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Phyto constituent-Centered Byproducts and Nanomedicines as Leishmanicidal Scavengers
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Sabya Sachi Das, P. R. P. Verma, Sandeep Kumar Singh
Bafghi et al. (2014) evaluated oleo gum resin of Ferula asafetida (asafetida) on mortality and morbidity L. majorin vitro. Results showed that asafetida reticent the development of parasites in all doses in immobile and logarithmic phases. The ELISA measurement proposed that the feasibility of parasites expressively reduced after 48 h (P < 0.05) and hence these selective oleo gum resins could be moreover used for the cure of leishmaniasis. Regueira-Neto et al. (2018) estimated the antiprotozoan and cytotoxic potentials of red propolis samples and also equated the results with the samples achieved for the extract of plant resins isolated from Dalbergiae castophyllum trees. The IC50 perceived against the parasitic growths could be utilized without elevating the fibroblast cell damage.
Ameliorating Insulin Signalling Pathway by Phytotherapy
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
The plant is a perennial herb growing up to 1.5 m, belonging to family Umbelliferae. It is also known as asafoetida, and has a pungent smell, lending it the trivial name of stinking gum. Morphologically, leaves contain spacious sheathing petioles. The height of the flowering stem is 2.5–3 m long and hallow. The pale greenish-yellow coloured flower is in large compound umbels. The shape of the fruits are oval, flatform, thin, reddish brown in colour and contains a milky juice. Generally, this plant is rich in resin, endogeneous gum, and volatile oil. The resin portion is a mixture of sinotannols ‘A’ and ‘B’, ferulic acid, ferulsinaic acid and umbelliferone, while volatile oil portion contains organosulfide compounds, such as 2-butyl-propenyl-disulfide, diallyl sulfide, diallyl disulfide and dimethyl trisulfide (Mahendra and Bisht 2012). Figure 15.12 shows a few chemical compounds contained on F. asafoetida.
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Asafetida was used for tumors of the abdomen, indurations of the liver and spleen, corns, calluses, as well as felons and whitlows of the fingers, and carcinomata of the gums.4 Reported to be anodyne, antispasmodic, aperient, aphrodisiac, carminative, diuretic, emmenagogue, expectorant, laxative, nervine, sedative, stimulant, stomachic, and vermifuge, asafetida is a folk remedy for amenorrhea, asthma, bronchitis, cholera, colic, convulsions, cramps, croup, epilepsy, gas, hemiplegia, hysteria, insanity, lungs, neurasthenia, pertussis, polyps, rinderpest, sarcomas, sluggish intestines, spasms, and splenitis.1732,33 “Herbal Highs”51 recommends 1/2 teaspoon in warm water as a tranquilizer. Malays take asafetida for abdominal trouble, broken bones, and rheumatism, Javanese for stomachache and worms.41 Asafetida is used as an enema for intestinal flatulence. Homeopathically used for gas, osteopathy, and stomach cramps.33
Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells
Published in Nutrition and Cancer, 2021
Anwar Al-Mutairi, Abdur Rahman, Muddanna S. Rao
Foods have been used as remedies for different disease, including cancer. Several foods with anticancer properties were found in many research studies to inhibit malignant cell migration, invasion and metastasis in vitro as well as in vivo. Of all foods that have anticancer properties Nigella sativa (N. sativa) and Ferula asafetida (F. asafetida) are the most commonly used remedies. These two plants are natural food ingredient widely used in the Arabian Gulf region. N. sativa seeds and its oil, and F. asafetida rhizome extract are used extensively in food as spices in all parts of the world and in the Gulf region. Main bioactive constituents that have anticancer properties in N. sativa and F. asafetida are Thymoquinone (TQ) and Ferulic Acid (FA) (Figure 1), respectively3,4. TQ suppressed the proliferation of, and induced apoptosis in several cancer cells such as pancreatic carcinoma, myeloblastic leukemia, ovarian carcinoma, osteosarcoma, and colorectal carcinoma; while it showed minimal toxic effects on normal cells5. In animal models, TQ inhibited the growth of xenografted PC3-human prostate cancer6 and LNM35 lung cancer cells in mice7. FA also inhibited proliferation and induced apoptosis in osteosarcoma cells and DMBA-induced cancers, such as breast and skin cancer8–12.
The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models
Published in Nutrition and Cancer, 2022
Hanieh Azani, Masoud Homayouni Tabrizi, Ali Neamati, Farzanehsadat Khadem, Niloufar Khatamian
The Ferula assa-foetida L. (FA) belongs to the Umbelliferae family and grows in the central area of Iran (4). The oleo-gum-resin (asafetida) that is obtained from its stem and roots incisions has long been used as the anti-pain, -whooping cough, -bronchitis, and -asthma compound in Iranian folk medicine (5). Moreover, there are various types of bioactivities have been recently reported for asafetida extract such as antioxidant (6), anti-inflammatory (7), and cancer chemo-preventive properties (8).