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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
In pharmaceutical preparations, lactic acid is also employed as sodium lactate (CAS number 72-17-3, EC number 200-772-0, molecular formula C3H5NaO3) and as ammonium lactate (CAS number 515-98-0, EC number 208-214-8, molecular formula C3H9NO3).
Lymphoedema – investigation and treatment
Published in Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland, Manual of Venous and Lymphatic Diseases, 2017
Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland
Simple moisturisers such as glycerine prevent skin cracking and dramatically reduce infection risk as they increase the barrier to the external environment. Topical emollients and keratolytics stabilize skin; ammonium lactate 5% lotion decreases scaling and pruritus, while topical urea preparations promote hydration and remove excess keratin.
Infantile Atopic Dermatitis
Published in Donald Rudikoff, Steven R. Cohen, Noah Scheinfeld, Atopic Dermatitis and Eczematous Disorders, 2014
Sadaf H. Hussain, James R. Treat, Albert C. Yan
Topical soybean trypsin inhibitors also function as inhibitors of skin serine proteases and their future use in emollients may provide a novel approach to improving skin barrier repair (Isogai et al. 2002). Their role in managing infantile atopic dermatitis remains to be determined. Certain emollients, however, should be avoided in infants. Keratolytic moisturizers containing salicylic acid, ammonium lactate, or urea should be used with caution in infants with impaired skin barriers. Not only do they cause stinging and burning, but also systemic absorption of the active ingredients is possible, especially in the context of abnormal skin integrity and increased surface area:weight ratios (Mancini 2004).
Dupilumab use in dermatologic conditions beyond atopic dermatitis – a systematic review
Published in Journal of Dermatological Treatment, 2021
Aleksi J. Hendricks, Gil Yosipovitch, Vivian Y. Shi
Chronic hand eczema (CHE) is a common and debilitating condition with significant diagnostic and management challenges. Clinical manifestations are highly variable, but involve intensely pruritic and painful areas of erythema, edema and fissuring, causing a significant negative impact on patients’ activity level and quality of life (30). It is a heterogenous diagnosis encompassing several etiologies, including allergic and irritant contact dermatitis (often occupational or household exposures) and atopic hand dermatitis, with morphologic classifications including dyshidrotic (vesicular) and hyperkeratotic hand dermatitis (31). Treatment approaches for CHE include allergen or irritant avoidance along with topical corticosteroids, calcineurin inhibitors and janus kinase inhibitors, as well as systemic therapies including retinoids and traditional immunosuppressive agents (32). Treatment for the hyperkeratotic subtype involves topical keratolytics such as urea, ammonium lactate and salicylic acid, and systemic retinoids including acitretin and alitretinoin (32).
Poroid hidradenoma of the scalp in a US Veteran’s Administration (VA) patient
Published in Case Reports in Plastic Surgery and Hand Surgery, 2021
M. Mukit, M. Mitchell, I. Ortanca, N. Krassilnik, X. Jing
A fifty-eight-year-old male with a history of hypertension, anxiety, depression, and chronic low back pain presented with a one-year history of a right parietal scalp mass. He believed that the mass first appeared after he bumped his head, but he was not sure. The patient denied any drainage, pain, numbness, tingling, fever, or redness. Medications included acetaminophen, bacitracin, ranitidine, ketotifen fumarate, ammonium lactate, castellani colorless topical paint, urea 20% cream, celecoxib, and cyclobenzaprine. The patient denied any smoking, alcohol, or drug use. Family history was non-contributory, and he had no known drug allergies. On physical exam, he was found to have a mobile and cystic appearing right parietal scalp mass with a punctum. The differential diagnosis included an epidermal inclusion cyst, pilar cyst, or lipoma.
Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review
Published in Journal of Dermatological Treatment, 2023
Nicole Natarelli, Amanda Krenitsky, Kerry Hennessy, Sarah Moore, James Grichnik
The search strategy yielded five studies or reports performed in 1990–2020 that included a treatment group(s) that did not correspond with the above categories. Klaus et al. assessed the effect of 12% ammonium lactate (Lac-Hydrin) on lesion characteristics(n = 58) (29). After BID application for sixteen weeks, a significant reduction in SK elevation was observed, with no difference in width or number. The unchanging size and minimal texture/color improvement suggest Lac-Hydrin is ineffective compared to first-line treatments and other topicals in the treatment of SKs.