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The twentieth century
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Research on evening primrose and GLA began in earnest in the 1960s. John Williams, a research biochemist, manufactured capsules of evening primrose oil with the brand name Naudicelle. During the 1970s clinical research was carried out on the use of evening primrose oil in a number of medical conditions. Dr David Horrobin was instrumental in setting up the company Efamol Ltd. to develop, market and research evening primrose oil. The GLA of evening primrose oil was found to be a precursor of prostaglandin El, which was responsible for many of the medicinal benefits.
Fibromyalgia Syndrome: Canadian Clinical Working Case Definition, Diagnostic and Treatment Protocols–A Consensus Document
Published in I. Jon Russell, The Fibromyalgia Syndrome: A Clinical Case Definition for Practitioners, 2020
Anil Kumar Jain, Bruce M. Carruthers, Maijorie I. van de Sande, Stephen R. Barron, C. C. Stuart Donaldson, James V. Dunne, Emerson Gingrich, Dan S. Heffez, Y.-K. Frances Leung, Daniel G. Malone, Thomas J. Romano, I. Jon Russell, David Saul, Donald G. Seibel
Essential Fatty Acids [EFA] are essential for prostaglandin synthesis, cellular membrane integrity and help combat dry skin. In addition to eating fish of cold water origin, an EFA supplement is recommended, e.g., Salmon oil promotes nerve impulse transmission and blood flow.Evening Primrose oil promotes improved blood flow and neural function.
Medicinal Herbs
Published in Radhwan Nidal Al-Zidan, Drugs in Pregnancy, 2020
Risk Summary: The reproduction studies in animals have shown no evidence of fetal harm or impaired fertility. The pregnancy experience in humans is limited. In general, it does not represent a significant risk to the embryo-fetus. However, it should be kept in mind that Evening Primrose Oil has the ability to induce labor.
Evening primrose oil attenuates oxidative stress, inflammation, fibrosis, apoptosis, and ultrastructural alterations induced by metanil yellow in the liver of rat: a histological, immunohistochemical, and biochemical study
Published in Ultrastructural Pathology, 2023
Amany Mohamed Shalaby, Rania H. Shalaby, Mohamed Ali Alabiad, Doaa I. Abdelrahman, Mohammed Alorini, Fatima A. Jaber, Shaimaa Mohamed Abdelfattah Hassan
Herbs were formerly utilized as traditional remedies to manage various ailments, but they are today utilized in pharmacies, fragrances, nutritional supplements, and drinks.7 Evening primrose oil (EPO) is a popular traditional medicine that contains a variety of phytocompounds, such as flavonoids, tannins, esters, triterpenoids, phenolic acids, fatty acids, lactones, sterols, and chalcones.8 The radical-scavenging and anti-oxidant properties of EPOhave been proven in several investigations.9 It was also reported to have a potent lipoxygenase inhibitory action, supporting its anti-inflammatory properties.10 Previous studies emphasized its hypocholesterolemic, hypoglycemic, anti-bacterial, and anti-fungal effects.11 Vast clinical studies were conducted to evaluate the efficacy of EPO in the treatment of many disorders, including diabetic neuropathy, multiple sclerosis, rheumatoid arthritis, atopic eczema, heart disease, nephropathy, gastrointestinal problems, psychosis, alcohol dependence, and memory loss.12
Efficacy and Safety of Nutraceutical on Menopausal Symptoms in Post-Menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Published in Journal of Dietary Supplements, 2022
Teerapong Rattanatantikul, Mart Maiprasert, Pansak Sugkraroek, Akkarach Bumrungpert
Evening primrose oil contains a high content of essential fatty acids, gamma-linolenic acid. In a recent double-blind, randomized, placebo-controlled trial, it was reported that supplementation with evening primrose oil significantly reduced the severity of hot flushes in menopausal women with additional improvements in quality-of-life indicators of social and sexual activity (Farzaneh et al. 2013). For premenstrual syndrome, there is some evidence that gamma-linolenic acid can regulate the severity of symptoms. This was demonstrated in one trial of an essential oil extract containing gamma linolenic acids in 120 PMS sufferers, aged in their 30’s. After 6 months of daily consumption, an approximately threefold reduction in self-reported indices of symptom severity was observed during both the follicular and luteal phases (Beer et al. 2013). The anti-inflammatory properties of gamma-linolenic acid are useful in supporting menopause symptoms, to help alleviate symptoms associated with vasomotor function and neurological stress responses. Gamma-linolenic acid is further broken down to form prostaglandins, which can mediate vascular inflammatory responses to enable control of vasomotor symptoms (Rocha Filho et al. 2011).
Self-double-emulsifying drug delivery system incorporated in natural hydrogels: a new way for topical application of vitamin C
Published in Journal of Microencapsulation, 2018
Qiang Wang, Hong Zhang, Juan Huang, Nan Xia, Tong Li, Qiang Xia
Vitamin C (L-ascorbic acid, purity ≥99.7%) was supplied by Shanghai Titan Scientific Co., Ltd (Shanghai, China). Evening primrose oil was obtained from Guangzhou Boyi Trading Co., Ltd. (Guangzhou, China). Polyglycerol polyricinoleate (PGPR) was supplied by Shanghai Youchuang industrial Co., Ltd. (Shanghai, China). Tween 80 and glycerol were obtained from Sinopharm Chemical Reagent (Shanghai, China). Xanthan gum was purchased from Rhodia (France). Propyl p-hydroxybenzoate was supplied by Shanghai LEASUN Chemical Co., Ltd (China). 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) was purchased from Alading Co. Ltd. (Shanghai, China). Dulbecco’s modified Eagle’s medium (DMEM), 0.25% trypsin–EDTA solution, phosphate buffered saline (PBS), antibiotic solution (1% penicillin–streptomycin) and foetal bovine serum (FBS) were products of Hyclone (Thermo Scientific, USA). Double-distilled water was used in all experiments. All other chemicals and solvents were of analytical reagent grade.