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Anti-Inflammatory Activity of Wild Medicinal Plants of Piauí State-Brazil
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Valdiléia Teixeira Uchôa, Mahendra Rai, Gilmânia Francisca Sousa Carvalho, Herbert Gonzaga Sousa, Patrícia e Silva Alves, Renata da Silva Carneiro, Ariane Maria da Silva Santos Nascimento, Felipe Pereira da Silva Santos, Gabriel e Silva Sales
Erythrina velutina Willd, a species belonging to the Leguminoseae family, is a tree of great resistance to drought, endemic to Caatinga found in the coastal region of all northern and northeastern states, and is popularly known as mulungu, mulungu-da-flor-vermelha ou bucaré. This tree belongs to the order Fabales, subfamily Faboideae and genus Erythrina consisting of about 120 species, mainly trees and shrubs. It is commonly grown as an ornamental plant due to its attractive flowering and use in folk medicine (Menezes et al. 2016b).
Total Synthesis of Some Important Natural Products from Brazilian Flora
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Leonardo da Silva Neto, Breno Germano de Freitas Oliveira, Wellington Alves de Barros, Rosemeire Brondi Alves, Adão Aparecido Sabino, Ângelo de Fátima
In 2014, L'Homme et al. reported a concise approach for the total synthesis of the tetracyclic alkaloid erysotrine 35 (Figure 12.11) in nine steps and 0.1% overall yield. Erysotrine 35 is an alkaloid commonly isolated from plants of the Erythrina genus, a species that grows in tropical countries such as Brazil. Indeed, Sarragiotto et al. (1981) have isolated several alkaloids representative of the Erythrina species, including erysotrine 35, from methanolic extracts of finely ground flowers from Erythrina mulungu (Leguminosae; mulungu or mulungu-coral), a plant collected in the Santa Elisa farm from Campinas, Brazil (de Lima et al., 2006). For the synthetic odyssey proposed by Canesi and coworkers, a key step is the dearomatization of the phenolic A-ring of compound 36, promoted by hypervalent iodine with the aim of improving the reactivity of the enone 37. In sequence, the B-ring was constructed by an aza-Michael cyclization, followed by a Pictet-Spengler cyclization to afford the tetracyclic core (ABCD ring) of the desired alkaloid (Figure 12.11) (L'Homme et al., 2014). Despite the simple approach and short route, this strategy provides a very low overall yield.
Herbal Medicines in Neuropsychiatric Illness: The Case of L-Stepholidine
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Nitin Sati, Kedar S. Prabhavalkr, Sridhar Natesan, Lokesh K. Bhatt
The alkaloids isolated from Erythrina mulungu (Papilionaceae) exhibited anti-anxiety activity. The alkaloids erythravine and (+)-11alpha-hydroxy-erythravine were the phytochemicals responsible for the anxiolytic activity of the crude extract of E. mulungu.22 Same alkaloids isolated from the extract of flowers of the E. mulungu also exhibited anxiolytic activity.23 The hydroalcoholic extract of flowers of E. mulungu exhibited anti-convulsant and mild anxiolytic activity owing to the presence of alkaloid erythrosine. Erythravine (3, 10 mg/kg) and (+)-11alpha-hydroxy-erythravine (10 mg/kg) exhibited anxiolytic-like effect in animal models. Erythrosine (0.001–10 μg/mL) exhibited anti-convulsant and mild anxiolytic activities.24
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway
Published in Journal of Investigative Surgery, 2023
Shumei Li, Yajie Cui, Min Li, Wenting Zhang, Xiaoxue Sun, Zhaoxu Xin, Jing Li
We assessed the potential molecular mechanisms to further explore the protective role of ACT on bone formation and differentiation in GIOP Zhou et al. screened potential therapeutic targets for osteoporosis by informatics methods, and identified mTOR [34]. HIF-1α regulates GIOP through the AKT/mTOR signaling pathway [35]. More importantly, ACT derived from Radix Rehmanniae was shown to inhibit bone loss and structural deterioration and promote bone formation by acting on the PI3K/AKT/mTOR pathway [19]. Erythrina Sativa activates autophagy via the PI3K/AKT/mTOR pathway through involvement in rat osteoblast differentiation [22]. Resveratrol protects from OP by regulating the SIRT1 and PI3K/AKT/mTOR pathways [25]. Therefore, we focused on the PI3K/AKT/mTOR pathway in this study. We confirmed that Dex inhibited the levels of key proteins in these signaling pathways. In contrast, ACT attenuated this inhibition, and the protective functions of ACT on osteoblast viability, apoptosis, osteogenic differentiation, and mineralization were reversed with the addition of a signaling pathway inhibitor. This study in fact has some limitations to consider when explaining the findings. Firstly, it is unfortunate that HE histology was not provided to confirm our experimental results, which was a flaw in the initial design of our experiments. Furthermore, an osteoblast-like cell line, MC3T3-E1 cells, which are also commonly used in osteoporosis, was used in this study, and we will use primary osteoblasts or bone marrow stromal cells for in vitro studies in subsequent more in-depth studies.
Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice
Published in Pharmaceutical Biology, 2019
Xiao-Li Li, Li Sui, Fu-Hui Lin, Yin Lian, Lian-Zhong Ai, Yan Zhang
Erythrina variegata L. (Leguminosae) (EV), distributed in China, India, and Southeast Asia and of the same leguminous family as soybean, is used to treat rheumatic joint pain, spasm of the limbs as well as lower back and knee pain, and to stimulate lactation and menstruation for women (Zhang et al. 2007). We previously reported that EV exhibited osteopreserve effects in ovariectomized rats (Zhang et al. 2007) and mice (Zhang et al. 2010) and identified types of prenylated isoflavones with soy isoflavone genistein as the backbone from EV (Li et al. 2006). Among these prenylated genistein derivatives, using in vitro biological measurements, we revealed that 8-prenylgenistein (8PG) could increase the ability in stimulating osteoblastic function in comparison to genistein (Zhang et al. 2008). Additionally, the phytoestrogen-free diet supplemented with 8PG (300 ppm) protected against oestrogen deficiency-induced osteoporosis in mice and 8PG (300 & 600 ppm) did not produce the uterotrophic effect that was shown in genistein-treated ovariectomized mice (Zhang et al. 2018).