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Neurobehavioral Syndromes in Patients with Cerebrovascular Pathology
Published in José León-Carrión, Margaret J. Giannini, Behavioral Neurology in the Elderly, 2001
María Dolores Jiménez, Eva Cuartero, Jorge Moreno
Another research line tries to find drugs whose hemorrheologic action can improve the cerebral blood flow (by reducing blood viscosity and increasing erythrocytic deformability), thus preventing the progression of the VaD. This approach includes drugs such as pentoxifylline, cyclandelate, and vinpocetine. However, results concerning the efficacy of these drugs have been inconsistent.
Predicting initiation of preventive migraine medications: exploratory study in a large U.S. medical claims database
Published in Current Medical Research and Opinion, 2020
Janet H. Ford, Krista Schroeder, Dawn C. Buse, Shivang Joshi, Steven Gelwicks, Shonda A. Foster, Sheena K. Aurora
Recommendations for preventive treatments for migraine based on the U.S., Canadian, and European evidence-based guidelines have been published and include both recommendations for PMMs and behavioral interventions8–11. The following pharmacologic agents have been recommended by the American Academy of Neurology/American Headache Society as PMMs based on evidence, and expert consensus: Established efficacy (Level A) for metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, topiramate, frovatriptan; probably effective (Level B) for nadolol, amitriptyline, venlafaxine, atenolol, naratriptan, zolmitriptan; possibly effective (Level C) for candesartan, lisinopril, clonidine, guanfacine, carbamazepine, nebivolol, pindolol; and inadequate or conflicting data to support or refute use for gabapentin, fluoxetine, fluvoxamine, protriptyline, acenocoumarol, warfarin, picotamide, bisoprolol, nicardipine, nifedipine, nimodipine, verapamil, acetazolamide, cyclandelate11. OnabotulinumtoxinA is approved by the U.S. Food and Drug Administration for the prevention of chronic migraine. As per Canadian Headache Society guidelines, 11 drugs received a “strong” recommendation for use (topiramate, propranolol, nadolol, metoprolol, amitriptyline, gabapentin, candesartan, Petasites [butterbur], riboflavin, coenzyme Q10, and magnesium citrate)10.