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Anti-Hyperglycemic Property Of Medicinal Plants
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Karanpreet Singh Bhatia, Arpita Roy, Navneeta Bhardavaj
Argyreia nervosa with a vernacular name Vidhara or Elephant creeper is a fellow of Convolvulaceae family and native to Indian Subcontinent and has spread to regions worldwide like Africa, Caribbean, and Hawaii. It has been used for its medicinal properties in Ayurvedic medicines. It has been reported that application of alcoholic extract of elephant creeper at a dosage of 250, 500, 750 mg/kg leads to amelioration in blood sugar in normal as well as AI hyperglycemic rats (HemaLatha et al., 2008). Ethanolic extract of A. nervosa roots (0.5 g/kg b.w.), when administrated orally, elicited a lowering effect on blood glucose levels in normoglycemic (at 6 hour) as well as in STZ-I hyperglycemic rats (after 7 days) (Kumar et al., 2010).
Hallucinogens, CNS Stimulants, And Cannabis
Published in S.J. Mulé, Henry Brill, Chemical and Biological Aspects of Drug Dependence, 2019
Yet, another morning glory relative, the Hawaiian Baby Woodrose, or Argyreia nervosa, has found extensive usage as a hallucinogenic plant source. Both ergine and isoergine have been shown to be present in exceptionally large amounts,9,10 but penniclavine (Figure 4), a minor component of both the Rivea and Ipomoea species, is also present as a major component. Again, its pharmacology in man is unknown. A recent study of this potent plant material11 revealed the presence of more than a dozen additional alkaloids, and it is certain that some of them must play some role in the explanation of the hallucinogenic effectiveness of this plant. The large Hawaiian Wood Rose (Ipomoea tuberosa) is interestingly without alkaloids and biological activity.
Protecting Pancreatic β-cells from Metabolic Insults
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Methanol extract of stems of Argyreia nervosa (Burm. f.) Bojer given orally to Sprague–Dawley rats at a single dose of 750 mg/kg reduced glycemia by 34.2% at 8 hours (Tolbutamide at 40 mg/kg: 29.6%).388 This extract given orally to alloxan-induced diabetic Sprague–Dawley rats (glycemia ≥250 mg/dL) at a single dose of 750 mg/kg reduced glycemia by 40.4% at 8 hours (Tolbutamide at 40 mg/kg: 35%).388 In oral glucose tolerance test in rats, the extract at 750 mg/kg lowered 30 minutes peak glycemia from 187.4 to 138.6 mg/dL.388 In alloxan-induced diabetic Sprague–Dawley rats, the extract at 750 mg/kg lowered 60 minutes peak glycemia from 387.5 to 176.8 mg/dL (Tolbutamide 40 mg/kg: 189.7 mg/dL).388,389 The plant, and especially the seeds, contain series of ergoline alkaloids such as d-lysergic acid amide and isoergine,390 which are hallucinogenic rendering the plant unfit for therapeutic purposes. These alkaloids are agonists of dopamine D2 receptors.391 Garcia-Tornadu et al. (2010) provided evidence that dopamine inhibits insulin secretion by β-cells via dopamine D2 receptors in mice.392
Argyreia nervosa (Samudra pala) leaf extract mediated silver nanoparticles and evaluation of their antioxidant, antibacterial activity, in vitro anticancer and apoptotic studies in KB oral cancer cell lines
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Gunashekar Kalvakunta Subramanyam, Susmila Aparna Gaddam, Venkata Subbaiah Kotakadi, Sashikiran Palithya, Josthna Penchalaneni, Varadarajulu Naidu Challagundla
In the present study, we have selected one such plant namely “Argyreia nervosa” which was reported to have several medicinal properties and is widely used in Ayurveda. A. nervosa attracted the attention of several researchers worldwide for its pharmacological activities. A. nervosa is mostly spread throughout India, belongs to the family Convolvulaceae is a climbing shrub with a woody tomentose stem. It is commonly known as Elephant Creeper and Samudrapala in Telugu and Samudra-sok in Hindi [19]. The various plant parts of A. nervosa prove to have a broad spectrum of activity on quite a large number of ailments A. nervosa plant parts are reported to contain flavonoids, sterol glycoside, flavonoids, and essential oil which are responsible for several pharmacological properties [20,21].
Argyreia nervosa exposures reported to Texas poison centers
Published in Journal of Addictive Diseases, 2018
Argyreia nervosa, commonly known as Hawaiian baby woodrose, elephant creeper, elephant vine, silver morning glory, and wooly morning glory, is a member of the morning glory family (Convolvulaceae). Native to India, Argyreia nervosa is now found in other countries in the tropics and subtropics, spread as a result of its use as an ornamental, medicinal, and hallucinogenic plant.1–3Argyreia nervosa is a perennial liana or climbing vine with a woody stem, large, heart-shaped leaves 18–27 cm in length, and white trumpet-shaped flowers. It produces 4–4.5 cm brown-black seeds.1–3