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Consumer Views on Health Issues Arising from Food Products
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Harita R. Desai, Murlidhar Meghwal
Aspartame: It comprises of amino acid phenyl alanine and has been widely utilized as an artificial sweetening agent in soft drink and sweet food industries. Toxicity studies of aspartame in rats have shown a rise in phenyl alanine levels in brain. The phenyl alanine levels in brain were raised when consumed with carbohydrates. Significant rise in brain tyrosine levels was observed by synergistic use of Aspartame leading to a reduction in brain tryptophan levels that caused aggressive behavior. Reduced brain tryptophan levels reduced the brain serotonin levels furthermore aggravating the hyperactivity [64].
Lifestyle and Its Relationship to Pain
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Aspartame has been noted to increase pain symptoms and even simulate fibromyalgia and total body pain. More than 20 years ago I gave a presentation at a pain conference that prompted an attendee to write me a few months later to say that 2 months after no diet soda, her fibromyalgia pain was gone. Aspartame has been shown to have an effect on NMDA receptors, and perhaps from this line of research will come a better understanding of a relationship to pain.25
THE ANALYSIS OF ANIMAL CARCINOGENICITY EXPERIMENTS
Published in Richard G. Cornell, Statistical Methods for Cancer Studies, 2020
Richard G. Cornell, Robert A. Wolfe, William J. Butler
The data of E-70 give no indication of an effect of aspartame on tumor incidence for either males or females. The P values calculated with the Fisher-Irwin exact test are 0.79 and 0.66 for males and females, respectively. For males the incidence rate for controls is higher than for experimental rats; the two incidence rates are essentially the same for females.
Association between Consumption of Artificial Sweeteners and Breast Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies
Published in Nutrition and Cancer, 2023
Xia Ye, Yeyuan Zhang, Yujing He, Mingyuan Sheng, Jianing Huang, Wenzhu Lou
Derived from the above mechanism, artificial sweeteners seem to reduce the incidence of BC, but our research results show that there is no relationship between artificial sweeteners and BC. Over the past few decades, a large number of human studies have been conducted to examine the effects of each artificial sweetener that the Food and Drug Administration (FDA) has approved on a variety of nonmalignant and primarily metabolic health parameters, including weight gain and glucose metabolism. Although differences in study designs and populations make direct comparison difficult, no artificial sweetener has been consistently linked to negative health consequences, and according to FDA inspection, all are considered safe for consumption (42). Although the carcinogenic risk of artificial sweeteners is still debatable, certain of its by-products, such as formaldehyde, a by-product of aspartame metabolism, are known carcinogens. Formaldehyde, which can result in DNA damage, chromosomal abnormalities, and mitotic mistakes (43, 44), is one biological mechanism that has currently been established to be acceptable through experiment research. Furthermore, it is generally known that individuals with BRCA2 mutations have a 69% chance of developing BC. Formaldehyde is a high-risk factor for triggering BC because it can break down the BRCA2 protein, which was initially a tumor suppressor protein, and impair DNA damage repair mechanisms (45).
Hepatic susceptibility to oxidative damage after repeated concomitant exposure to aspartame and aflatoxin B1 in rats
Published in Drug and Chemical Toxicology, 2022
Naieli Schiefelbein Souto, Micheli Dassi, Ana Cláudia Monteiro Braga, Érica Vanessa Furlan Rosa, Michele Rechia Fighera, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari, Ana Flávia Furian
Aspartame (ASP) is one of the most used artificial sweeteners in the world. It has a high sweetness potential, which is 180–200 times greater than sucrose. Besides, it is cheaper than sugar and is an attractive alternative for manufacturers (Figlewicz et al. 2009, Marinovich et al. 2013). In this sense, ASP is incorporated into around six thousand products, including soft drinks, frozen dessert, yogurt, chewable multivitamins, and breakfast cereals. It is also used in about 600 pharmaceutical products and is, therefore, consumed by millions of people worldwide (Butchko and Stargel 2001, Rencüzoğullari et al. 2004, Magnuson et al. 2007, Marinovich et al. 2013, Lee and Ryu 2017, Rushing and Selim 2019). Approximately 50% of the aspartame molecule is metabolized in phenylalanine, 40% in aspartic acid and 10% in methanol. Since its approval in 1965, studies have been demonstrating several toxic manifestations in different tissues and organs including liver, kidney and brain (Simintzi et al. 2007, Abhilash et al. 2011, Ashok and Sheeladevi 2015, Ashok et al. 2017).
Nutraceutical Potential of Diet Drinks: A Critical Review on Components, Health Effects, and Consumer Safety
Published in Journal of the American College of Nutrition, 2020
Shareen Banga, Vikas Kumar, Sheenam Suri, Manisha Kaushal, Rasane Prasad, Sawinder Kaur
The Food Safety and Standards Authority of India (FSSAI) has set the permissible limit up to 145 ppm of caffeine in noncarbonated water-based drinks. For aspartame and acesulfame potassium, artificial sweeteners, the permissible level is up to 700 and 300 ppm in carbonated beverages and up to 600 and 300 ppm in non-carbonated ones, respectively (136). In addition, drinks containing aspartame should be mandatorily labeled as “not recommended for children and phenylketonurics” (137). In case of fruit-based beverages, the FSSAI has made it mandatory to mention the herb (added in the beverage) on the label and “non-carbonated water-based beverages” may contain ingredients independently or in combination (138). The FSSAI report states that although it is not mandatory to set an upper limit of caffeine content according to the European Union, it becomes imperative to mention “high caffeine content” on the labels of drinks containing more than 145 mg/kg of caffeine (135).