical delivery of fenoprofen calcium: in vitro and in vivo evaluation
Published in Journal of Liposome Research, 2018
Dalia Ali Farghaly, Ahmed A. Aboelwafa, Manal Y. Hamza, Magdy I. Mohamed
Fenoprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory agent used in the management of pain, inflammation and stiffness associated with osteoarthritis and rheumatoid arthritis. It is also used to relieve mild to moderate pain. It is given as the calcium salt (dihydrate). Oral therapy of fenoprofen calcium (FPCa) is effective, but the clinical use is often limited because of the risk of severe gastrointestinal adverse effects such as irritation, ulceration and gastric bleeding (Sweetman, 2011). Therefore, topical administration of FPCa could be expected to be effective in avoiding the oral side effects as well as for targeting the drug to inflamed skin.
The effect of hyoscine-N-butylbromide on pain perception during and after hysterosalpingography in infertile women: a systematic review and meta-analysis of randomised controlled trials
Published in Human Fertility, 2022
Rehab Abdelhamid Aboshama, Mohammad Abrar Shareef, Abdulhadi A. AlAmodi, Wesam Kurdi, Mohammed M. Al-Tuhaifi, Marwah Ghazi Bintalib, Sileem Ahmed Sileem, Osama Abdelazem, Ahmed Mohamed Abdelhakim, Ahmed M. A. Sobh, Sahar M. Y. Elbaradie
In a Cochrane review, Hindocha et al. (2015) assessed the effectiveness of different pain medications used in HSG. They reported that intravenous opioids, topical anaesthesia, and local anaesthesia injection were effective in pain reduction during the procedure compared to placebo or no treatment. In addition, they found oral opioid and non-opioid analgesics were not beneficial in pain relief during and 30 minutes after the procedure. However, a survey by Duffy et al. (2008) found that administration of non-opioid analgesics (acetylsalicylic acid, acetaminophen, and fenoprofen) were commonly used by clinicians for pain prevention during HSG.