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Betamethasone Valerate
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
General aspects of corticosteroids used on the skin and mucous membranes are discussed in chapter 2.4. A practical guideline for diagnosing allergic reactions to corticosteroids is presented in ref. 5. Intradermal testing may detect cases of sensitization to betamethasone valerate not identified by patch testing with the corticosteroid 1% alc. (37).See also betamethasone (chapter 3.37), betamethasone sodium phosphate (chapter 3.39) and betamethasone dipropionate (chapter 3.38).
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment
Published in Expert Opinion on Drug Delivery, 2022
Chunhong Li, Xiu Zheng, Mei Hu, Ming Jia, Rongrong Jin, Yu Nie
Macrophage-derived EVs have been extensively used as drug carriers, as their surface membrane proteins can confer the intrinsic targeting ability of host cells [124]. For instance, our group encapsulated dexamethasone sodium phosphate into exosomes modified with folic acid–polyethylene glycol–cholesterol, giving rise to a biomimetic drug delivery system that prolonged the circulation of the drug, improved its targeting to inflamed joints, as well as preserved bone and cartilage in mice with collagen-induced arthritis [125]. We also encapsulated IL-10 pDNA and the chemotherapeutic drug betamethasone sodium phosphate into M2 macrophage-derived exosomes, which upregulated IL-10 while downregulating IL-1β and tumor necrosis factor-α, ultimately promoting macrophage polarization from the M1 to M2 phenotype [124]. Tacrolimus-loaded poly(lactic-co-glycolic acid) (PLGA) NPs coated with macrophage-derived microvesicles (T-MMP) have also proven to be an efficient biomimetic vehicle for RA targeting and treatment in vitro and in vivo (Figure 5a) [126]. Encapsulating tacrolimus in microvesicles significantly improved its sustained release, prolonged its circulation time, and increased its targeting of inflammatory joints (Figure 5b-c), significantly reducing joint swelling and bone erosion (Figure 5d).
Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report
Published in Acta Odontologica Scandinavica, 2018
Anna-Maija Matela, Jaana Hagström, Hellevi Ruokonen
The choice of the therapeutic option depends on the site and size of the lesion. In case of small lesions, surgical excision is an effective treatment and only one tongue recurrence has been reported. Some larger lesions on lips, buccal or labial mucosa have been treated successfully using primarily intralesional corticosteroid injections (ranging from two to seven times between 10 and 28 days). Topical corticosteroids as ointments have yielded variable results. Saliva rinses medication away from gingiva and customized trays may be useful to lengthen the time of contact between the ointment and the gingiva. Single case reports of improvements with local testosterone, pimecrolimus and betamethasone sodium phosphate as a mouth rinse have been described.
Ultrasound-guided injection acupotomy as a minimally invasive intervention therapy for cervical spondylotic radiculopathy: a randomized control trial
Published in Annals of Medicine, 2023
Jianfeng Pu, Wenping Cao, Yetin Chen, Yunwu Fan, Ye Cao
To avoid spinal cord or brainstem infarction caused by intravascular injection, non-granular steroids (such as dexamethasone injection) are recommended for use as the blocking solution [8, 24, 30]. However, some studies confirmed that granular steroid injections are curative effect better than non-granular steroids, but that there is no significant difference in the incidence of adverse reactions [31]. In 2012, study in Korea used triamcinolone acetonide for selective cervical nerve root block under fluoroscopy. This drug was considered to be more effective than non-granular Betamethasone Sodium Phosphate Injection, as it provided longer pain relief with no serious complications [32]. In 2016, a study showed that the satisfaction of the same patients regarding the effectiveness of lumbar epidural injections was significantly higher for triamcinolone acetonide compared to dexamethasone, with the interval between re-injections also being longer [33]. Ultrasound guidance allows blood vessels to be identified accurately, and the trajectory of the needle tip can be tracked in real time, avoiding intravascular injection. We also selected the granular steroid Compound Betamethason Injection during treatment, which guaranteed safety and improved efficacy. The improvement of the subjects’ symptoms was most obvious within one month after the end of the course of treatment. Compared with baseline, the VAS and NDI scores of the two groups significantly decreased between one months after completing treatment, whereas the total score of SF-36 significantly rose compared to baseline. This improvement continued until 6 months after the end of the course of treatment.