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Tixocortol Pivalate
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Two years later, 9 more patients (7 women, 2 men) were reported from the same hospital, seen in 1984 and 1985. The responsible agent was TP nose spray in 5 and ear drops in 4 individuals. In each case, contact dermatitis was localized on the face, especially around the nose or ears. Patch tests with 15 other corticosteroids were always negative safe one reaction to dexamethasone acetate. Patch testing with hydrocortisone 25% pet. was negative in 11/11 patients tested and positive to 20% in alcohol in only one individual (75).
TiO2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of lonicera japonica thunb
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Jinhua Zhu, Danyang Zhou, Dandan Wu, Wei Liu, Xiuhua Liu
Chemicals, including neochlorogenic acid, chlorogenic acid, caffeic acid, rutin, luteoloside, lonicerin, hyperin, Isochlorogenic acid C and luteolin were purchased from Sichuan Veikeqi Biological technology Co., Ltd. (Chengdu, China). Nordihydroguaiaretic acid (NDGA), 3-aminopropyl-trimethoxysilane (APTMS), glutaraldehyde, linoleic acid (LA), and titanium dioxide nanoparticles were bought from Aladdin Biochemical Technology Co., Ltd. (Shanghai, China). Dexamethasone Acetate Injection was purchased from local drug store (Kaifeng, China). MCI GEL CHP20P high porous polymers were bought from Mitsubishi Chemical Co., Ltd. (Tokyo, Japan). Dimethyl sulfoxide (DMSO), methanol, ethanol, ethyl ether, and acetate and other chemicals were bought from Tianjin Deen Chemical Reagent Co., Ltd. (Tianjin, China). 5-LOX and endotoxin lipopolysaccharide (LPS) were purchased from Sigma-Aldrich Chemical (St. Louis, MO, USA). CCK-8 and NO kit were bought from Beyotime Biotechnology Co., Ltd. (Shanghai, China). The reagents used in the cell experiments were purchased from Zhengzhou Purcell Life Technology Co., Ltd. (Zhengzhou, China). The RAW264.7 mouse macrophage cell lines were purchased from Wuhan Prosser Life Technology Co., Ltd. (Wuhan, China).
Ocular Permeation and Sustained Anti-inflammatory Activity of Dexamethasone from Kaolin Nanodispersion Hydrogel System
Published in Current Eye Research, 2018
Arunima Pramanik, Rudra Narayan Sahoo, Ashirbad Nanda, Rajaram Mohapatra, Ranveer Singh, Subrata Mallick
The swelling of the transparent lining of conjunctiva is a sign irritation often related to allergies or due to viral or bacterial infection. Topical administration of corticosteroid is suggested in the management and control of some forms of conjunctivitis, episcleritis, keratitis, and anterior uveitis.3 Dexamethasone acetate is used as topical ocular corticoids4 for the treatment of both anterior and posterior segment of the eye. Ocular inflammation as well as the breakdown of the blood ocular barrier in proliferative vitreoretinopathy can be reduced by topical dexamethasone administration.5
Stanniocalcin-1 Reduced Intraocular Pressure in Two Models of Ocular Hypertension
Published in Current Eye Research, 2021
Gavin W. Roddy, Uttio Roy Chowdhury, Kjersten J. Monson, Michael P. Fautsch
All studies were approved by the Mayo Clinic (Rochester, MN) IACUC and adhered to ARVO guidelines. To develop the steroid-induced ocular hypertension model, IOP was measured in both eyes of wild-type C57BL/6J mice (n = 7, 6–8 months old) twice daily with an iCare rebound tonometer and averaged for 3 consecutive days to obtain baseline pressure as previously described.17 At this point, dexamethasone acetate suspension (200 μg in 20 μl volume) was injected weekly into the inferior conjunctival fornix of one eye in a slow release formulation (sodium chloride [0.667 g/100 mL], edetate disodium USP dehydrate [0.05 g/100 mL], sodium bisulfate [0.1 g/100 mL], and creatinine [0/5 g/100 mL], pH 7) as previously described.32 The fellow eye received a weekly injection with slow release formulation (vehicle) without the dexamethasone. IOP was obtained 48 and 72 hrs post-injection, averaged, and recorded as the weekly IOP. After a sustained and elevated IOP response was observed in the dexamethasone injected group (experimental weeks 1–3), mice were randomized into two groups and dexamethasone injections were continued weekly for the duration of the experiment: in Group 1, both eyes were treated once daily with topical PBS (5 µL, n = 8; experimental weeks 4–6, treatment weeks 1–3), and in Group 2, both eyes were treated once daily with topical STC-1 (Biovender, Asheville, NC, 5 µL; 0.5 µg/µL, n = 10; experimental weeks 4–6, treatment weeks 1–3). In the final phase of the experiment (experimental weeks 7–9, treatment weeks 4–6), dexamethasone-injected animals in Group 2 continued to receive topical STC-1 while treatment was halted in the vehicle-injected fellow eye for a medication wash-out period (Table 1). For statistical purposes, the final week of each condition was selected (i.e. weeks 3, 6, and 9) for analysis. To determine if a difference in IOP was present among groups at week 6 and 9, a Kruskal-Wallis test was performed. An unpaired t-test was used to directly compare the two groups. Values for all statistical tests were considered significant at P < .05.