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Constipation
Published in Charles Theisler, Adjuvant Medical Care, 2023
Stimulants: Stimulants including rhubarb, aloe, castor oil, bisacodyl (Ducodyl, Dulcolax, Correctol), and senna (Senokot, Fletcher’s Castoria, Ex-Lax regular strength pills) cause the intestines to contract.2 There is strong evidence that aloe juice (100–200 mg/day), which contains latex is a powerful laxative.4 Bisacodyl taken by mouth should produce a bowel movement within 6–12 hours. Senna is an FDA-approved over-the-counter (OTC) laxative. The herbal liquid laxative senna (5–15 mL once or twice a day) is commonly used to relieve constipation.5 Senna can be used with psyllium or the stool softener docusate (Colace, Dulco Ease) in adults, including the elderly, and is considered safe and effective in children.6 It is also effective for treating constipation in people who have undergone anorectal surgery.7
Bowel disorders
Published in Henry J. Woodford, Essential Geriatrics, 2022
Glycerin and bisacodyl suppositories are available. Bisacodyl has a local stimulatory effect on bowel contractions. The suppositories have an effect in around 10–15 minutes.12 Glycerin has an osmotic action, drawing water into the stools.
Common problems in pregnancy
Published in Anne Lee, Sally Inch, David Finnigan, Therapeutics in Pregnancy and Lactation, 2019
Laxatives should be given only after these approaches have failed.33 Bulk-forming agents, including bran, ispaghula and sterculia, should be tried first. Docusate sodium, which acts as a stimulant and a softening agent, and lactulose have been used in pregnancy with no evidence of adverse effects. These are useful second-line agents. Stimulant laxatives, such as bisacodyl and senna, are systemically absorbed and so best avoided in pregnancy.33 In theory, they may cause uterine contractions if used in the third trimester. If other treatments have been ineffective, senna may be used short term.
Long-term treatment with plecanatide was safe and tolerable in patients with irritable bowel syndrome with constipation
Published in Current Medical Research and Opinion, 2019
Charles F. Barish, Robert A. Crozier, Patrick H. Griffin
Eligible patients were assigned to plecanatide 6 mg administered once daily for up to 53 weeks, with baseline (day 1) defined as visit 1 of the open-label trial. At the time this study was started, it was not yet clear which dose(s) of plecanatide would ultimately be approved; therefore, the highest dose for potential approval (6 mg) was selected for this open-label study, which represents a dose twice the strength of the currently marketed product. Dose adjustments and/or treatment interruptions of study drug were not permitted in this study. Patients who did not have a bowel movement for at least 72 hours were allowed to use bisacodyl 5 mg (1–3 tablets in a single dose) supplied by the sponsor as rescue medication.
Management of Neurogenic Bowel Dysfunction in Adults after Spinal Cord Injury
Published in The Journal of Spinal Cord Medicine, 2021
Jeffery Johns, Klaus Krogh, Gianna M. Rodriguez, Janice Eng, Emily Haller, Malorie Heinen, Rafferty Laredo, Walter Longo, Wilda Montero-Colon, Catherine S. Wilson, Mark Korsten
A bisacodyl suppository is a contact irritant that enhances gastric motility, increases fecal water content, and reduces transit time in the large intestine.156 The 2 variants available for bisacodyl suppositories are hydrogenated vegetable oil based (e.g., Dulcolax) and PEG based (e.g., Magic Bullet).90 The bases act as vehicles for delivering bisacodyl, the active ingredient.