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Infections
Published in Charles Theisler, Adjuvant Medical Care, 2023
Echinacea: A study reported that the extract of Echinacea purpurea taken orally can kill many different kinds of bacteria, including Streptococcus pyogenes (S. pyogenes) which is responsible for strep throat, toxic shock syndrome, and the “flesh-eating dis-ease” known as necrotizing fasciitis.7
AI in Fighting against COVID-19
Published in Fadi Al-Turjman, AI-Powered IoT for COVID-19, 2020
Deepanshu Srivastava, S. Rakeshkumar, N. Gayathri, Fadi Al-Turjman
The herb Echinacea (Echinacea purpurea) is supportive of the immune system and has a direct anti-viral action against colds and viral bronchitis. Preparations that include both the roots and the flowering tops are the most effective at helping the body resist the viruses.
Investigating links between diet and health outcomes
Published in Geoffrey P. Webb, Nutrition, 2019
Yale and Liu (2004) reported the results of a RCTs of an extract of the herb Echinacea purpurea on the severity and duration of cold symptoms. Between 6 and 24 h after the onset of symptoms, 128 people were randomly assigned to receive either a placebo or a 100 mg extract of the herb 3 times per day. The subjects were recruited by responding to local newspaper adverts. The authors found no significant difference between control and Echinacea groups in either the severity or duration of the symptoms.
Protective Effect of Leaf Ethanolic Extract Etlingera hemisphaerica Blume Against Mercuric Chloride Toxicity in Blood of Mice
Published in Journal of Dietary Supplements, 2019
Aceng Ruyani, Rendi Zulni Eka Putri, Pauzi Jundara, Efri Gresinta, Irwandi Ansori, Agus Sundaryono
Imunos was used in this research as a positive control for LE3H treatment. The ingredients of Imunos are Echinacea purpurea, zinc picolinate, selenium, and ascorbic acid. Echinacea purpurea extract plays an important role in the protection against toxicity (Rezaie et al., 2013). Zinc picolinate is zinc complex with picolinic acid, which can be used to increase zinc absorption in humans (Barrie et al., 1987) for supporting optimal metabolism. Selenium is an essential micronutrient in mammals, but is also recognized as toxic in excess. It exerts its biological functions through selenoproteins. Most selenoproteins, whose functions are known, are involved in redox systems and signaling pathways (Kurokawa and Berry, 2013). The results of verification through phytochemical test showed that tannins, flavonoids, and terpenoids could be detected in Imunos (Table 2). From these facts, it can be stated that LE3H and Imunos have the same two compounds: flavonoids and tannins. Therefore, the protective effect of LE3H is derived from the antioxidant activity of flavonoids (Pietta, 2000) and iron chelation activity of tannins (Ghate et al., 2015). Previous experiments demonstrated the interaction between selenium and methylmercury and, according to the facts, selenium can be applied as chelation therapy for acute mercury poisoning (Watanabe, 2002).
MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2
Published in Xenobiotica, 2018
Charles Awortwe, Meike Kaehler, Bernd Rosenkranz, Ingolf Cascorbi, Henrike Bruckmueller
Globally, Echinacea spp. based products are ranked as the second most popular herbal products used primarily for the management of upper respiratory tract infections, influenza and common cold (Jawad et al., 2012; Mousa, 2017). Different formulations of such products are available at pharmacies in sub-Saharan Africa as over-the-counter medications. Approximately 80% of these formulations contain Echinacea purpurea (EP) as the main herbal ingredient (Barnes et al., 2005). The recently purported immune boosting and anticancer properties of EP have significantly contributed to the ready availability of EP in developing countries endemic with HIV/AIDS, TB and associated cancers (Hudson, 2012; Li et al., 2017; Tsai et al., 2012). Additionally, there is an increase aging population among HIV/AIDS and cancer patients on antiretroviral and cytostatic drugs, respectively due to prolonged life expectancy (Antiretroviral Therapy Cohort Collaboration, 2017; Howard et al., 2016; Katz & Maughan-Brown, 2017). The plausibility of co-usage of EP with conventional medications in such population is predictably high, which may cause pharmacokinetic and pharmacodynamic herb–drug interactions. Few herbal products are documented to cause pharmacokinetic and/or pharmacodynamic interactions with conventional medications and have been included in the black box warnings labels of victim drugs to serve as caution to patients (Clauson et al., 2008).
Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines
Published in Nutrition and Cancer, 2021
Daniel Abraham Espinosa-Paredes, Jorge Cornejo-Garrido, Mario Adán Moreno-Eutimio, Oswaldo Pablo Martínez-Rodríguez, María Eugenia Jaramillo-Flores, Cynthia Ordaz-Pichardo
The genus Echinacea belongs to the Asteraceae family, and it is mainly grown in the eastern regions of North America and in some regions of Europe. In traditional medicine, three species are the most frequently used: Echinacea purpurea, Echinacea pallida, and Echinacea angustifolia, where E. purpurea is the most commonly used species (7). The genus Echinacea displays different biological activities, such as antiviral, immunomodulatory, and anticancer activities, among others (5,8–10). Chemical studies of the genus Echinacea describe several metabolites, such as echinosides, caffeic acid, chlorogenic acid, and alkylamides as possibly being responsible for the biological activities (11).