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Medicinal Plants of China Focusing on Tibet and Surrounding Regions
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Jiangqun Jin, Chunlin Long, Edward J. Kennelly
Chemical constituents: More than 70 compounds have been isolated and identified, including chlorogenic acid (Figure 2.9), and other phenylpropanoids: syringin, 1,3-dicaffeoylquinicacid, 3-caffeoylquinicacid, 1,5-dicaffeoyl-4-succinoylquinicacid, 1,4-dicaffeoylquinicacid; flavonoids: rutin (Figure 2.9) hispidulin, jaceosidin, luteolin, nepetin, apigenin; coumarins: coumarin, osthol, isopimpinellin, bergapten, xanthotoxol, alloisoimperatorin, oroselol; lignans: arctigenin-4-O-(6″-O-acetyl-β-D-glucoside), arctigenin-4-O-(2″-O-acetyl-β-D-glucoside), arctigenin-4-O-(3″-O-acetyl-β-D- glucoside), arctiin, and arctigenin (Chik et al., 2015); steroids: bufotalin, telocinobufagin, gamabufotalin (Zhang et al., 2011), daucosterol, β-sitosterol; sesquiterpenes: sausinlactoneA-(1S,3S,5S,6S,7S,11S)-3-hydroxyl-11; polysaccharides: glucose, galactose, xylose, rhamnose, arabinose, and galacturonic acid; and ceramides (Chik et al., 2015).
Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells
Published in Pharmaceutical Biology, 2021
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka
The antiproliferative and cytotoxic effect of bufadienolides is known, however available data concerning these activities are limited. Han et al. tested a few bufadienolides (hellebrigenin, hellebrigenol, arenobufagin, bufotalin, and bufalin) on human liver cancer cells (HepG2). The results indicated that these compounds have significant antiproliferative effects in a concentration range below 150 ng/mL (Han et al. 2016). These authors also studied arenobufagin and hellebrigenin on human glioblastoma cell line U-87 (Han et al. 2018). Dose-dependent cytotoxicity was observed in these cells at the compounds concentration of about 20 ng/mL. Furthermore, this effect was not observed in normal cells – mouse primary astrocytes. Another authors showed inhibitory effect of bufalin and cinobufagin on the proliferation of androgen dependent (LNCaP) and independent prostate cancer cell lines (DU145 and PC3) (Yeh et al. 2003).